6,986 research outputs found
Nodeless superconductivity in IrPtTe with strong spin-orbital coupling
The thermal conductivity of superconductor IrPtTe
( = 0.05) single crystal with strong spin-orbital coupling was measured down
to 50 mK. The residual linear term is negligible in zero magnetic
field. In low magnetic field, shows a slow field dependence. These
results demonstrate that the superconducting gap of IrPtTe is
nodeless, and the pairing symmetry is likely conventional s-wave, despite the
existence of strong spin-orbital coupling and a quantum critical point.Comment: 5 pages, 4 figure
Metabolic perturbations associated with the consumption of a ketogenic medium-chain TAG diet in dogs with idiopathic epilepsy
Consumption of diets containing medium-chain TAG (MCT) has been shown to confer neuroprotective effects. We aim to identify the global metabolic perturbations associated with consumption of a ketogenic diet (medium-chain TAG diet (MCTD)) in dogs with idiopathic epilepsy. We used ultra-performance liquid chromatography-MS (UPLC-MS) to generate metabolic and lipidomic profiles of fasted canine serum and made comparisons between the MCTD and standardised placebo diet phases. We identified metabolites that differed significantly between diet phases using metabolite fragmentation profiles generated by tandem MS (UPLC–MS/MS). Consumption of the MCTD resulted in significant differences in serum metabolic profiles when compared with the placebo diet, where sixteen altered lipid metabolites were identified. Consumption of the MCTD resulted in reduced abundances of palmitoylcarnitine, octadecenoylcarnitine, stearoylcarnitine and significant changes, both reduced and increased abundances, of phosphatidylcholine (PC) metabolites. There was a significant increase in abundance of the saturated C17 : 0 fatty acyl moieties during the MCTD phase. Lysophosphatidylcholine (17 : 0) (P=0·01) and PC (17:0/20:4) (P=0·03) were both significantly higher in abundance during the MCTD. The data presented in this study highlight global changes in lipid metabolism, and, of particular interest, in the C17 : 0 moieties, as a result of MCT consumption. Elucidating the global metabolic response of MCT consumption will not only improve the administration of current ketogenic diets for neurological disease models but also provides new avenues for research to develop better diet therapies with improved neuroprotective efficacies. Future studies should clarify the involvement and importance of C17 : 0 moieties in endogenous MCT metabolic pathways
Quasispecies distribution of Eigen model
We study sharp peak landscapes (SPL) of Eigen model from a new perspective
about how the quasispecies distribute in the sequence space. To analyze the
distribution more carefully, we bring forth two tools. One tool is the variance
of Hamming distance of the sequences at a given generation. It not only offers
us a different avenue for accurately locating the error threshold and
illustrates how the configuration of the distribution varies with copying
fidelity in the sequence space, but also divides the copying fidelity into
three distinct regimes. The other tool is the similarity network of a certain
Hamming distance , by which we can get a visual and in-depth result
about how the sequences distribute. We find that there are several local optima
around the center (global optimum) in the distribution of the sequences
reproduced near the threshold. Furthermore, it is interesting that the
distribution of clustering coefficient follows lognormal distribution
and the curve of clustering coefficient of the network versus
appears as linear behavior near the threshold.Comment: 13 pages, 6 figure
Multi-graph-view subgraph mining for graph classification
© 2015, Springer-Verlag London. In this paper, we formulate a new multi-graph-view learning task, where each object to be classified contains graphs from multiple graph-views. This problem setting is essentially different from traditional single-graph-view graph classification, where graphs are collected from one single-feature view. To solve the problem, we propose a cross graph-view subgraph feature-based learning algorithm that explores an optimal set of subgraphs, across multiple graph-views, as features to represent graphs. Specifically, we derive an evaluation criterion to estimate the discriminative power and redundancy of subgraph features across all views, with a branch-and-bound algorithm being proposed to prune subgraph search space. Because graph-views may complement each other and play different roles in a learning task, we assign each view with a weight value indicating its importance to the learning task and further use an optimization process to find optimal weight values for each graph-view. The iteration between cross graph-view subgraph scoring and graph-view weight updating forms a closed loop to find optimal subgraphs to represent graphs for multi-graph-view learning. Experiments and comparisons on real-world tasks demonstrate the algorithm’s superior performance
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