DeWitt Wallace Library Annual Report 2016-2017

Summary of library and media services activities for 2016-201

DeWitt Wallace Library Annual Report 2015-2016

Summary of library and media services activities for 2015-201

DeWitt Wallace Library Annual Report 2017-2018

Summary of library and media services activities for 2017-201

Tumor Volume as an Alternative Response Measurement for Imatinib Treated GIST Patients

Background: Assessment of tumor size changes is crucial in clinical trials and patient care. We compared imatinib-induced volume changes of liver metastases (LM) from gastro-intestinal stromal tumors (GIST) to RECIST and Choi criteria and their association with overall survival (OS). Methods: LM from 84 GIST p

Ocean Measurements from Space in 2025

Seasat, launched by the US National Aeronautics and Space Administration (NASA) in 1977, was the first dedicated ocean-viewing satellite. Since then, in addition to NASA, the space agencies of Europe, France, Canada, Germany, India, Japan, and China have all launched ocean-viewing sensors or dedicated ocean-viewing satellites. Properties currently measured from space are sea surface temperature; topography (height); salinity; significant wave height and wave spectra; surface wind speed and vectors; ocean color; continental and sea ice extent, "flow, deformation, thickness; ocean mass; and to a lesser extent, surface currents. By 2025, one additional measurement may become available—total surface currents—but the largest foreseen improvements are increased spatial and temporal resolution and increased accuracy for all the currently measured properties

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy

Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

The major physiological function of milk is the transport of amino acids, carbohydrates, lipids and minerals to mammalian offspring. Caseins, the major milk proteins, are secreted in the form of a micelle consisting of protein and calcium-phosphate