MHD stability of JT-60SA operation scenarios driven by passing energetic particles for a hot Maxwellian model

We analyze the effects of the passing energetic particles on the resistive ballooning modes (RBM) and the energetic particle driven modes in JT-60SA plasma, which leads to the prediction of the stability in N-NBI heated plasma. The analysis is performed using the code FAR3d that solves the reduced MHD equations describing the linear evolution of the poloidal flux and the toroidal component of the vorticity in a full 3D system, coupled with equations of density and parallel velocity moments for the energetic particle (EP) species assuming an averaged Maxwellian EP distribution fitted to the slowing down distribution, including the effect of the acoustic modes. The simulations show the possible destabilization of a $3/2-4/2$ TAE with a frequency (f) of 115 kHz, a $6/4-7/4$ TAE with f = 98 kHz and a 6/4 or 7/4 BAE with f = 57 kHz in the ITER-like inductive scenario. If the energetic particle β increases, beta induced Alfven Eigenmodes (BAE), toroidal AEs (TAE) and elliptical AEs (EAE) are destabilized between the inner-middle plasma region, leading to the overlapping of AE of different toroidal families. If these instabilities coexist in the non-linear saturation phase the EP transport could be enhanced leading to a lower heating efficiency. For a hypothetical configuration based on the ITER-like inductive scenario but an center peaked EP profile, the EP β threshold increases and several BAEs are destabilized in the inner plasma region, indicating an improved AE stability with respect to the off-axis peaked EP profile. In addition, the analysis of a hypothetical JT-60SA scenario with a resonant q = 1 in the inner plasma region shows the destabilization of fishbones-like instabilities by the off-axis peaked EP profile. Also, the EPs have a stabilizing effect on the RBM, stronger as the population of EP with low energies (below 250 keV) increases at the plasma pedestal

DEC1 Modulates the Circadian Phase of Clock Gene Expression▿ †

DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear. Here we examined the effect of Dec1 overexpression or deficiency on circadian gene expression triggered with 50% serum. Overexpression of Dec1 delayed the phase of clock genes such as Dec1, Dec2, Per1, and Dbp that contain E boxes in their regulatory regions, whereas it had little effect on the circadian phase of Per2 and Cry1 carrying CACGTT E′ boxes. In contrast, Dec1 deficiency advanced the phase of the E-box-containing clock genes but not that of the E′-box-containing clock genes. Accordingly, DEC1 showed strong binding and transrepression on the E box, but not on the E′ box, in chromatin immunoprecipitation, electrophoretic mobility shift, and luciferase reporter assays. Dec1−/− mice showed behavioral rhythms with slightly but significantly longer circadian periods under conditions of constant darkness and faster reentrainment to a 6-h phase-advanced shift of a light-dark cycle. Knockdown of Dec2 with small interfering RNA advanced the phase of Dec1 and Dbp expression, and double knockdown of Dec1 and Dec2 had much stronger effects on the expression of the E-box-containing clock genes. These findings suggest that DEC1, along with DEC2, plays a role in the finer regulation and robustness of the molecular clock