Prevalence of Metabolic Syndrome according to Sasang Constitutional Medicine in Korean Subjects

Metabolic syndrome (MS) is a complex disorder defined by a cluster of abdominal obesity, atherogenic dyslipidemia, hyperglycemia, and hypertension; the condition is recognized as a risk factor for diabetes and cardiovascular disease. This study assessed the effects of the Sasang constitution group (SCG) on the risk of MS in Korean subjects. We have analyzed 1,617 outpatients of Korean oriental medicine hospitals who were classified into three SCGs, So-Yang, So-Eum, and Tae-Eum. Significant differences were noted in the prevalence of MS and the frequencies of all MS risk factors among the three SCGs. The odds ratios for MS as determined via multiple logistic regression analysis were 2.004 for So-Yang and 4.521 for Tae-Eum compared with So-Eum. These results indicate that SCG may function as a significant risk factor of MS; comprehensive knowledge of Sasang constitutional medicine may prove helpful in predicting susceptibility and developing preventive care techniques for MS

Association of the Apolipoprotein A5 Gene −1131T>C Polymorphism with Serum Lipids in Korean Subjects: Impact of Sasang Constitution

Apolipoprotein A5 (APOA5) was identified as a strong modulator of serum lipids. Moreover, an APOA5 gene −1131T>C polymorphism has been associated with serum lipids, but the results are inconsistent according to ethnic and racial groups. We have genotyped and analyzed 1,619 outpatients of Korean oriental medicine hospitals who were classified into three Sasang constitution groups (SCGs), So-Yang (SY), So-Eum (SE), and Tae-Eum (TE). There were no significant difference in the distribution of the APOA5 −1131T>C genotype among the three SCGs. Subjects with the C allele in SY and TE showed significantly lower serum high-density lipoprotein cholesterol (HDL-C) and higher triglyceride (TG) levels than noncarriers of the C allele. These results show the differences in the prevalence of decreasing serum HDL-C and elevating serum TG levels along with APOA5 −1131T>C polymorphism according to SCG and suggest that SCG may act as a significant risk factor for hypo-HDL-C-emia and hypertriglyceridemia susceptibility

Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation

T cells navigate diverse microenvironments to perform immune responses. Micro-scale topographical structures within the tissues, which may inherently exist in normal tissues or may be formed by inflammation or injury, can influence T cell migration, but how T cell migration is affected by such topographical structures have not been investigated. In this study, we fabricated ramp-like structures with a 5 mu m height and various slopes, and observed T cells climbing up the ramp-like structures. T cells encountering the ramp-like structures exhibited MLC accumulation near head-tail junctions contacting the ramp-like structures, and made turns to the direction perpendicular to the ramp-like structures. Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (MLCK) were responsible for the intriguing turning behavior of T cells climbing the ramp-like structures. Arp2/3 or MLCK inhibition substantially reduced probability of T cells climbing sharp-edged ramp-like structures, indicating intriguing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be important for T cells to access inflamed or injured tissues with abrupt topographical changes.11Ysciescopu

Ultra Wide Range Tunable Delay Line Using Dynamic Grating Reflectors in Optical Fibers

We experimentally demonstrate a novel technique to realize a tunable delay line based on dynamic Brillouin gratings in a high birefringence fiber. A 8ns pulse signal is continuously delayed up to 184ns with minor distortion

Progress in Brillouin Slow Light and Its Impact in Fiber Sensing

This paper reviews the major advances in Brillouin slow light devices along the last two years. We also focus on the positive and negative implications of this effect in the development of fiber sensors

La lumière lente et rapide: une future pièce maîtresse pour la photonique

Nous présentons une technique permettant de réaliser un contrôle extensif et très souple de la vitesse de groupe de signaux se propageant dans une fibre optique. Ce contrôle, directement piloté par une source lumineuse, est effectué par le truchement de gains ou de pertes générés dans la fibre par diffusion Brillouin stimulée. Nos résultats montrent que des vitesses de groupe inférieures à 71'000 km/s d’une part, dépassant la vitesse de la lumière dans le vide d’autre part, et même des vitesses négatives, ont pu être obtenues à l’aide d’un simple montage tenant sur une table optique

Flexible Slow and Fast Light Using Tailored Brillouin Spectra in Optical Fibers

Stimulated Brillouin scattering makes possible the generation of synthesized gain spectra, so that innovative slow light schemes can be realized, ranging from broadband tunable delays to a zero-gain situation identical to an ideal electromagnetically-induced transparency

Prognostic factors for aorta remodeling after thoracic endovascular aortic repair of complicated chronic DeBakey IIIb aneurysms

ObjectivesThe use of thoracic endovascular aortic repair (TEVAR) for chronic DeBakey III type b (CDIIIb) aneurysms is controversial. We analyzed the potential prognostic factors affecting aorta remodeling after this procedure.MethodsA total of 20 patients with CDIIIb aneurysms underwent TEVAR, with full coverage of reentry tears at the descending thoracic aorta. The potential factors affecting false lumen (FL) remodeling were analyzed, including reentry tears (communicating channels visible on the computed tomography angiogram), large intimal tears below the stent graft (≥2 consecutive axial cuts on the computed tomography angiogram), visceral branches arising from the FL, and intercostal arteries (ICAs) arising from the FL.ResultsAll the patients had uneventful in-hospital courses; 2 patients (10%) required reintervention during the follow-up period. Thirteen patients (65%) had complete thrombosis of the FL at stent graft segment. Compared with the complete thrombosis group, the partial thrombosis group had more reentry tears (1.8 vs 2.3, P = .48), large intimal tears (0.8 vs 1.7, P < .05), visceral branches arising from the FL (1.2 vs 2.3, P < .05), and ICAs arising from the FL (3.8 vs 5.1, P = .35). Reentry tears, visceral branches, and ICAs from the FL were significant negative prognostic factors for FL shrinkage (P < .05).ConclusionsAlthough reentry tears above the celiac trunk were fully covered, the visceral branches and ICAs from the FL and all communicating channels below the celiac trunk kept the FL pressurized and were unfavorable prognostic factors for aorta remodeling after TEVAR for CDIIIb aneurysms

Light Controlling Light in an Optical Fibre: From Very Slow to Faster-Than-Light Speed

We demonstrate a method to achieve an extremely wide and flexible external control of the group velocity of signals as they propagate along an optical fibre. This control is achieved by means of the gain and loss mechanisms of stimulated Brillouin scattering in the fibre itself. Our experiments show that group velocities below 71,000 km/s on one hand, well exceeding the speed of light in vacuum on the other hand and even negative group velocities can readily be obtained with a simple benchtop experimental setup. Advanced schemes can be realized thanks to the extremely flexible possibility to shape the gain spectrum to make it optimized for applications. Ultra wide bandwidth, delaying with flat amplitude response and lower distortion were successfully demonstrated this way