Research on Task Scenario-oriented Information User Concern Mining Technology

With the rapid evolution of war forms and the profound reform of combat forms, battlefield intelligence information will present complex and diverse characteristics. Faced with a large number of complex intelligence information, it is difficult for users to obtain the key information in the battlefield to make real-time decision aid by using traditional methods. Based on the analysis of user interaction behavior rules of intelligence users of different levels, different identities and different specialties facing different task scenarios and different battle stages, the information that users pay attention to, the way that users want to display information and the way that users want to input information can be obtained. Firstly, the task scene is modeled, and the current task scene can be sensed in real time. Secondly, the user behavior under the current scenario is collected and stored in the user behavior analysis sample database. Finally, the user behavior analysis model is constructed, and the model outputs the content that the current user pays attention to, the desired presentation way and the desired information input way. The mission-scenario-oriented information user concern mining technology is an important component of the mission-scenario-oriented information product adaptive service technology, which can support the collection of operational user behavior and the analysis of behavior rules in the interactive process of operational information. This technology mainly studied user interaction behavior preferences facing different task scenarios, and provides basis for information recommendation and information adaptive presentation

Research on Task Scenario-oriented Information User Concern Mining Technology

With the rapid evolution of war forms and the profound reform of combat forms, battlefield intelligence information will present complex and diverse characteristics. Faced with a large number of complex intelligence information, it is difficult for users to obtain the key information in the battlefield to make real-time decision aid by using traditional methods. Based on the analysis of user interaction behavior rules of intelligence users of different levels, different identities and different specialties facing different task scenarios and different battle stages, the information that users pay attention to, the way that users want to display information and the way that users want to input information can be obtained. Firstly, the task scene is modeled, and the current task scene can be sensed in real time. Secondly, the user behavior under the current scenario is collected and stored in the user behavior analysis sample database. Finally, the user behavior analysis model is constructed, and the model outputs the content that the current user pays attention to, the desired presentation way and the desired information input way. The mission-scenario-oriented information user concern mining technology is an important component of the mission-scenario-oriented information product adaptive service technology, which can support the collection of operational user behavior and the analysis of behavior rules in the interactive process of operational information. This technology mainly studied user interaction behavior preferences facing different task scenarios, and provides basis for information recommendation and information adaptive presentation

Bone‐to‐Bone Ligament Preserving Laminoplasty with Ultrasonic Osteotome Assistance for Intraspinal Tumors: A Technical Note and Clinical Follow‐Up

Objective Laminectomy has been widely used for intraspinal tumor resection. However, the tilted spinous process and narrow lateral laminae of the thoracic spine along with the hypertrophic ligamentum flavum of the lumbar spine pose certain problems for the laminae removal of the traditional laminectomy. We improved the laminectomy method with ultrasonic osteotome to treat thoracolumbar tumors and assessed its safety and superiority. Methods A retrospective analysis was performed in 86 patients with thoracolumbar (T4–L5) spinal tumors treated by resection, including 44 with the lamina removed using the traditional method and 42 with the lamina removed using the bone‐to‐bone ligament preserving (BLP) laminoplasty, which preserves the posterior ligament complex. Age, sex, and tumor size, location, and depth were compared between the two groups. The length of incision and bone window, time to remove the vertebral lamina, and epidural effusion volume were recorded at 2 weeks after surgery in the two groups. Postoperative reexamination by magnetic resonance imaging (MRI) at 2 weeks and 3 months after surgery was compared with preoperative MRI to assess the change in vertebral lamina displacement. Results There were no statistical differences in age, sex, and tumor size, depth, or location between the two groups. The BLP laminectomy did not increase the risk of dural, spinal cord, or nerve injuries. The difference between the incision and tumor length, as well as the difference between the bone window and tumor length in the BLP laminectomy group, were smaller than those in the traditional laminectomy group, and the BLP laminectomy took less time compared to that of the traditional laminectomy (p < 0.05). There was no significant difference in the volume of epidural effusion between the two groups at 2 weeks postoperatively, or in the displacement of the returned vertebral plate observed in sagittal and axial positions. The same was true for the displacement at 3 months postoperatively in the axial position. However, the sagittal displacement in the BLP laminectomy group was smaller than that in the traditional laminectomy group (p < 0.05). Conclusions The BLP laminectomy is safe for the resection of thoracolumbar spinal canal tumors. It is less traumatic and faster, with less displacement of the returned lamina, resulting in a stable repair of the spine

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

Abstract Background ALKBH5 regulated the malignant behavior of breast cancer and glioblastoma. However, the expression and function of ALKBH5 in epithelial ovarian cancer have not yet been determined. In the present study, we investigated the expression and function of ALKBH5 in epithelial ovarian cancer with respect to its potential role in the tumorigenesis of the disease as well as an early diagnostic marker. Methods Immunohistochemistry and western blot were used to detect protein expression. Gene silencing and over-expression experiment were used to study gene function. Cell proliferation assay and Matrigel invasion assays were used to detect cell proliferation and invasion, respectively. The nude mouse tumor formation experiment was used to evaluate the growth of cells in vivo. Results The expression of ALKBH5 was found to be increased in epithelial ovarian cancer tissue as compared to the normal ovarian tissues. The silencing of ALKBH5 in SKOV3 cells enhanced the autophagy and inhibited the proliferation and invasion in vitro and in vivo, whereas the ectopic expression of ALKBH5 in A2780 cells exerted an opposite effect. Mechanical study revealed that ALKBH5 physically interacted with HuR. ALKBH5 activated EGFR-PIK3CA-AKT-mTOR signaling pathway. Also, ALKBH5 enhanced the stability of BCL-2 mRNA and promoted the interaction between Bcl-2 and Beclin1. Conclusion Overall, the present study identified ALKBH5 as a candidate oncogene in epithelial ovarian cancer and a potential target for ovarian cancer therapy

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive. Here, we show the critical importance of tumor-derived TLR2 ligands in the generation of immunosuppressive IL-10-producing human and mouse DCs. TLR2 ligation induced two parallel synergistic processes that converged to activate STAT3: stimulation of autocrine IL-6 and IL-10 and upregulation of their respective cell surface receptors, which lowered the STAT3 activation threshold. We identified versican as a soluble tumor-derived factor that activates TLR2 in DCs. TLR2 blockade in vivo improved intra-tumor DC immunogenicity and enhanced the efficacy of immunotherapy. Our findings provide a basis for understanding the molecular mechanisms of DC dysfunction in cancer and identify TLR2 as a relevant therapeutic target to improve cancer immunotherapy

The Eco-Friendly Biochar and Valuable Bio-Oil from Caragana korshinskii: Pyrolysis Preparation, Characterization, and Adsorption Applications

Carbonization of biomass can prepare carbon materials with excellent properties. In order to explore the comprehensive utilization and recycling of Caragana korshinskii biomass, 15 kinds of Caragana korshinskii biochar (CB) were prepared by controlling the oxygen-limited pyrolysis process. Moreover, we pay attention to the dynamic changes of microstructure of CB and the by-products. The physicochemical properties of CB were characterized by Scanning Electron Microscope (SEM), BET-specific surface area (BET-SSA), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), and Gas chromatography-mass spectrometry (GC-MS). The optimal preparation technology was evaluated by batch adsorption application experiment of NO3&minus;, and the pyrolysis mechanism was explored. The results showed that the pyrolysis temperature is the most important factor in the properties of CB. With the increase of temperature, the content of C, pH, mesoporous structure, BET-SSA of CB increased, the cation exchange capacity (CEC) decreased and then increased, but the yield and the content of O and N decreased. The CEC, pH, and BET-SSA of CB under each pyrolysis process were 16.64&ndash;81.4 cmol&middot;kg&minus;1, 6.65&ndash;8.99, and 13.52&ndash;133.49 m2&middot;g&minus;1, respectively. CB contains abundant functional groups and mesoporous structure. As the pyrolysis temperature and time increases, the bond valence structure of C 1s, Ca 2p, and O 1s is more stable, and the phase structure of CaCO3 is more obvious, where the aromaticity increases, and the polarity decreases. The CB prepared at 650 &deg;C for 3 h presented the best adsorption performance, and the maximum theoretical adsorption capacity for NO3&minus; reached 120.65 mg&middot;g&minus;1. The Langmuir model and pseudo-second-order model can well describe the isothermal and kinetics adsorption process of NO3&minus;, respectively. Compared with other cellulose and lignin-based biomass materials, CB showed efficient adsorption performance of NO3&minus; without complicated modification condition. The by-products contain bio-soil and tail gas, which are potential source of liquid fuel and chemical raw materials. Especially, the bio-oil of CB contains &alpha;-d-glucopyranose, which can be used in medical tests and medicines

BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation

Atherosclerosis is a chronic systemic inflammatory disease that causes severe cardiovascular events. B cell lymphoma 2-associated athanogene (BAG3) was proven to participate in the regulation of tumor angiogenesis, neurodegenerative diseases, and cardiac diseases, but its role in atherosclerosis remains unclear. Here, we aim to investigate the role of BAG3 in atherosclerosis and elucidate the potential molecular mechanism. In this study, ApoE&minus;/&minus; mice were given a tail-vein injection of BAG3-overexpressing lentivirus and fed a 12-week high-fat diet (HFD) to investigate the role of BAG3 in atherosclerosis. The overexpression of BAG3 reduced plaque areas and improved atherosclerosis in ApoE&minus;/&minus; mice. Our research proves that BAG3 promotes autophagy in vitro, contributing to the suppression of EndMT in human umbilical vein endothelial cells (HUVECs). Mechanically, autophagy activation is mediated by BAG3 via the interaction between BAG3 and its chaperones HSP70 and HSPB8. In conclusion, BAG3 facilitates autophagy activation via the formation of the chaperone-assisted selective autophagy (CASA) complex interacting with HSP70 and HSPB8, leading to the inhibition of EndMT during the progression of atherosclerosis and indicating that BAG3 is a potential therapeutic target for atherosclerosis

Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Abstract Background Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case–control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women. Methods Four polymorphisms (rs2881766, rs9383951, rs9340799 in ESR1 and rs3020449 in ESR2) were genotyped in 459 patients and 549 healthy controls using the Sequenom MassARRAY method. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the associations. False-positive report probability (FPRP) was utilized to examine the noteworthiness of significant findings. Results We observed that rs2881766 was associated with a decreased BC risk (GG vs. TT: OR = 0.63, 95% CI = 0.44–0.91; GG vs. TT/GT: OR = 0.68, 95% CI = 0.49–0.95), while rs3020449 was associated with an increased risk of BC (CT vs. TT: OR = 1.58, 95% CI = 1.21–2.06; CT/CC vs. TT: OR = 1.54, 95% CI = 1.20–1.98; TT/CC vs. CT: OR = 1.48, 95% CI = 1.15–1.90). The other two polymorphisms have no relation with BC susceptibility. In addition, rs2881766 was correlated with lymph node metastasis and ER expression, and rs3020449 was related to tumor size, histological grade and ER expression. The values of false-positive report probability indicated that the significant associations of BC risk with both rs2881766 and rs3020449 were noteworthy. Conclusions Our study suggests that polymorphisms rs2881766 and rs3020449 in estrogen receptor genes were associated with BC susceptibility as well as clinical features in Chinese women. These findings need further validation in a large population