Lipolytic effect of compounds isolated from leaves of mulberry (<i>Morus alba</i> L.) in 3T3-L1 adipocytes

<p>In this study, 19 known compounds were isolated from mulberry (<i>Morus alba</i> L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds <b>4</b> and <b>12</b> showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds <b>3</b>, <b>6</b> and <b>15</b> showed significant inhibitory activity with values from 15.4 to 21.2% and compounds <b>2</b>, <b>8</b>–<b>9</b> and <b>17</b>–<b>18</b> exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.</p