4 research outputs found
Aerosol delivery from spacers in wheezy infants: a daily life study
The aims of this study were to assess and compare dose delivery and dose
variability of pressurized metered dose inhalers (pMDI)/spacers in wheezy
infants in daily life and to investigate factors influencing aerosol
delivery. In an open randomized crossover study in 25 wheezy infants aged
5-26 months, a metal spacer (Nebuchamber), a detergent coated (DC) and a
non-detergent coated (nonDC) plastic spacer (Babyhaler) were tested at
home for 7 days each. Budesonide (200 microg b.i.d) was administered via a
Nebuchamber or fluticasone (125 microg b.i.d) via a Babyhaler. Aerosol was
trapped in filters, positioned between the spacer and face mask.
Cooperation was scored on diary cards. Electrostatic charge (ESC) of the
spacers was measured. Evaluations of the administration technique were
made from video recordings. Median (range) dose delivery of the filters
expressed as per cent (%) of nominal dose, was 34% (3-59), 23% (1-49), and
41% (12-55) for the Nebuchamber, nonDC-Babyhaler, and DC-Babyhaler
respectively. Considerable dose variability was found, median (range)
within-subject dose variability, expressed as coefficient of variation,
for the Nebuchamber (49% (15-249)) was significantly higher when compared
with both nonDC- (36% (12-325)) and DC-Babyhalers (27% (10-122)), for
which dose variabilities were similar. Detergent coating was effective to
reduce electrostatic
A simple device to inject indicator gas for wash-out tests during mechanical ventilation
Objective: To evaluate a simple device which injects a constant fraction of indicator gas to the inspiratory mixture for performing multi-breath wash-out tests during controlled ventilation. Design: the technique in which the indicator gas is injected at the mouth of the patient (post-mix) is compared with the technique where the indicator gas is administered in the bellows of the ventilator (pre-mix). Setting: Surgical Intensive Care Unit of a University Hospital. Patients: 10 post-operative mechanically ventilated patients. Interventions: None. Measurements and results: 3 wash-out tests with the post-mix and 3 wash-out tests with the pre-mix method were performed within an hour on every patient. The calculated mean end expiratory lung volume (EEV) was 1.91±0.871 with the post-mix technique and 1.89±0.881 with the premix technique. There was a good agreement with a mean difference of -1.9±6.5% in the calculated EEV values by the two different techniques. Conclusion: The described injector is an affordable device, is easy to assemble and can be incorporated in most electronically regulated ventilators to perform multi-breath indicator gas wash-out tests for pulmonary monitoring at the bed side of ICU patients
Exhaled nitric oxide measurements with dynamic flow restriction in children aged 4-8 yrs
Fractional exhaled nitric oxide concentration (FENO) depends on exhalation
flow; however, children often are unable to perform controlled flow
procedures. Therefore, a device was developed for off-line FENO sampling,
with dynamic flow restriction (DFR). The authors compared off-line w