FDserver: A web service for protein folding research

*Summary:* To facilitate the study of protein folding, we have developed a web service for protein folding rate and folding type prediction as well as for the calculation of a variety of topological parameters of protein structure, which is freely available to the community.
*Availability:* http://sdbi.sdut.edu.cn/FDserve

Adversarial Network Bottleneck Features for Noise Robust Speaker Verification

In this paper, we propose a noise robust bottleneck feature representation which is generated by an adversarial network (AN). The AN includes two cascade connected networks, an encoding network (EN) and a discriminative network (DN). Mel-frequency cepstral coefficients (MFCCs) of clean and noisy speech are used as input to the EN and the output of the EN is used as the noise robust feature. The EN and DN are trained in turn, namely, when training the DN, noise types are selected as the training labels and when training the EN, all labels are set as the same, i.e., the clean speech label, which aims to make the AN features invariant to noise and thus achieve noise robustness. We evaluate the performance of the proposed feature on a Gaussian Mixture Model-Universal Background Model based speaker verification system, and make comparison to MFCC features of speech enhanced by short-time spectral amplitude minimum mean square error (STSA-MMSE) and deep neural network-based speech enhancement (DNN-SE) methods. Experimental results on the RSR2015 database show that the proposed AN bottleneck feature (AN-BN) dramatically outperforms the STSA-MMSE and DNN-SE based MFCCs for different noise types and signal-to-noise ratios. Furthermore, the AN-BN feature is able to improve the speaker verification performance under the clean condition