Liberal Studies and Servant Leadership: Inspiring Ignatian values at the margins

This paper aims to unpack how the concept of servant leadership is perceived from Liberal Studies graduates living at the margins of society. Anchoring this research in the work of Jesuit Worldwide Learning (JWL), a faith-based organization providing higher education to displaced and poor communities, this paper seeks to deconstruct the assumption present in the literature of an ‘already-in-power’ servant leader by inviting looking for servant leaders in vulnerable and marginalized places, where they would be most needed. By synthesizing the voices of more than 100 graduates from the Diploma in Liberal Studies program, this research looks at how graduates define servant leadership from the unprivileged perspective and how these graduates could develop and apply this approach in their daily life. Through this analysis, certain values and skills emerge, which permits a contribution to mapping a servant leader’s attributes. This paper concludes on the effect of democratizing the definition of servant leadership with the aims of serving a wider population and having a stronger impact on communities

Luminal Mg2+, A Key Factor Controlling RYR2-mediated Ca2+ Release: Cytoplasmic and Luminal Regulation Modeled in a Tetrameric Channel

In cardiac muscle, intracellular Ca2+ and Mg2+ are potent regulators of calcium release from the sarcoplasmic reticulum (SR). It is well known that the free [Ca2+] in the SR ([Ca2+]L) stimulates the Ca2+ release channels (ryanodine receptor [RYR]2). However, little is known about the action of luminal Mg2+, which has not been regarded as an important regulator of Ca2+ release

Temporal Horizons in Education

This paper extracts the findings of the impact study on the Learning Facilitator programme’s study, a 6-month blended learning professional programme accredited by the Catholic University of Eichstätt-Ingolstadt (Germany) and delivered by Jesuit Worldwide Learning to teachers in context of marginalisation. Focused on elucidating how the Learning Facilitator programme nurtures graduates' soft skills in teaching and fosters their servant-leadership, this paper underscores how the programme redefines the temporal horizons for its participants, enabling them to transcend established frames of reference and cultivate inclusive and conducive learning environments both within and beyond the confines of traditional classrooms. This contribution seeks to bring the seldom heard voices at the centre of the discussion on “time for education”, echoing graduates’ critical exploration in reevaluating conventional frames of reference in pedagogical contexts

Legal Training and Front Line of Criminal Defense

平成30年11月4日（日）に，第12回広島大学ホームカミングデー企画（法科大学院講演会）「刑事弁護の最前線と法曹養成」として，東千田未来創生センターにおいて，弁護士（大阪弁護士会）の亀石倫子氏，弁護士（広島弁護士会）で元広島大学大学院法務研究科教授の久保豊年氏を講師に迎え，第1部では講演会を，第2部では本研究科の新井誠教授，堀田尚徳准教授が加わりパネルディスカッションを開催しました。 本稿は，当日のテープ録音をもとに，その概要を報告するものです。（なお，講演会とパネルディスカッションに引き続き行われた，フロアとの質疑応答については，紙幅の関係上，省略させていただきました。

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

The central nervous system (CNS) is capable of gathering information on the body’s nutritional state and it implements appropriate behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus, to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the development of obesity and type 2 diabetes mellitus

Dietary and free n-3 polyunsaturated fatty acids modify calcium handling mechanisms in the heart / Bonny Honen.

Author's previous publications inserted.Bibliography: leaves 136-147.147 leaves : ill. ; 30 cm.It is well recognized that the consumption of fish correlates with a reduction in mortality due to cardiovascular disease. Whole heart studies have identified that dietary fish oil confers protection from cardiac arrhythmias. However, not all arrhythmias arise from disturbances in membrane electrical excitability, a class of arrhythmias arise from calcium mishandling. The aim of this thesis was to determine whether the antiarrhythmic actions of polyunsaturated fatty acids present in fish oil are due to modulation of calcium handling.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, Discipline of Physiology, 2003

Polyunsaturated dietary fats change the properties of calcium sparks in adult rat atrial myocytes

© 2002 Elsevier Science Inc. All rights reserved.This study investigated the effects of dietary omega-3 polyunsaturated fatty acids on calcium handling mechanisms in cardiac myocytes, with the hypothesis that this effect underlies some of the antiarrhythmic properties of these compounds. Adult male Sprague Dawley rats had their standard chow supplemented with either lard (57% saturated and 40% monounsaturated fat), canola oil (60% monounsaturated, 33% polyunsaturated) or fish oil (78% polyunsaturated). Isolated cardiac atrial myocytes from these animals were loaded with fluo-3AM and examined with laser scanning confocal microscopy. The dietary interventions resulted in considerable changes in the membrane phospholipid composition of cardiac cell membranes, particularly the ratio of n-6 to n-3 (2.17 with lard supplement and 1.28 with fish oil supplement). Calcium sparks in myocytes from rats which received saturated fat were significantly more prolonged than those from rats which received fish oil. (Lard = 105.4 +/- 18.9 ms; Fish oil = 43.5 +/- 4.7 ms: mean +/- s.e.m). The results for canola oil were intermediate (56.4 +/- 9.0 ms). The prolongation of the sparks in rats fed lard was primarily due to a higher proportion of sparks with long plateaus and/or slowed kinetics in this group. The frequency of sparks was not significantly different in cells from any group. We conclude that calcium handling mechanisms in rat atrial myocytes are affected by inclusion of different fats in the diet, correlated with changes in the cell membrane phospholipid composition, and speculate that this may underlie some of the antiarrhythmic properties of these dietary compounds.Bonny N. Honen, David A. Sain