Signature of Pseudo Nambu-Goldstone Higgs boson in its Decay

If the Higgs boson is a pseudo Nambu-Goldstone boson (PNGB), the $hZ\gamma$ contact interaction induced by the $\mathcal{O}(p^4)$ invariants of the non-linear sigma model is free from its nonlinearity effects. The process $h\rightarrow Z\gamma$ can be used to eliminate the universal effects of heavy particles, which can fake the nonlinearity effects of the PNGB Higgs boson in the process $h\rightarrow V^*V$ ($V=W^\pm$,\ $Z$). We demonstrate that the ratio of the signal strength of $h\rightarrow Z\gamma$ and $h\rightarrow V^*V$ is good to distinguish the signature of the PNGB Higgs boson from Higgs coupling deviations

Ethyl 2-(3,3-dibutyl­thio­ureido)-4,5,6,7-tetra­hydro­benzo[b]thio­phene-3-carboxyl­ate

In the title compound, C20H32N2O2S2, the cyclo­hexene ring is disordered over two half-boat conformations with occupancy factors of 0.71:0.29. One n-butyl chain is also disordered over two positions with occupancy factors of 0.83:0.17. The mol­ecular conformation is stabilized by an intra­molecular N—H⋯O hydrogen bond

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans

This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis

Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate

The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C15H12ClNO7S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. In the crystal, mol­ecules are linked through C—H⋯O interactions, and there is also a short Cl⋯O contact present [Cl⋯O = 3.018 (2) Å]