MicroRNAs expression profile of gefitinib resistant non-small cell lung cancer HCC827 cells

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib are promising therapies for patients with non-small-cell lung cancer (NSCLC). Patients with somatic activating mutations in the EGFR gene have dramatic response initially; however, these patients eventually develop resistance to these TKIs. Subsequent studies found that a secondary mutation in the EGFR gene (T790M mutation) and amplification of the c-MET could be the two main resistance mechanism involved. Other mechanisms are still unknown. Recently, MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators which are known in the regulation of gene expression for cell development, cell proliferation, radiotherapy and chemotherapy resistance and apoptotic cell death.  The aim of this study was to investigate miRNA expression profiles involved in the development of gefitinib resistance in NSCLC. Here, miRNA microarray assay was employed to identify miRNA expression profiles in gefitinib-resistant HCC827 cells (HCC827/GR) and parental HCC827 cells (HCC827/P). The comparison of miRNA expression between HCC827/GR and HCC827/P cell lines identified the differential expression of sixty-five miRNAs with eight significantly upregulated miRNAs (miRNA-198, miR-202, miR-210, miRNA-214, miR-22, miR-27a, miR-296-3p and miR-208b) and fourteen greatly downregulated miRNAs (miR-135b, miR-141, miR-145, miR-153, miR-181c, miR-181d, miR-188-3p, miR-197, miR-200c, miR-206-3, miR-215, miR-216a, miR-296-5p and miR-30a). The investigation of miRNA expression profiles in HCC827/GR cells could provide a better understanding of mechanisms involved in gefitinib resistance or sensitivity which would be helpful to develop novel strategies to overcome gefitinib resistance of patients with NSCLC

A long range, energy efficient internet of things based drought monitoring system

The climate change and global warning have been appeared as an emerging issue in recent decades. In which, the drought problem has been influenced on economics and life condition in Vietnam. In order to solve this problem, in this paper, we have designed and deployed a long range and energy efficient drought monitoring based on IoT (Internet of Things) for real time applications. After being tested in the real condition, the proposed system has proved its high dependability and effectiveness. The system is promising to become a potential candidate to solve the drought problem in Vietnam

TÀI SẢN THƯƠNG HIỆU BÁO ĐIỆN TỬ VIỆT NAM: TỪ HÀI LÒNG ĐẾN TRUNG THÀNH THƯƠNG HIỆU

The study analyzes the intricate relationship between Brand Awareness, Brand Trust, Perceived Value, Brand Satisfaction, and Brand Loyalty in the context of e-newspaper brands in Vietnam. Data was collected in both face-to-face and online forms from 303 e-readers of the most popular e-newspapers nowadays, as follows: VnExpress, Dantri, VietNamNet, Tuoi Tre, and Thanh Nien. Collected data are filtered, processed, and analyzed by the PLS-SEM structural model using the SmartPLS tool. The research results have provided an empirical basis for the positive impact of factors influencing brand loyalty and the mediating role of brand satisfaction in the context of e-newspaper brands in Vietnam, thereby contributing enormously to the theoretical basis of the brand equity model.Nghiên cứu phân tích mối quan hệ phức tạp giữa các yếu tố Nhận thức thương hiệu, Niềm tin thương hiệu, Giá trị cảm nhận, Hài lòng thương hiệu và Trung thành thương hiệu trong bối cảnh thương hiệu báo điện tử ở Việt Nam dựa trên lý thuyết về mô hình tài sản thương hiệu CBBE (Customer-based Brand Equity). Dữ liệu điều tra được thu thập bằng hình thức trực tiếp và trực tuyến đối với 303 độc giả số của các trang báo điện tử phố biến nhất hiện nay như: VnExpress, Dân trí, VietNamNet, Tuổi Trẻ và Thanh Niên. Dữ liệu thu thập được làm sạch, xử lý và tiến hành phân tích mô hình cấu trúc PLS-SEM bằng công cụ SmartPLS. Kết quả nghiên cứu đã cung cấp một cơ sở thực chứng về tác động tích cực của các nhân tố ảnh hưởng đến sự trung thành thương hiệu và vai trò trung gian của sự hài lòng thương hiệu trong bối cảnh thương hiệu báo điện tử ở Việt Nam, từ đó đóng góp vào cơ sở lý thuyết về mô hình tài sản thương hiệu

ẢNH HƯỞNG CỦA CÔNG NGHỆ THỰC TẾ ẢO TĂNG CƯỜNG ĐẾN Ý ĐỊNH MUA HÀNG TRỰC TUYẾN CỦA NGƯỜI TIÊU DÙNG

The study shows the effects of factors affecting consumers' purchase intention after experiencing Virtual Try-on (VTO) in Vietnam. The study is carried out by quantitative method through data from 408 subjects of different ages in Hanoi and Northern provinces. The findings of the study demonstrate that perceived usefulness, perceived ease of use, perceived enjoyment, and perceived privacy risk, have a significant impact on users' attitudes toward Virtual Try-On (VTO). Consequently, these factors increase their influence on customers' purchase intentions. Based on these results, the research group recommends that, in practical settings, enterprises concentrate on providing high-quality services, promoting their products to augment the aforementioned factors, and simultaneously addressing users' attitudes to enhance the overall customer experience. Therefore, this study provides valuable insights into the factors that influence customers' attitudes toward VTO technology, thereby contributing to the existing literature on the topic.Nghiên cứu chỉ ra những tác động của các nhân tố ảnh hưởng tới ý định mua hàng của người tiêu dùng qua hành vi sử dụng công nghệ trải nghiệm sản phẩm trực tuyến (Virtual Try-on - VTO) tại Việt Nam. Phương pháp định lượng được sử dụng để phân tích dữ liệu từ 408 đối tượng trong nhiều độ tuổi khác nhau trên địa bàn thành phố Hà Nội và các tỉnh thành phố miền Bắc. Kết quả cho thấy rằng các nhân tố như cảm nhận tính hữu ích, cảm nhận tính dễ sử dụng, cảm nhận tính thích thú, và cảm nhận rủi ro về quyền riêng tư có tác động đến thái độ của người dùng với công nghệ VTO từ đó gia tăng ảnh hưởng tới ý định mua sắm của khách hàng. Nhóm nghiên cứu đề xuất rằng, trong bối cảnh thực tiễn, doanh nghiệp cần tập trung vào cung cấp dịch vụ chất lượng, quảng bá sản phẩm để nâng cao các yếu tố đã được đề cập, đồng thời quan tâm đến thái độ của người dùng để cải thiện trải nghiệm tích cực cho khách hàng

Urban Residents to Finance Public Parks’ Tree-planting Projects: An Investigation of Biodiversity Loss Consequence Perceptions and Park Visit Frequency

Public parks play important roles in conserving biodiversity, promoting environmental sustainability, fostering community engagement, and enhancing the overall well-being of residents in urban areas. Nevertheless, finance is needed to maintain and expand the greenspaces in the parks. The current study aims to examine how perceptions of biodiversity loss consequences and park visitation frequency influence the residents’ willingness to contribute financially to tree-planting projects in public parks. Employing the Bayesian Mindsponge Framework analytics on a dataset of 535 Vietnamese urban residents, we discovered that perceived health loss and knowledge erosion as consequences of biodiversity loss and park visitation frequency are directly positively associated with financial donation willingness. Meanwhile, the perceived economic growth loss was found to be indirectly positively associated with donation willingness through park visitation frequency, whereas the perceived loss of nature-based recreation opportunities exhibits the opposite indirect association. Based on these results, communication strategies focusing on the multifaceted benefits of biodiversity preservation and investments in public parks are recommended to improve urban residents’ financial support to park panting initiatives, accessibility to greenspaces, and connections with nature. These are crucial for promoting an eco-surplus culture that enhances biodiversity conservation and human well-being

Exploring Italian Consumers’ Willingness to Pay for Sustainable Fashion: The Roles of Eco-Consciousness and Vintage Preference

Studying the psychology behind the purchase of eco-friendly products and second-hand items can offer valuable insights to promote sustainable consumer behavior. This paper examines factors influencing Italian consumers’ willingness to pay regarding bio-based clothing and second-hand items. Drawing from data collected from 402 Italian participants, we examine how motivations and socio-demographic factors are associated with willingness to pay in the context of sustainable fashion. Our findings reveal that motivations related to environmental concerns are positively associated with consumers’ willingness to pay higher premiums for bio-based clothing. Higher income and education levels are also associated with the willingness to pay higher premiums. Meanwhile, motivation related to vintage appeal is associated with lower desired discounts for second-hand items, particularly among older consumers. Gender differences also influence discount preferences, with men seeking larger discounts on second-hand clothing compared to women. By providing insights into Italian consumers’ sustainable fashion choices, this study offers implications for businesses, policymakers, and researchers aiming to promote eco-conscious consumption and sustainability in the fashion industry

Functional-Antioxidant Food

Nowadays, people face many different dangers, such as stress, unsafety food, and environmental pollution, but not everyone suffers. Meanwhile, free radicals are the biggest threat for humans because they lead to over 80 different diseases composed of aging. Free radicals can only be eliminated or minimized with antioxidant foods or antioxidants. The chapter on the functional-antioxidant food presents the antioxidant functional food concept, the classification, the structure, and the extraction process of antioxidant ingredients. Various antioxidant substances such as protein (collagen), polysaccharides (fucoidans, alginates, glucosamines, inulins, laminarins, ulvans, and pectins), and secondary metabolites (polyphenols (phlorotannins, lignins, polyphenols), alkaloids, and flavonoids) also present. The production technology, the mechanism, the opportunity, and the challenge of antioxidants functional food also present in the current chapter. The current chapter also gives the production process of functional-antioxidant food composed of the capsule, the tablet, tube, the pills, the powder, and the effervescent tablet

Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of cardiovascular disturbance is less clear, but is believed to relate to disinhibition of the autonomic nervous system. The clinical syndrome of autonomic nervous system dysfunction (ANSD) seen in severe tetanus is characterized principally by changes in heart rate and blood pressure which have been linked to increased circulating catecholamines. Previous studies have described varying relationships between catecholamines and signs of ANSD in tetanus, but are limited by confounders and assays used. In this study, we aimed to perform detailed characterization of the relationship between catecholamines (adrenaline and noradrenaline), cardiovascular parameters (heart rate and blood pressure) and clinical outcomes (ANSD, mechanical ventilation required, and length of intensive care unit stay) in adults with tetanus, as well as examine whether intrathecal antitoxin administration affected subsequent catecholamine excretion. Noradrenaline and adrenaline were measured by ELISA from 24-h urine collections taken on day 5 of hospitalization in 272 patients enrolled in a 2 × 2 factorial-blinded randomized controlled trial in a Vietnamese hospital. Catecholamine results measured from 263 patients were available for analysis. After adjustment for potential confounders (i.e., age, sex, intervention treatment, and medications), there were indications of non-linear relationships between urinary catecholamines and heart rate. Adrenaline and noradrenaline were associated with subsequent development of ANSD, and length of ICU stay