Impact of Assimilating Advanced Himawari Imager Channel 16 Data on Precipitation Prediction over the Haihe River Basin

Assimilation of high-resolution geostationary satellite data is of great value for precise precipitation prediction in regional basins. The operational geostationary satellite imager carried by the Himawari-8 satellite, Advanced Himawari Imager (AHI), has two additional water vapor channels and four other channels compared with its predecessor, MTSAT-2. However, due to the uncertainty in surface parameters, AHI surface-sensitive channels are usually not assimilated over land, except for the three water vapor channels. Previous research showed that the brightness temperature of AHI channel 16 is much more sensitive to the lower-tropospheric temperature than to surface emissivity, which is similar to the three water vapor channels 8–10. As a follow-up work, this paper evaluates the effectiveness of assimilating brightness temperature observations over land from both the three AHI water vapor channels and channel 16 to improve watershed precipitation forecasting through both case analysis (in the Haihe River basin, China) and batch tests. It is found that assimilating AHI channel 16 can improve the upstream near-surface atmospheric temperature forecast, which in turn affects the development of downstream weather systems. The precipitation forecasting test results indicate that adding the terrestrial observations of channel 16 to the assimilation of AHI data can improve short-term precipitation forecasting in the basin

DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism

Abstract Peripheral CD8+ T cell number is tightly controlled but the precise molecular mechanism regulating this process is still not fully understood. In this study, we found that epilepsy patients with loss of function mutation of DEPDC5 had reduced peripheral CD8+ T cells, and DEPDC5 expression positively correlated with tumor-infiltrating CD8+ T cells as well as overall cancer patient survival, indicating that DEPDC5 may control peripheral CD8+ T cell homeostasis. Significantly, mice with T cell-specific Depdc5 deletion also had reduced peripheral CD8+ T cells and impaired anti-tumor immunity. Mechanistically, Depdc5-deficient CD8+ T cells produced high levels of xanthine oxidase and lipid ROS due to hyper-mTORC1-induced expression of ATF4, leading to spontaneous ferroptosis. Together, our study links DEPDC5-mediated mTORC1 signaling with CD8+ T cell protection from ferroptosis, thereby revealing a novel strategy for enhancing anti-tumor immunity via suppression of ferroptosis