Two photon annihilation of Kaluza-Klein dark matter

We investigate the fermionic one-loop cross section for the two photon annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray line with energy equal to the KK dark matter particle mass. We find that the cross section is large enough that if a continuum signature is detected, the energy distribution of gamma-rays should end at the particle mass with a peak that is visible for an energy resolution of the detector at the percent level. This would give an unmistakable signature of a dark matter origin of the gamma-rays, and a unique determination of the dark matter particle mass, which in the case studied should be around 800 GeV. Unlike the situation for supersymmetric models where the two-gamma peak may or may not be visible depending on parameters, this feature seems to be quite robust in UED models, and should be similar in other models where annihilation into fermions is not helicity suppressed. The observability of the signal still depends on largely unknown astrophysical parameters related to the structure of the dark matter halo. If the dark matter near the galactic center is adiabatically contracted by the central star cluster, or if the dark matter halo has substructure surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio

Surface plasmon polaritons on narrow-ridged short-pitch metal gratings

Ian R. Hooper and J. Roy Sambles, Physical Review B, Vol. 66, article 205408 (2002). "Copyright © 2002 by the American Physical Society."The reflectivity of short pitch metal gratings consisting of a series of narrow Gaussian ridges in the classical mount has been modeled as a function of frequency and in-plane wave vector (the plane of incidence containing the grating vector) for various ridge heights. Surface plasmon polaritons (SPP’s) are found to be excited even in the zero-order region of the spectrum. These may result in strong absorption of radiation polarized with its electric field in the plane of incidence (transverse magnetic). For zero in-plane wave vector the SPP modes consist of a symmetric charge distribution on either side of the grating ridges, a family of these modes existing with different numbers of field maxima per grating period. Because of the charge symmetry these modes may only be coupled to at angles away from normal incidence where strong resonant absorption may then occur. The dispersion of these SPP modes as a function of the in-plane wave vector is found to be complex arising from the formation of very large band gaps due to the harmonic content of the grating profile, the creation of a pseudo high-energy mode, and through strong interactions between different SPP bands

Helminth Infection, Fecundity, and Age of First Pregnancy in Women

Infection with intestinal helminths results in immunological changes that influence the odds of comorbid infections, and might also affect fecundity by inducing immunological states supportive of conception and pregnancy. Here we investigate associations between intestinal helminths and fertility in human females, utilizing nine years of longitudinal data from 986 Bolivian forger-horticulturalists, experiencing natural fertility and a 70% helminth prevalence. We find that different species of helminth are associated with opposing effects on fecundity. Infection with roundworm (Ascaris lumbricoides) is associated with earlier first births and shortened interbirth intervals, while infection with hookworm is associated with delayed first pregnancy and extended interbirth intervals. Thus, helminths may have important, and sometimes contradictory effects on human fertility, reflecting the physiological and immunological consequences of infection with particular species

Assessment of a self-reported Drinks Diary for the estimation of drinks intake by care home residents: Fluid Intake Study in the Elderly (FISE)

Objectives: We evaluated the accuracy of a newly developed self-completed Drinks Diary in care home residents and compared it with direct observation and fluid intake charts. Design: Observational study. Setting: Residential care homes in Norfolk, UK. Participants: 22 elderly people (18 women, mean age 86.6 years SD 8.6, 12 with MMSE scores <27). Measurements: Participants recorded their own drinks intake over 24 hours using the Drinks Diary while care staff used the homes’ usual fluid intake chart to record drinks intake. These records were compared with drinks intake assessed by researcher direct observation (reference method), during waking hours (6am to 10pm), while drinks taken from 10pm to 6am were self-reported and checked with staff. Results: Drinks intake assessed by the Drinks Diary was highly correlated with researcher direct observation (Pearson correlation coefficient r=0.93, p<0.001, mean difference -163ml/day) while few staff-completed fluid charts were returned and correlation was low (r=0.122, p=0.818, mean difference 702ml/day). The Drinks Diary classified 19 of 22 participants correctly as drinking enough or not using both the European Food Safety Authority and US recommendations. Conclusion: The Drinks Diary estimate of drinks intake was comparable with direct observation and more accurate (and reliably completed) than staff records. The Drinks Diary can provide a reliable estimate of drinks intake in elderly care home residents physically and cognitively able to complete it. It may be useful for researchers, care staff and practitioners needing to monitor drinks intake of elderly people, to help them avoid dehydration

Determining Supersymmetric Parameters With Dark Matter Experiments

In this article, we explore the ability of direct and indirect dark matter experiments to not only detect neutralino dark matter, but to constrain and measure the parameters of supersymmetry. In particular, we explore the relationship between the phenomenological quantities relevant to dark matter experiments, such as the neutralino annihilation and elastic scattering cross sections, and the underlying characteristics of the supersymmetric model, such as the values of mu (and the composition of the lightest neutralino), m_A and tan beta. We explore a broad range of supersymmetric models and then focus on a smaller set of benchmark models. We find that by combining astrophysical observations with collider measurements, mu can often be constrained far more tightly than it can be from LHC data alone. In models in the A-funnel region of parameter space, we find that dark matter experiments can potentially determine m_A to roughly +/-100 GeV, even when heavy neutral MSSM Higgs bosons (A, H_1) cannot be observed at the LHC. The information provided by astrophysical experiments is often highly complementary to the information most easily ascertained at colliders.Comment: 46 pages, 76 figure

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.

BACKGROUND: Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studies have established that splicing of both the K-ras oncogene and proto-oncogene is altered in CRC in favour of K-ras 4B. The present study addressed whether the K-Ras 4A proto-oncoprotein can suppress tumour development in the absence of its oncogenic allele, utilising the ApcMin/+ (Min) mouse that spontaneously develops intestinal tumours that do not harbour K-ras activating mutations, and the K-rastmDelta4A/tmDelta4A mouse that can express the K-ras 4B splice variant only. By this means tumorigenesis in the small intestine was compared between ApcMin/+, K-ras+/+ and ApcMin/+, K-rastmDelta4A/tmDelta4A mice that can, and cannot, express the K-ras 4A proto-oncoprotein respectively. METHODS: The relative levels of expression of the K-ras splice variants in normal small intestine and small intestinal tumours were quantified by real-time RT-qPCR analysis. Inbred (C57BL/6) ApcMin/+, K-ras+/+ and ApcMin/+, K-rastmDelta4A/tmDelta4A mice were generated and the genotypes confirmed by PCR analysis. Survival of stocks was compared by the Mantel-Haenszel test, and tumour number and area compared by Student's t-test in outwardly healthy mice at approximately 106 and 152 days of age. DNA sequencing of codons 12, 13 and 61 was performed to confirm the intestinal tumours did not harbour a K-ras activating mutation. RESULTS: The K-ras 4A transcript accounted for about 50% of K-ras expressed in the small intestine of both wild-type and Min mice. Tumours in the small intestine of Min mice showed increased levels of K-ras 4B transcript expression, but no appreciable change in K-ras 4A transcript levels. No K-ras activating mutations were detected in 27 intestinal tumours derived from Min and compound mutant Min mice. K-Ras 4A deficiency did not affect mouse survival, or tumour number, size or histopathology. CONCLUSION: The K-Ras 4A proto-oncoprotein does not exhibit tumour suppressor activity in the small intestine, even though the K-ras 4A/4B ratio is reduced in adenomas lacking K-ras activating mutations.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

The Particle Physics Reach of High-Energy Neutrino Astronomy

We discuss the prospects for high-energy neutrino astronomy to study particle physics in the energy regime comparable to and beyond that obtainable at the current and planned colliders. We describe the various signatures of high-energy cosmic neutrinos expected in both neutrino telescopes and air shower experiments and discuss these measurements within the context of theoretical models with a quantum gravity or string scale near a TeV, supersymmetry and scenarios with interactions induced by electroweak instantons. We attempt to access the particle physics reach of these experiments.Comment: Mini-review article for New Journal of Physics, "Focus on Neutrinos" issue. 27 pages, 11 figure

Direct versus indirect detection in mSUGRA with self-consistent halo models

We perform a detailed analysis of the detection prospects of neutralino dark matter in the mSUGRA framework. We focus on models with a thermal relic density, estimated with high accuracy using the DarkSUSY package, in the range favored by current precision cosmological measurements. Direct and indirect detection rates are computed implementing two models for the dark matter halo, tracing opposite regimes for the phase of baryon infall, with fully consistent density profiles and velocity distribution functions. This has allowed, for the first time, a fully consistent comparison between direct and indirect detection prospects. We discuss all relevant regimes in the mSUGRA parameter space, underlining relevant effects, and providing the basis for extending the discussion to alternative frameworks. In general, we find that direct detection and searches for antideuterons in the cosmic rays seems to be the most promising ways to search for neutralinos in these scenarios.Comment: 26 pages, 9 figure

Axino dark matter from thermal production

The axino is a promising candidate for dark matter in the Universe. It is electrically and color neutral, very weakly interacting, and could be - as assumed in this study - the lightest supersymmetric particle, which is stable for unbroken R-parity. In supersymmetric extensions of the standard model, in which the strong CP problem is solved via the Peccei-Quinn mechanism, the axino arises naturally as the fermionic superpartner of the axion. We compute the thermal production rate of axinos in supersymmetric QCD. Using hard thermal loop resummation, we obtain a finite result in a gauge-invariant way, which takes into account Debye screening in the hot quark-gluon-squark-gluino plasma. The relic axino abundance from thermal scatterings after inflation is evaluated. We find that thermally produced axinos could provide the dominant part of cold dark matter, for example, for an axino mass of 100 keV and a reheating temperature of 10^6 GeV.Comment: 33 pages, 7 figures, 1 table, erratum adde