59 research outputs found
Subcycle Quantum Electrodynamics
Besides their stunning physical properties which are unmatched in a classical
world, squeezed states of electromagnetic radiation bear advanced application
potentials in quantum information systems and precision metrology, including
gravitational wave detectors with unprecedented sensitivity. Since the first
experiments on such nonclassical light, quantum analysis has been based on
homodyning techniques and photon correlation measurements. These methods
require a well-defined carrier frequency and photons contained in a quantum
state need to be absorbed or amplified. They currently function in the visible
to near-infrared and microwave spectral ranges. Quantum nondemolition
experiments may be performed at the expense of excess fluctuations in another
quadrature. Here we generate mid-infrared time-locked patterns of squeezed
vacuum noise. After propagation through free space, the quantum fluctuations of
the electric field are studied in the time domain by electro-optic sampling
with few-femtosecond laser pulses. We directly compare the local noise
amplitude to the level of bare vacuum fluctuations. This nonlinear approach
operates off resonance without absorption or amplification of the field that is
investigated. Subcycle intervals with noise level significantly below the pure
quantum vacuum are found. Enhanced fluctuations in adjacent time segments
manifest generation of highly correlated quantum radiation as a consequence of
the uncertainty principle. Together with efforts in the far infrared, this work
opens a window to the elementary quantum dynamics of light and matter in an
energy range at the boundary between vacuum and thermal background conditions.Comment: 19 pages, 4 figure
Drug discovery in advanced prostate cancer: translating biology into therapy.
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the identification of novel drug targets and potent molecularly targeted therapeutics for this disease. In this article, we review recent advances in prostate cancer target identification for drug discovery and discuss their promise and associated challenges. We review the evolving therapeutic landscape of CRPC and discuss issues associated with precision medicine as well as challenges encountered with immunotherapy for this disease. Finally, we envision the future management of CRPC, highlighting the use of circulating biomarkers and modern clinical trial designs
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