Stability of continuously pumped atom lasers

A multimode model of a continuously pumped atom laser is shown to be unstable below a critical value of the scattering length. Above the critical scattering length, the atom laser reaches a steady state, the stability of which increases with pumping. Below this limit the laser does not reach a steady state. This instability results from the competition between gain and loss for the excited states of the lasing mode. It will determine a fundamental limit for the linewidth of an atom laser beam.Comment: 4 page

Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon

Current models of the virus-like agents of scrapie and bovine spongiform encephalopathy (BSE) have to take into account that structural changes in a host-encoded protein (PrP protein) exhibit an effect on the time course of these diseases and the survival time of any man or animal exposed to these pathogens. We report here the sequence of different forms of the bovine PrP gene which contain either five or six copies of a short, G-C-rich element which encodes the octapeptide Pro-His-Gly-Gly-Gly-Trp-Gly-Gln or its longer variants Pro-Gln/His-Gly-Gly-Gly-Gly-Trp-Gly-Gln. Out of 12 cattle, we found eight animals homozygous for genes with six copies of the Gly-rich peptide (6:6), while four were heterozygous (6:5). Two confirmed cases of BSE occurred in (6: 6) homozygous animals. Bovine spongiform encephalopathy (BSE) is a transmissible disease (Fraser et al., 1988; Dawson et al., 1990; Barlow & Middleton, 1990) which produces neuropathological lesions in cattle similar to those seen in ovine scrapie (Wells et al., 1987) and the rare human dementias Creutzfeldt-Jakob disease (CJD) and Gerstmann-Str/iussler syndrome (GSS) (Beck & Daniel, 1987). A cellular membrane protein (PrP) has a key role in the transmission and development of these diseases. This protein accumulates in the brain and other tissues during the protracted time course of these diseases and, in a disease-specific, protease-resistant isoform (SAF-PrP), has been purified by subcellular fractionation of scrapie

Multimode quantum limits to the linewidth of an atom laser

The linewidth of an atom laser can be limited by excitation of higher energy modes in the source Bose-Einstein condensate, energy shifts in that condensate due to the atomic interactions, or phase diffusion of the lasing mode due to those interactions. The first two are effects that can be described with a semiclassical model, and have been studied in detail for both pumped and unpumped atom lasers. The third is a purely quantum statistical effect, and has been studied only in zero dimensional models. We examine an unpumped atom laser in one dimension using a quantum field theory using stochastic methods based on the truncated Wigner approach. This allows spatial and statistical effects to be examined simultaneously, and the linewidth limit for unpumped atom lasers is quantified in various limits.Comment: 8 Figure

Pulsed pumping of a Bose-Einstein condensate

In this work, we examine a system for coherent transfer of atoms into a Bose-Einstein condensate. We utilize two spatially separate Bose-Einstein condensates in different hyperfine ground states held in the same dc magnetic trap. By means of a pulsed transfer of atoms, we are able to show a clear resonance in the timing of the transfer, both in temperature and number, from which we draw conclusions about the underlying physical process. The results are discussed in the context of the recently demonstrated pumped atom laser.Comment: 5 pages, 5 figures, published in Physical Review

Quantum kinetic theory model of a continuous atom laser

We investigate the feasible limits for realising a continuously evaporated atom laser with high-temperature sources. A plausible scheme for realising a truly continuous atom laser is to outcouple atoms from a partially condensed Bose gas, whilst continuously reloading the system with non-condensed thermal atoms and performing evaporative cooling. Here we use quantum kinetic theory to model this system and estimate feasible limits for the operation of such a scheme. For sufficiently high temperatures, the figure of merit for the source is shown to be the phase-space flux. The dominant process limiting the usage of sources with low phase-space flux is the three-body loss of the condensed gas. We conclude that certain double-magneto-optical trap (MOT) sources may produce substantial mean condensate numbers through continuous evaporation, and provide an atom laser source with a narrow linewidth and reasonable flux.Comment: 28 pages, 5 figure

Achieving peak brightness in an atom laser

In this paper we present experimental results and theory on the first continuous (long pulse) Raman atom laser. The brightness that can be achieved with this system is three orders of magnitude greater than has been previously demonstrated in any other continuously outcoupled atom laser. In addition, the energy linewidth of a continuous atom laser can be made arbitrarily narrow compared to the mean field energy of a trapped condensate. We analyze the flux and brightness of the atom laser with an analytic model that shows excellent agreement with experiment with no adjustable parameters.Comment: 4 pages, 4 black and white figures, submitted to Physical Revie

Modelling the hepatitis B vaccination programme in prisons

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. Over the coming years it is anticipated this vaccination programme will be extended. A model has been developed to assess the potential impact of the programme on the vaccination coverage of prisoners, ex-prisoners, and injecting drug users (IDUs). Under a range of coverage scenarios, the model predicts the change over time in the vaccination status of new entrants to prison, current prisoners and IDUs in the community. The model predicts that at baseline in 2012 57% of the IDU population will be vaccinated with up to 72% being vaccinated depending on the vaccination scenario implemented. These results are sensitive to the size of the IDU population in England and Wales and the average time served by an IDU during each prison visit. IDUs that do not receive HBV vaccine in the community are at increased risk from HBV infection. The HBV vaccination programme in prisons is an effective way of vaccinating this hard-to-reach population although vaccination coverage on prison reception must be increased to achieve this

Classical noise and flux: the limits of multi-state atom lasers

By direct comparison between experiment and theory, we show how the classical noise on a multi-state atom laser beam increases with increasing flux. The trade off between classical noise and flux is an important consideration in precision interferometric measurement. We use periodic 10 microsecond radio-frequency pulses to couple atoms out of an F=2 87Rb Bose-Einstein condensate. The resulting atom laser beam has suprising structure which is explained using three dimensional simulations of the five state Gross-Pitaevskii equations.Comment: 4 pages, 3 figure

Exploratory study of clinician and patient views regarding the use of a preconception care app for women with diabetes

Background: Women with diabetes are at increased risk of adverse maternal and fetal outcomes. Preconception care can minimise risk of complications and improve outcomes, but current provision is inadequate. Electronic health technology, particularly apps, could improve preconception care provision but research is lacking in this area. Aim: The aim of this paper is to explore the views and experiences of clinicians and women with diabetes regarding the use of a mobile app for preconception care. Method: An exploratory study was conducted. Data were collected using focus group and interviews with 19 participants, comprising 10 clinicians and 9 women with type 1 or 2 diabetes. Data were analysed thematically. Findings: Women with diabetes and clinicians highlighted the inadequacy and challenges of current preconception care service provision and expressed a high level of enthusiasm and interest, towards a preconception care app that could support preconception care delivery for women with diabetes and overcome barriers to preconception care service provision and uptake. Conclusion: The acceptability of mobile health technology to both women and clinicians creates an important opportunity to overcome existing barriers to service provision, delivery and uptake, and improve both maternal and fetal outcomes for women with diabetes