Neuropsychological data as assessed prior and six weeks after PTA.

*<p>p<0.05.</p>t<p>p<0.10.</p

Displayed are the numbers of patients who cognitively deteriorated or improved 6 weeks after intervention in 1, 2, 3, 4 or 5 cognitive domains.

<p>Adopting a conventional definition, cognitive change is assumed as significant if it exceeds one standard deviation in two or more domains.</p

Displayed are the numbers of patients who showed cognitive deficits prior to intervention in 1, 2, 3 or 4 cognitive domains (z-score<−1.0).

<p>Displayed are the numbers of patients who showed cognitive deficits prior to intervention in 1, 2, 3 or 4 cognitive domains (z-score<−1.0).</p

Number of patients who cognitively deteriorated, remained stable or improved after the intervention, separately displayed according to the incidence of new DWI lesions.

<p>Number of patients who cognitively deteriorated, remained stable or improved after the intervention, separately displayed according to the incidence of new DWI lesions.</p

Displayed are means and standard deviations of the difference values for all cognitive domains, correlation coefficients and the probability values.

<p>With exception of a significant association between semantic verbal fluency and lesion quantity, correlation analysis yielded no significant results.</p

Activated Protein C Resistance Does Not Increase Risk for Recurrent Stroke or Death in Stroke Patients

<div><p>Background</p><p>Activated protein C (APC) resistance is the most common inherited prothrombotic disorder. The role of APC resistance in ischemic stroke is controversially discussed.</p><p>Objectives</p><p>The aim of this single center follow up study was to investigate the effect of APC resistance on stroke recurrence and survival in stroke patients.</p><p>Patients/Methods</p><p>We retrospectively identified 966 patients who had had an ischemic stroke or transitory ischemic attack (TIA) and in whom laboratory tests for APC resistance had been conducted. These patients were contacted to determine the primary outcomes of recurrent ischemic stroke or death.</p><p>Results</p><p>A total of 858 patients with an average follow up time of 8.48 years were included. APC resistance did not influence cumulative incidence functions for stroke free and total survival. In multivariate analyses, crude and adjusted hazard ratios for recurrent stroke as well as for death where not significantly increased in patients with APC resistance. This also applies to the subgroups of young patients, patients with cryptogenic stroke and patients with atrial fibrillation.</p><p>Conclusion</p><p>APC-resistance is not a risk factor for subsequent stroke or death in patients with a first ischemic stroke or TIA. Testing for APC-resistance in stroke patients therefore cannot be routinely recommended.</p></div

Baseline data of considered patients.

<p>Baseline data of considered patients.</p

Multivariate analysis for all included patients.

<p>Multivariate analysis for all included patients.</p

Multivariate analysis for cryptogenic stroke patients.

<p>Multivariate analysis for cryptogenic stroke patients.</p

Multivariate analysis for atrial fibrillation patients.

<p>Multivariate analysis for atrial fibrillation patients.</p