Nonlinearly scalarized rotating black holes in Einstein-scalar-Gauss-Bonnet theory

In this paper, we discuss a fully nonlinear mechanism for the formation of scalarized rotating black holes in Einstein-scalar-Gauss-Bonnet gravity, where Kerr black holes are linearly stable, but unstable against nonlinear scalar perturbations. With the help of the pseudospectral method, we obtain a spectrum of nonlinearly scalarized rotating black hole solutions with multiple scalarized branches. Moreover, we investigate the thermodynamic properties of nonlinearly scalarized rotating black holes and find the phase transition between Kerr and these scalarized black holes.Comment: 23 pages, 8 figures and 2 table

Spin-Charge induced spontaneous scalarization of Kerr-Newman black holes

We investigate the tachyonic instability of Kerr-Newman (KN) black holes in the Einstein-Maxwell-scalar (EMS) theory with a positive coupling parameter $\alpha$. This corresponds to exploring the onset of spontaneous scalarization for KN black holes. For this purpose, we use the hyperboloidal foliation method (HFM) to solve the linearized scalar equation numerically. We obtain a 3D graph [$\log_{10}\alpha(a,Q)$] which indicates the onset surface for spontaneous scalarization of KN black holes in the EMS theory. We find that there is no lower bound on the rotational parameter $a$, but its upper bound is given by $M^2-Q^2 \ge a^2$. Also, we confirm that the high rotation enhances spontaneous scalarization of KN black holes in the EMS theory.Comment: 21 pages, 6 figures, Version accepted for publication in PRD. arXiv admin note: text overlap with arXiv:2206.1158

Does PGA external stenting reduce compliance mismatch in venous grafts?

BACKGROUND: Autogenous vein grafting is widely used in regular bypassing procedures. Due to its mismatch with the host artery in both mechanical property and geometry, the graft often over expands under high arterial blood pressure and forms a step-depth where eddy flow develops, thus causing restenosis, fibrous graft wall, etc. External stents, such as sheaths being used to cuff the graft, have been introduced to eliminate these mismatches and increase the patency. Although histological and immunochemical studies have shown some positive effects of the external stent, the mechanical mismatch under the protection of an external stent remains poorly analyzed. METHODS: In this study, the jugular veins taken from hypercholesterolemic rabbits were transplanted into the carotid arteries, and non-woven polyglycolic acid (PGA) fabric was used to fabricate the external stents to study the effect of the biodegradable external stent. Eight weeks after the operation, the grafts were harvested to perform mechanical tests and histological examinations. An arc tangent function was suggested to describe the relationship between pressure and cross-sectional area to analyse the compliance of the graft. RESULTS: The results from the mechanical tests indicated that grafts either with or without external stents displayed large compliance in the low-pressure range and were almost inextensible in the high-pressure range. This was very different from the behavior of the arteries or veins in vivo. The data from histological tests showed that, with external stents, collagen fibers were more compact, whilst those in the graft without protection were looser and thicker. No elastic fiber was found in either kind of grafts. Furthermore, grafts without protection were over-expanded which resulted in much bigger cross-sectional areas. CONCLUSION: The PGA external extent contributes little to the reduction of the mechanical mismatch between the graft and its host artery while remodeling develops. For the geometric mismatch, it reduces the cross-section area, therefore matching with the host artery much better. Although there are some positive effects, conclusively the PGA is not an ideal material for external stent.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Application potential of grain and oil processing by-products in research of microbial-oriented food

Hundreds of millions of bacteria adhere to human intestinal epithelium,which are the participants of human health and physiological functions,and also an important target covered by the concept of comprehensive health.So far,the supplementation of prebiotics remainsare still one of the effective means to regulate intestinal microbiota and promote the growth of beneficial microbes.The by-productsof grain and oil processing are abundant in variety and yield,and many of them can be utilized by human intestinal microbiota,which are one of the sources of high-quality prebiotics,and also the important material basis and raw material source in the development of “microbial-oriented food”

SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C

<p>Abstract</p> <p>Background</p> <p><it>Salmonella paratyphi </it>C is one of the few human-adapted pathogens along with <it>S. typhi, S. paratyphi </it>A and <it>S. paratyphi </it>B that cause typhoid, but it is not clear whether these bacteria cause the disease by the same or different pathogenic mechanisms. Notably, these typhoid agents have distinct sets of large genomic insertions, which may encode different pathogenicity factors. Previously we identified a novel prophage, SPC-P1, in <it>S. paratyphi </it>C RKS4594 and wondered whether it might be involved in pathogenicity of the bacteria.</p> <p>Results</p> <p>We analyzed the sequence of SPC-P1 and found that it is an inducible phage with an overall G+C content of 47.24%, similar to that of most <it>Salmonella </it>phages such as P22 and ST64T but significantly lower than the 52.16% average of the RKS4594 chromosome. Electron microscopy showed short-tailed phage particles very similar to the lambdoid phage CUS-3. To evaluate its roles in pathogenicity, we lysogenized <it>S. paratyphi </it>C strain CN13/87, which did not have this prophage, and infected mice with the lysogenized CN13/87. Compared to the phage-free wild type CN13/87, the lysogenized CN13/87 exhibited significantly increased virulence and caused multi-organ damages in mice at considerably lower infection doses.</p> <p>Conclusions</p> <p>SPC-P1 contributes pathogenicity to <it>S. paratyphi </it>C in animal infection models, so it is possible that this prophage is involved in typhoid pathogenesis in humans. Genetic and functional analyses of SPC-P1 may facilitate the study of pathogenic evolution of the extant typhoid agents, providing particular help in elucidating the pathogenic determinants of the typhoid agents.</p

Soybean GmPHD-Type Transcription Regulators Improve Stress Tolerance in Transgenic Arabidopsis Plants

Soybean [Glycine max (L.) Merr.] is one of the most important crops for oil and protein resource. Improvement of stress tolerance will be beneficial for soybean seed production.Six GmPHD genes encoding Alfin1-type PHD finger protein were identified and their expressions differentially responded to drought, salt, cold and ABA treatments. The six GmPHDs were nuclear proteins and showed ability to bind the cis-element "GTGGAG". The N-terminal domain of GmPHD played a major role in DNA binding. Using a protoplast assay system, we find that GmPHD1 to GmPHD5 had transcriptional suppression activity whereas GmPHD6 did not have. In yeast assay, the GmPHD6 can form homodimer and heterodimer with the other GmPHDs except GmPHD2. The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization. Transgenic Arabidopsis plants overexpressing the GmPHD2 showed salt tolerance when compared with the wild type plants. This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes.These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator