Ethyl 1-[(4-acetyl-2-methoxy­phen­oxy)meth­yl]cyclo­propane-1-carboxyl­ate

In the title compound, C16H20O5, the dihedral angle between the planar rings, viz. benzene and cyclo­propane, is 52.1 (2)°. Mol­ecules are connected in the crystal via weak inter­molecular C—H⋯O hydrogen bonds, forming chains in the [001] direction

Differences between physical and human process simulation in geography: Empirical analysis of two cases

National Natural Science Foundation of China 41125005;Chinese Academy of Sciences KACX1-YW-1001Physical geography and human geography are the principal branches of the geographical sciences. Physical process simulation and human process simulation in geography are both quantitative methods used to recover past events and even to forecast events based on precisely determined parameters. There are four differences between physical process simulation and human process simulation in geography, which we summarize with two specific cases, one of which is about a typhoon's development and its precipitation, and the other of which is regarding the evolution of three industrial structures in China. The differences focus on four aspects: the main factors of the research framework; the knowledge background of the systematic analysis framework; the simulation data sources and quantitative method; and the core of the study object and the method of forecast application. As the human-land relationship is the key ideology of the man-land system, the relationship between the physical and human factors is becoming increasingly close at present. Physical process simulation and human process simulation in geography will exhibit crossing and blending in the future to reflect the various geographical phenomena better

Disentangled Representation Learning

Disentangled Representation Learning (DRL) aims to learn a model capable of identifying and disentangling the underlying factors hidden in the observable data in representation form. The process of separating underlying factors of variation into variables with semantic meaning benefits in learning explainable representations of data, which imitates the meaningful understanding process of humans when observing an object or relation. As a general learning strategy, DRL has demonstrated its power in improving the model explainability, controlability, robustness, as well as generalization capacity in a wide range of scenarios such as computer vision, natural language processing, data mining etc. In this article, we comprehensively review DRL from various aspects including motivations, definitions, methodologies, evaluations, applications and model designs. We discuss works on DRL based on two well-recognized definitions, i.e., Intuitive Definition and Group Theory Definition. We further categorize the methodologies for DRL into four groups, i.e., Traditional Statistical Approaches, Variational Auto-encoder Based Approaches, Generative Adversarial Networks Based Approaches, Hierarchical Approaches and Other Approaches. We also analyze principles to design different DRL models that may benefit different tasks in practical applications. Finally, we point out challenges in DRL as well as potential research directions deserving future investigations. We believe this work may provide insights for promoting the DRL research in the community.Comment: 22 pages,9 figure

STUDY ON THE CORRELATION OF WATER QUALITY FACTORS WITH SPECIES DISTRIBUTION OF MANGANESE IN WEST LAKE

In this paper, changes in water quality factors of West Lake and variations in the speciation distribution of Manganese in both water and bottom sediment from June 1995 to May 1996 was reported. The correlation of manganese species distribution with water quality factors was also investigated. The results showed that besides TP, T, TIN, and chl-a etc., Manganese was also one of the main factors which affects water transparency.Article信州大学理学部附属諏訪臨湖実験所報告 11: 73-77(1999)departmental bulletin pape

Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma

<p>Abstract</p> <p>Purpose</p> <p>To evaluate the clinical efficacy and toxicity of stereotactic body radiation therapy (SBRT) using extracranial gamma knife in patients with mainly bulky inoperable early stage non-small cell lung carcinoma (NSCLC).</p> <p>Materials and methods</p> <p>A total of 43 medically inoperable patients with mainly bulky Stage I/II NSCLC received SBRT using gamma knife were reviewed. The fraction dose and the total dose were determined by the radiation oncologist according to patients' general status, tumor location, tumor size and the relationship between tumor and nearby organ at risk (OAR). The total dose of 34~47.5 Gy was prescribed in 4~12 fractions, 3.5~10 Gy per fraction, one fraction per day or every other day. The therapeutic efficacy and toxicity were evaluated.</p> <p>Results</p> <p>The median follow-up was 22 months (range, 3-102 months). The local tumor response rate was 95.35%, with CR 18.60% (8/43) and PR 76.74% (33/43), respectively. The local control rates at 1, 2, 3, 5 years were 77.54%, 53.02%, 39.77%, and 15.46%, respectively, while the 1- and 2-year local control rates were 75% and 60% for tumor ≤3 cm; 84% and 71% for tumor sized 3~5 cm; 55% and 14.6% for tumor sized 5~7 cm; and 45%, 21% in those with tumor size of >7 cm. The overall survival rate at 1, 2, 3, 5 years were 92.04%, 78.04%, 62.76%, 42.61%, respectively. The toxicity of stereotactic radiation therapy was grade 1-2. Clinical stages were significantly important factor in local control of lung tumors (P = 0.000). Both clinical stages (P = 0.015) and chemotherapy (P = 0.042) were significantly important factors in overall survival of lung tumors.</p> <p>Conclusion</p> <p>SBRT is an effective and safe therapy for medically inoperable patients with early stage NSCLC. Clinical stage was the significant prognostic factors for both local tumor control and overall survival. The toxicity is mild. The overall local control for bulky tumors is poor. Tumor size is a poor prognostic factor, and the patients for adjuvant chemotherapy need to be carefully selected.</p