The extra-curricular activities in the program of a high school

Thesis (Ed.M.)--Boston Universit

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer

The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an immunohistochemistry-based assessment of combined CD3+ and CD8+ T-cell density (the “Immunoscore”), in conjunction with assessment of the tumor stroma percentage (TSP) in patients undergoing resection of stage I-III colorectal cancer (CRC). 246 patients were identified from a prospectively maintained database of CRC resections in a single surgical unit. Assessment of KM grade and TSP was performed using full H&E sections. CD3+ and CD8+ T-cell density was assessed on full sections and the Immunoscore calculated. KM grade and Immunoscore were strongly associated (P<0.001). KM grade stratified cancer-specific survival (CSS) from 88% to 66% (P=0.002) and Immunoscore from 93% to 61% (P<0.001). Immunoscore further stratified survival of patients independent of KM grade from 94% (high KM, Im4) to 60% (low KM, Im0/1). Furthermore, TSP stratified survival of patients with a weak inflammatory cell infiltrate (low KM: from 75% to 47%; Im0/1: from 71% to 38%, both P<0.001) but not those with a strong inflammatory infiltrate. On multivariate analysis, only Immunoscore (HR 0.44, P<0.001) and TSP (HR 2.04, P<0.001) were independently associated with CSS. These results suggest that the prognostic value of an immunohistochemistry-based assessment of the inflammatory cell infiltrate is superior to H&E-based assessment in patients undergoing resection of stage I-III CRC. Furthermore, assessment of the tumor-associated stroma, using TSP, further improves prediction of outcome

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding

Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer reviewedPostprin

Counterterrorism Killings and Provisional IRA Bombings, 1970-1998

Counterterrorism strategies involving the killing of terrorists are a prominently used but controversial practice. Proponents argue that such strategies are useful tools for reducing terrorist activity, while critics question their effectiveness. This paper provides empirical insight into this strategy by conducting a series of negative binomial regression and Tobit estimations of the impact of killing Provisional Irish Republican Army (PIRA) terrorists as well as members of the Catholic community on counts of PIRA bombings and targeting activity in Northern Ireland for the period 1970-1998. We consider the impact of discriminate and indiscriminate killings (where only PIRA militants are killed versus those in which both militants and civilians are also killed) on subsequent PIRA IED attacks. Our findings illustrate that while total and discriminate counterterrorism killings have little to no effect on PIRA IED attacks, indiscriminate counterterrorism killings increased PIRA bombings overall and prompted the Provisional IRA to specifically target civilians in IED events. We conclude by discussing the scholarly and policy implications of these findings

Foreshadowing targeted violence: Assessing leakage of intent by public mass murderers

The idea that identifiable behaviors presage violence is a core concept in the threat assessment literature. Especially meaningful from an operational perspective is “leakage”, which concerns whether offenders intentionally or unintentionally reveal insights into their thoughts or feelings that suggest impending targeted violence. Previous research has generally been limited to assessing the prevalence of leakage in various offender populations. The present study more thoroughly describes leakage in a sample of 115 public mass murderers in the U.S. whose activities took place between 1990 and 2014. We disaggregate leakage into three distinct forms (written statements, verbal statements to the public, verbal statements to family/friends), and examine these in relation to theorized correlates of leakage. The only significant predictor of leakage we found is the presence of a grievance, specifically a grievance against a person or entity, as opposed to a grievance against a category of people or a grievance against an idea, movement or religion. We discuss implications of these results as well as directions for future research

S_3 and the L=1 Baryons in the Quark Model and the Chiral Quark Model

The S_3 symmetry corresponding to permuting the positions of the quarks within a baryon allows us to study the 70-plet of L=1 baryons without an explicit choice for the spatial part of the quark wave functions: given a set of operators with definite transformation properties under the spin-flavor group SU(3) x SU(2) and under this S_3, the masses of the baryons can be expressed in terms of a small number of unknown parameters which are fit to the observed L=1 baryon mass spectrum. This approach is applied to study both the quark model and chiral constituent quark model. The latter theory leads to a set of mass perturbations which more satisfactorily fits the observed L=1 baryon mass spectrum (though we can say nothing, within our approach, about the physical reasonableness of the parameters in the fit). Predictions for the mixing angles and the unobserved baryon masses are given for both models as well as a discussion of specific baryons.Comment: 24 pages, requires picte