Distribution of Propranolol in Periocular Tissues: A Comparison of Topical and Systemic Administration

Purpose: Oral propranolol has become a promising treatment of capillary hemangiomas (CHs) despite concerns of side effects associated with systemic beta-blockers. The objective of this study was to investigate the distribution of propranolol in periocular tissues and in plasma after topical application of propranolol as compared with intravenous and oral administration of propranolol. Methods: Each rabbit received propranolol as ophthalmic solution (1%) in one eye (1.5 mg dose), intravenous injection (1.5 mg dose), or commercially available propranolol oral solution (5 mg dose). The periocular tissues (e.g., eyelids and extraocular muscles) and blood were collected and assayed for propranolol. Results:After topical instillation of 1.5 mg propranolol, high amounts of propranolol were rapidly delivered to the eyelids and extraocular muscles (4−32 μg/g at 1 h after dosing). The drug in these tissues was slowly cleared, and significant amounts of the drug (\u3e0.4 μg/g) were still present at 24 h after the topical application. After oral administration of a clinically relevant dose of 5 mg propranolol, the drug concentrations in the periocular tissues were relatively low ( Conclusions: Topical administration can provide increased concentrations of propranolol in the periocular tissues and, thus, is superior to systemic administration for the treatment of periocular CH

Investigation on the effects of Bragg reflection on harbor oscillations

Periodic undulating topographies (such as sandwaves and sandbars) are very common in coastal and estuarine areas. Normally incident water surface waves propagating from open sea to coastal areas may interact strongly with such topographies. The wave reflection by the periodic undulating topography can be significantly amplified when the surface wavelength is approximately twice the wavelength of the bottom undulations, which is often called as Bragg resonant reflection. Although the investigations on the hydrodynamic characteristics related to Bragg reflection of a region of undulating topography have been widely implemented, the effects of Bragg reflection on harbors have not yet been studied. Bragg resonant reflection can effectively reduce the incident waves. Meanwhile, however, it can also significantly hinder the wave radiation from the harbor entrance to the open sea. Whether Bragg reflection can be utilized as a potential measure to alleviate harbor oscillations is unknown. In the present study, Bragg reflection and their interactions with the harbor are simulated using a fully nonlinear Boussinesq model, FUNWAVE 2.0. For the purpose, an elongated harbor with constant depth is considered, and a series of sinusoidal bars with various amplitudes and numbers are deployed outside the harbor. The incident waves considered in this paper include regular long waves and bichromatic short wave groups. It is revealed for the first time that for both kinds of incident waves, Bragg resonant reflection can significantly alleviate harbor resonance. The influences of the number and the amplitude of sinusoidal bars on the mitigation effect of harbor resonance and on the optimal wavelength of sinusoidal bars that can achieve the best mitigation effect are comprehensively investigated, and it is found that the former two factors have remarkable influences on the latter two parameters. The present research provides a new option for the mitigation of harbor oscillations via changing the bottom profile, which is feasible as long as the navigating depth is guaranteed.</p

Prevalence of hyperglycemia among adults with newly diagnosed HIV/AIDS in China

BACKGROUND: The prevalence of hyperglycemia among HIV-infected persons who are not receiving antiretroviral therapy is unknown. We conducted a cross-sectional survey to estimate the prevalence of hyperglycemia among Chinese adults with newly diagnosed HIV/AIDS. METHODS: Two thousand and six newly diagnosed HIV/AIDS patients from 10 provinces and municipalities in China were selected during 2009 to 2010. After an overnight fast, serum samples were collected to measure glucose concentrations. Demographics and medical histories were recorded. Factors associated with the presence of diabetes were analysed by logistic regression. RESULTS: Among the 2006 patients, 75.67% were male. Median age was 40 years (range: 18–86 years). 19.99% had hyperglycemia, 9.47% had impaired fasting glucose (IFG) and 10.52% had diabetes. The prevalences of hyperglycemia, of IFG and of diabetes were 21.54%, 10.28% and 11.27% among men and 15.16%, 6.97% and 8.20% among women, respectively. The prevalence of diabetes increased with increasing age (7.00%, 13.36% and 21.21% among patients who were 18–40, 40–60, and ≥60 years of age respectively) and with decreasing CD4 count (6.74%, 8.45%, 9.69%, and 12.66% among patients with CD4 count of ≥350, 200–350, 50–200, and < 50/mm(3) respectively). The prevalence of diabetes was higher among ethnic minority patients than among the Han patients (14.37% versus 9.24%). The logistic analysis showed that older age, lower CD4 count and minority ethnicity were significantly associated with an increased risk of diabetes. CONCLUSIONS: Hyperglycemia is highly prevalent among Chinese adults with newly diagnosed HIV/AIDS. Older age, lower CD4 count and minority ethnicity are associated with increased risk of diabetes. All newly diagnosed HIV/AIDS individuals should be routinely evaluated for hyperglycemia

The Novel Monkeypox Outbreak: What Should We Know and Reflect On?

While the COVID-19 pandemic continues, the world is on high alert regarding the second public health threat of a global monkeypox outbreak. Monkeypox, a relative of smallpox, is a zoonotic disease that was initially restricted to Africa. However, a novel outbreak has occurred in Europe, a non-endemic region, starting in May 2022. In the face of this unprecedented event, people should be aware of several crucial facts regarding monkeypox to support global public health prevention and control of the outbreak, including pathogenetic epidemiological and diagnostic aspects. As the cases outside Africa rapidly increase, including in a large proportion of men who have sex with men, thinking about the potential effects on global public health, as well as the shifting epidemiological trends of monkeypox and the insights from this novel outbreak, will be crucial

Interferon-Gamma Release Assays for the Diagnosis of Active Tuberculosis in HIV-Infected Patients: A Systematic Review and Meta-Analysis

BACKGROUND: Interferon-gamma release assays (IGRAs) have provided a new method for the diagnosis of Mycobacterium tuberculosis infection. However, the role of IGRAs for the diagnosis of active tuberculosis (TB), especially in HIV-infected patients remains unclear. METHODS: We searched PubMed, EMBASE and Cochrane databases to identify studies published in January 2001-July 2011 that evaluated the evidence of using QuantiFERON-TB Gold in-tube (QFT-GIT) and T-SPOT.TB (T-SPOT) on blood for the diagnosis of active TB in HIV-infected patients. RESULTS: The search identified 16 eligible studies that included 2801 HIV-infected individuals (637 culture confirmed TB cases). The pooled sensitivity for the diagnosis of active TB was 76.7% (95%CI, 71.6-80.5%) and 77.4% (95%CI, 71.4-82.6%) for QFT-GIT and T-SPOT, respectively, while the specificity was 76.1% (95%CI, 74.0-78.0%) and 63.1% (95%CI, 57.6-68.3%) after excluding the indeterminate results. Studies conducted in low/middle income countries showed slightly lower sensitivity and specificity when compared to that in high-income countries. The proportion of indeterminate results was as high as 10% (95%CI, 8.8-11.3%) and 13.2% (95%CI, 10.6-16.0%) for QFT-GIT and T-SPOT, respectively. CONCLUSION: IGRAs in their current formulations have limited accuracy in diagnosing active TB in HIV-infected patients, and should not be used alone to rule out or rule in active TB cases in HIV-infected patients. Further modification is needed to improve their accuracy

Reliability Evaluation of NC Machine Tools considering Working Conditions

Reliability evaluation is the basis for reliability design of NC machine tools. Since traditional reliability evaluation methods do not consider the working conditions&apos; effects on reliability, there is a great error of a result of a traditional method compared with an actual value. A new reliability evaluation model of NC machine tools is proposed based on the Cox proportional hazards model, which describes the mathematical relation between the working condition covariates and the reliability level of NC machine tools. Firstly, the coefficients of working condition covariates in the new reliability evaluation model are estimated by the partial likelihood estimation method; secondly, the working condition covariates which have no effects on the reliability of NC machine tools are eliminated by the likelihood ratio test; then parameters of the baseline failure rate function are estimated by the maximum likelihood estimation method. Thus, the reliability evaluation model of NC machine tool is obtained under different working conditions and the reliability level of NC machine tools is obtained. Case study shows that the proposed method could establish the relation between the working condition covariates and the reliability level of NC machine tools, and it would provide a new way for the reliability evaluation of NC machine tools

Technology Development Through Pooling ARV Drug Patents: A Vision from China

Unaffordable prices still bar the end-users in China from accessing ARV drugs. Patent protection of ARV drugs has dramatically limited the availability of these lifesaving drugs to AIDS patients in China

Analysis of Milling Quality of Reasonably Well Milled Rice with Three Different Grain Shapes

In order to explore changes in the milling quality of reasonably well milled rice with different grain shapes, the bran degree, milling degree and broken rice rate of short-grained (‘Jihong 6’), medium-grained (‘Daohuaxiang’) and long-grained (‘Yexiangyoulisi’, ‘Yexiang’ for short) brown rice were measured after milling at different temperatures and for different periods. The results showed that the bran degree decreased exponentially with an increase in milling pressure for ‘Jihong 6’ and ‘Daohuaxiang’ and an increase in milling time for ‘Yexiang’. For reasonably well milled rice with bran degree from 7.0% to 2.0%, as specified by China’s national standard GB/T 1354–2018, the percentage change in milling degree of ‘Jihong 6’, ‘Daohuaxiang’ and ‘Yexiang’ were approximately 5.03%, 2.98% and 0.18%, respectively, indicating that the milling degree of reasonably well milled rice did not change more significantly with increasing grain length. The broken rice rates of ‘Daohuaxiang’, ‘Jihong 6’ and ‘Yexiang’ increased by 5.32, 0.25 and 0.21 percentage points, respectively, and the white rice yields decreased by 1.38, 2.74 and 0.21 percentage points, respectively. The change in broken rice rate of ‘Yexiang’ for reasonably well milled rice was the smallest. The broken rice rates of ‘Daohuaxiang’, ‘Jihong 6’ and ‘Yexiang’ at bran degree of 0.10% increased by 10.36–4.77, 1.85–1.60, and 10.05–9.84 percentage points, respectively compared with those at bran degree from 7.0% to 2.0%, and the white rice yields decreased by 4.19–2.81, 7.02–4.28 and 10.65–10.44 percentage points, respectively. So, the effect of changes in broken rice rate at bran degree of 0.10% on white rice yield was more pronounced. ‘Daohuaxiang’ with bran degree of 2.10%–2.45% met germ retention rate of less than 20% for high-quality japonica rice specified in the national standard, while ‘Jihong 6’ and ‘Yexiang’ with bran degree from 7.0% to 2.0% did not meet this requirement. At bran degree from 7.0% to 2.0%, the whiteness of ‘Daohuaxiang’, ‘Jihong 6’ and ‘Yexiang’ increased by 6.65, 2.80 and 2.69 percentage points, respectively. There was no significant regular change in the breaking strength of the three rice varieties. The bran degree had a significant correlation with the degree of milling, whiteness and germ retention rate in reasonably well milled rice. As observed by scanning electron microscopy (SEM), the difference in thickness between the dorsal and ventral regions of ‘Yexiang’ was the smallest. When the bran degree was about 2.00%, the ventral aleurone layer of the three types of rice was almost entirely removed, while much of the aleurone layer was remained in the dorsal part. When the bran degree was about 0.10%, a small amount of the dorsal aleurone layer was retained for ‘Daohuaxiang’ and ‘Jihong 6’, while the dorsal aleurone layer of ‘Yexiang’ was completely removed. Therefore, the milling degree required for uniform whitening of brown rice and the processing quality vary with cultivar and grain shape

Carbon Dioxide and Water Electrolysis Using New Alkaline Stable Anion Membranes

The recent development and market introduction of a new type of alkaline stable imidazole-based anion exchange membrane and related ionomers by Dioxide Materials is enabling the advancement of new and improved electrochemical processes which can operate at commercially viable operating voltages, current efficiencies, and current densities. These processes include the electrochemical conversion of CO2 to formic acid (HCOOH), CO2 to carbon monoxide (CO), and alkaline water electrolysis, generating hydrogen at high current densities at low voltages without the need for any precious metal electrocatalysts. The first process is the direct electrochemical generation of pure formic acid in a three-compartment cell configuration using the alkaline stable anion exchange membrane and a cation exchange membrane. The cell operates at a current density of 140 mA/cm2 at a cell voltage of 3.5 V. The power consumption for production of formic acid (FA) is about 4.3–4.7 kWh/kg of FA. The second process is the electrochemical conversion of CO2 to CO, a key focus product in the generation of renewable fuels and chemicals. The CO2 cell consists of a two-compartment design utilizing the alkaline stable anion exchange membrane to separate the anode and cathode compartments. A nanoparticle IrO2 catalyst on a GDE structure is used as the anode and a GDE utilizing a nanoparticle Ag/imidazolium-based ionomer catalyst combination is used as a cathode. The CO2 cell has been operated at current densities of 200 to 600 mA/cm2 at voltages of 3.0 to 3.2 respectively with CO2 to CO conversion selectivities of 95–99%. The third process is an alkaline water electrolysis cell process, where the alkaline stable anion exchange membrane allows stable cell operation in 1 M KOH electrolyte solutions at current densities of 1 A/cm2 at about 1.90 V. The cell has demonstrated operation for thousands of hours, showing a voltage increase in time of only 5 μV/h. The alkaline electrolysis technology does not require any precious metal catalysts as compared to polymer electrolyte membrane (PEM) design water electrolyzers. In this paper, we discuss the detailed technical aspects of these three technologies utilizing this unique anion exchange membrane