Experimental study on discretely modulated continuous-variable quantum key distribution

We present a discretely modulated continuous-variable quantum key distribution system in free space by using strong coherent states. The amplitude noise in the laser source is suppressed to the shot-noise limit by using a mode cleaner combined with a frequency shift technique. Also, it is proven that the phase noise in the source has no impact on the final secret key rate. In order to increase the encoding rate, we use broadband homodyne detectors and the no-switching protocol. In a realistic model, we establish a secret key rate of 46.8 kbits/s against collective attacks at an encoding rate of 10 MHz for a 90% channel loss when the modulation variance is optimal.Comment: 7 pages,6 figure

Original Article Effects of angiotensin-converting enzyme inhibition and bradykinin peptides in rats with myocardial infarction

Abstract: Background and objective: Angiotensin-converting enzyme (ACE) inhibitors have been reported to decrease myocardial remodeling and faciliate cardiac function improvement in the setting myocardial infarction by affecting bradykinin. The purpose of this study was to evaluate the combination effects of perindopril and bradykinin (BK) in rats with myocardial infarction. Methods: Wistar Rats underwent to left anterior descending (LAD) coronary artery ligation were allocated into MI group (n = 6); Perindopril group (n = 7); Perindopril + BK group (n = 7). An additional sham operation group (Sham group, n = 6) were also established. After 4 weeks, the left ventricle function, myocardial tissue morphology, myocardial collagen volume faction, infracted ventricular wall thickness, myocardial infarction area and neovascular formation were evaluated. Results: Combination treatment with perindopril and BK were showed significant improvement on LVEDV, LVEF and LVFS than MI group. Moreover, a significant improvement on LVEF was found in Perindopril + BK group than Perindopril group but not on LVEDV and LVFS between these two groups. Furthermore, neo-vessel density was significantly increased in Perindopril + BK group than other groups while no significant improvement on vessel density was found after the treatment of perindopril. In addition, myocardial infarction thickness improvement was found in Perindopril and group than MI group while combination treatment with perindopril and BK can significant improve the myocardial infarction thickness than perindopril only. Conclusions: Combination treatment with ACE inhibitor perindopril and BK can significantly improve the ventricle function in the rat model of myocardial infarction. Our data suggest BK can serve as adjuvant treatment in myocardial infarction treatment

Research on the niche evolution game of ecological community innovation of corporate venture capital based on logistic extended complexity model

With the gestation and development of new technologies, new products, new formats, and new models, venture capital in- vestment, as one of the most important forms of open innovation in large companies, plays an increasingly important role in the innovation of mature large companies and entrepreneurial enterprises. To deal with the complex and dynamic environment, the niche of Corporate Venture Capital (CVC) ecological community is investigated from the perspective of the innovation eco- system. By analyzing the innovation of CVC ecological community with the use of the logistic expansion model, this paper analyzes the stability of evolution game through the replicator dynamic equation and discusses ten parameters of niche state. In the end, we conclude that there are four optimization strategies in the coevolution of major corporations and entrepreneurial rms, namely, niche separation, niche expansion, niche K-R, and niche alliance

Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery

Background: Blood–brain barrier (BBB) is a crucial but dynamic structure that functions as a gatekeeper for the central nervous system (CNS). Managing sufficient substances across the BBB is a major challenge, especially in the development of therapeutics for CNS disorders. Methods: To achieve an efficient, fast and safe strategy for BBB opening, an acoustofluidic transwell (AFT) was developed for reversible disruption of the BBB. The proposed AFT was consisted of a transwell insert where the BBB model was established, and a surface acoustic wave (SAW) transducer realized using open-source electronics based on printed circuit board techniques. Results: In the AFT device, the SAW produced acousto-mechanical stimulations to the BBB model resulting in decreased transendothelial electrical resistance in a dose dependent manner, indicating the disruption of the BBB. Moreover, SAW stimulation enhanced transendothelial permeability to sodium fluorescein and FITC-dextran with various molecular weight in the AFT device. Further study indicated BBB opening was mainly attributed to the apparent stretching of intercellular spaces. An in vivo study using a zebrafish model demonstrated SAW exposure promoted penetration of sodium fluorescein to the CNS. Conclusions: In summary, AFT effectively disrupts the BBB under the SAW stimulation, which is promising as a new drug delivery methodology for neurodegenerative diseases. Graphical Abstract

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

A DEA-model evaluation of the efficiency of peasant household credit investigation system in rural credit cooperatives: A positive research in Hubei Province, China

Purpose – As a major agricultural province in central China, Hubei Province mainly carries out the peasant household credit investigation system through rural credit cooperatives (RCCs). The purpose of this paper is to evaluate the efficiency of the peasant household credit investigation system in Hubei RCCs and provide some evidence and ideas to the formulation of relevant policies. Design/methodology/approach – First, this paper briefly reviews the related literature of the efficiency in credit investigation system; second, the paper gives a brief description of the data envelopment analysis (DEA) model and designs the indicators for efficiency evaluation; third, the paper accounts data sources and processing methods; and finally, the paper performs the empirical analysis and draws a conclusion. Findings – The paper finds that the efficiency of the resource allocation in both regions is unoptimistic, the general efficiency is somewhat low, and it shows the trend of declination. The efficiency of pure technology in two regions represents the adverse trend. Every year's average scale efficiency in both regions is higher than the pure technology efficiency. Originality/value – The main contributions of this paper include the first use of DEA model to practically evaluate the efficiency of credit investigation system based on 54 samples of RCCs in Hubei Province and the horizontal and vertical comparisons of the results. The conclusions of this paper not only make the efficiency of credit investigation system in the province's 54 credit cooperatives comparable but also has a great application value to the actual decision-making departments in formulating credit policies, and each credit cooperative in further building the credit investigation system according to its own conditions. Moreover, it has certain reference value to other similar studies.China, Co-operative organizations, Credit, Loans, Rural economics

Computational analysis of spray cooling heat transfer and Influential factors during glass tempering

The spray cooling and tempering technology has a series of advantages, such as improving the tempering quality and reducing energy consumption. In order to optimize the tempering technological parameters, it is necessary to accurately control the thermal history and temperature distribution of a hot glass surface during spray cooling. However, measuring the inner temperature of tempered glass proved challenging. The Euler-Lagrangian approach was utilized for simulating the process of spray cooling the glass surface. To validate the accuracy of model predictions, experimental studies were conducted on the tempering of glass by a single nozzle. The numerical outcomes exhibit strong correspondence with the experimental findings. Building upon the foundation, the study analyzed the heat transfer mechanisms in different states including film boiling, nucleate boiling, and forced convection. Subsequently, the effects of spray distance, spray loading fraction, spray pressure, and final cooling temperature on the heat transfer rate and temperature homogeneity were discussed. The results revealed that reducing the spray distance, increasing the spray loading fraction and spray pressure can improve the cooling rate and reduce energy consumption, but it aggravated the uneven distribution of temperature over the glass surface. Moderately increasing the final cooling temperature had little effect on the tempering quality of glass, but it significantly reduced the energy consumption for spray cooling. Within the experimental range, the optimal final cooling temperature was 573.15 K

Atorvastatin Improves Microenvironment to Enhance the Beneficial Effects of BMSCs Therapy in a Rabbit Model of Acute Myocardial Infarction

Background/Aims: To investigate the beneficial effects of atorvastatin added to the cell therapy with bone marrow-derived mesenchymal stromal cells (BMSCs) in a rabbit model of acute myocardial infarction (AMI). Methods: Rabbits were randomly divided into control group (n=10), bone marrow stem cells transplantation group (n=10), and BMSCs + atorvastatin group (n=10). AMI was established by ligating the left descending coronary artery. The left ventricular (LV) function was evaluated by echocardiography. H&#38;E staining and Masson's Trichrome staining were performed to evaluate inflammatory cell infiltration and cardiac fibrosis. Immunohistochemistry and TUNEL were conducted to assess survival, differentiation, and apoptosis of transplanted cells and cardiomyocytes. Results: BMSCs decreased LV systolic and diastolic diameters and increased LV ejection fractions, LV fractional shortening, LV systolic pressure and LV end-diastolic pressure. Atorvastatin synergistically enhanced the BMSCs-induced improvements of ischemic cardiac dysfunction. Atorvastatin reduced inflammatory cell infiltration, cardiac fibrosis, and derangement of myocardial morphology/structure. Atorvastatin added a protective effect to cardiomyocytes against apoptotic cell death in infarct and peri-infarct areas, and also increased the survival rate of implanted BMSCs in acute myocardial ischemia. Atorvastatin also promoted cardiac differentiation of implanted BMSCs in infarct myocardium. Conclusion: Atorvastatin acts to improve the microenvironment both by synergistically enhancing the existing effects of BMSCs and by adding new therapeutic effects to BMSCs transplantation, and this combinational therapy is a superior cell/pharmacological therapeutic approach that merits future preclinical and clinical studies