EFFECT OF DIFFERENT TRACK START POSITiONS ON HORIZONTAL TAKE-OFF VELOCITY OF WHOLE-SODY CENTER OF MASS IN SWIMMING: A SlMUALTION STUDY

The objective of this study was to investigate the effects of different track start positions on horizontal take-off velocity of the whole-body center of mass (COM) in swimming. The whole body was modeled as linked rigid-body segments to simulate the track start performance, and a simulation was performce with two different track start positions, with the COM positioned at the rear and low level (RL), and at the front and high level (FH). The results demonstrated that the horizontal take-off velocity was faster for the RL than the FH. The hip joint moments were larger for the RL than the FH on both front and rear legs. Therefore, the COM positioned at the rear and lower level for the track start would contribute to a greater hip joint moment generation, producing a greater horizontal velocity of the COM at take-off

Infection risk in hemodialysis patient

Chronic care patients undergoing hemodialysis for treatment of end-stage renal failure experience higher rates of bloodstream-associated infection due to the patients' compromised immune system and management of the bloodstream through catheters. Staphylococcus species are a common cause of hemodialysis catheter-related bloodstream infections. We investigated environmental bacterial contamination of dialysis wards and contamination of hemodialysis devices to determine the source of bacteria for these infections. All bacterial samples were collected by the swab method and the agarose stamp method. And which bacterium were identified by BBL CRYSTAL Kit or 16s rRNA sequences. In our data, bacterial cell number of hemodialysis device was lower than environment of patient surrounds. But Staphylococcus spp. were found predominantly on the hemodialysis device (46.8%), especially on areas frequently touched by healthcare-workers (such as Touch screen). Among Staphylococcus spp., Staphylococcus epidermidis was most frequently observed (42.1% of Staphylococcus spp.), and more surprising, 48.2% of the Staphylococcus spp. indicated high resistance for methicillin. Our finding suggests that hemodialysis device highly contaminated with bloodstream infection associated bacteria. This study can be used as a source to assess the risk of contamination-related infection and to develop the cleaning system for the better prevention for bloodstream infections in patients with hemodialysis

Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma

Current clinically approved biomarkers for the PD-1 blockade cancer immunotherapy are based entirely on the properties of tumour cells. With increasing awareness of clinical responses, more precise biomarkers for the efficacy are required based on immune properties. In particular, expression levels of immune checkpoint-associated molecules such as PD-1, PD-L1, and CTLA-4 would be critical to evaluate the immune state of individuals. Although quantification of their soluble form leased from the membrane will provide quick evaluation of patients’ immune status, available methods such as enzyme-linked immunosorbent assays to measure these soluble factors have limitations in sensitivity and reproducibility for clinical use. To overcome these problems, we developed a rapid and sensitive immunoassay system based on chemiluminescent magnetic technology. The system is fully automated, providing high reproducibility. Application of this system to plasma of patients with several types of tumours demonstrated that soluble PD-1, PD-L1, and CTLA-4 levels were increased compared to those of healthy controls and varied among tumour types. The sensitivity and detection range were sufficient for evaluating plasma concentrations before and after the surgical ablation of cancers. Therefore, our newly developed system shows potential for accurate detection of soluble PD-1, PD-L1, and CTLA-4 levels in the clinical practice

Experimental transmission of quantum digital signatures over 90-km of installed optical fiber using a differential phase shift quantum key distribution system

Quantum digital signatures apply quantum mechanics to the problem of guaranteeing message integrity and non-repudiation with information-theoretical security, which are complementary to the confidentiality realized by quantum key distribution. Previous experimental demonstrations have been limited to transmission distances of less than 5-km of optical fiber in a laboratory setting. Here we report the first demonstration of quantum digital signatures over installed optical fiber as well as the longest transmission link reported to date. This demonstration used a 90-km long differential phase shift quantum key distribution system to achieve approximately one signed bit per second - an increase in the signature generation rate of several orders of magnitude over previous optical fiber demonstrations