Interpretation of the "fDsf_{D_s} puzzle" in SM and beyond

The recent measurement on the decay constant of $D_s$ shows a discrepancy between theory and experiment. We study the leptonic and semileptonic decays of $D$ and $D_s$ simultaneously within the standard model by employing a lightfront quark model. There is space by tuning phenomenological parameters which can explain the "$f_{D_s}$ puzzle" and do not contradict other experiments on the semileptonic decays. We also investigate the leptonic decays of D and $D_{s}$ with a new physics scenario, unparticle physics. The unparticle effects induce a constructive interference with the standard model contribution. The nontrivial phase in unparticle physics could produce direct CP violation which may distinguish it from other new physics scenarios.Comment: 16 pages, 6 figures, be accepted by PR

A novel model for synthesizing parallel I/O workloads in scientific applications

Abstract — One of the challenging issues in performance eval-uation of parallel storage systems through synthetic-trace-driven simulation is to accurately characterize the I/O demands of data-intensive scientific applications. This paper analyzes several I/O traces collected from different distributed systems and concludes that correlations in parallel I/O inter-arrival times are inconsistent, either with little correlation or with evident and abundant correlations. Thus conventional Poisson or Markov arrival processes are inappropriate to model I/O arrivals in some applications. Instead, a new and generic model based on the α-stable process is proposed and validated in this paper to accurately model parallel I/O burstiness in both workloads with little and strong correlations. This model can be used to generate reliable synthetic I/O sequences in simulation studies. Experimental results presented in this paper show that this model can capture the complex I/O behaviors of real storage systems more accurately and faithfully than conventional models, particularly for the burstiness characteristics in the parallel I/O workloads. I

trans-Bis[4-amino-N-(pyrimidin-2-yl)benzene­sulfonamidato]dipyridine­cobalt(II) hemihydrate

The asymmeric unit of the title compound, [Co(C10H9N4O2S)2(C5H5N)2]·0.5H2O, contains the distorted octa­hedral trans-[Co(sdz)2(py)2] (sdz is the sulfadiazine anion and py is pyridine) complex mol­ecule and a half-mol­ecule of water, which lies on a twofold rotation axis. A three-dimensional network is generated by N—H⋯O and O—H⋯O hydrogen bonds between the complex and the water mol­ecules

Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features

The aim of this study was to evaluate the expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma (PFTC), as well as their correlations with clinicopathologic features. We studied a cohort of 33 patients with a pathological diagnosis of PFTC. Thirty normal tubal tissues used for controls were obtained from patients diagnosed with uterine myomas. Expression analysis for COX-2 and Bcl-2 was performed using the immunohistochemical technique. The rate of preoperative diagnosis was 18.2%. With a median survival of 61.0 months (95% CI: 43.2 to 78.8 months), the estimated five-year overall survival rate in the 33 patients was 39.0%. Increased expression of COX-2 and Bcl-2 was observed in tumor specimens compared to normal controls (p = 0.026; p = 0.003). The expression rate of COX-2 in node-positive tumors was significantly higher than that of node-negative tumors (p = 0.024). Moreover, the expression rate of COX-2 was statistically significantly higher in patients with infiltration through the serosa (p = 0.019). Positive significant associations were observed between Bcl-2 staining index and FIGO stage (p = 0.015), and between Bcl-2 staining and lymph node metastasis (p = 0.010). There was a significant correlation between COX-2 expression and Bcl-2 staining index (r = 0.517, p = 0.002). We conclude that COX-2 and Bcl-2 may potentially be useful prognostic markers for PFTC. The exact molecular mechanism for correlations between COX-2 and Bcl-2 remains to be elucidated. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 389–397

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.

Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. Genetic and pharmacological inhibition of RORγ reduces tumor cholesterol content and synthesis rate while preserving host cholesterol homeostasis. We demonstrate that RORγ functions as an essential activator of the entire cholesterol-biosynthesis program, dominating SREBP2 via its binding to cholesterol-biosynthesis genes and its facilitation of the recruitment of SREBP2. RORγ inhibition disrupts its association with SREBP2 and reduces chromatin acetylation at cholesterol-biosynthesis gene loci. RORγ antagonists cause tumor regression in patient-derived xenografts and immune-intact models. Their combination with cholesterol-lowering statins elicits superior anti-tumor synergy selectively in TNBC. Together, our study uncovers a master regulator of the cholesterol-biosynthesis program and an attractive target for TNBC