Chronicles of Oklahoma

Article chronicles the media storm of misinformation that followed the shooting of three college student in Ardmore, Oklahoma. The students were parked on the side of the road when two plain clothes policemen pulled over to apprehend them for public urinating. The ensuing scuffle left two of the students dead, one of which was related to the Pascual Ortis Rubio, the president of the Republic of Mexico

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum.

BackgroundA vaccine that interrupts malaria transmission (VIMT) would be a valuable tool for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and mosquito stage antigens of the malaria parasite that induce immune responses targeted at disrupting parasite development in the mosquito. The standard Plasmodium falciparum membrane-feeding assay (SMFA) is used to assess transmission-blocking activity (TBA) of antibodies against candidate immunogens and of drugs targeting the mosquito stages. To develop its P. falciparum sporozoite (SPZ) products, Sanaria has industrialized the production of P. falciparum-infected Anopheles stephensi mosquitoes, incorporating quantitative analyses of oocyst and P. falciparum SPZ infections as part of the manufacturing process.MethodsThese capabilities were exploited to develop a robust, reliable, consistent SMFA that was used to assess 188 serum samples from animals immunized with the candidate vaccine immunogen, Pfs25, targeting P. falciparum mosquito stages. Seventy-four independent SMFAs were performed. Infection intensity (number of oocysts/mosquito) and infection prevalence (percentage of mosquitoes infected with oocysts) were compared between mosquitoes fed cultured gametocytes plus normal human O(+) serum (negative control), anti-Pfs25 polyclonal antisera (MRA39 or MRA38, at a final dilution in the blood meal of 1:54 as positive control), and test sera from animals immunized with Pfs25 (at a final dilution in the blood meal of 1:9).ResultsSMFA negative controls consistently yielded high infection intensity (mean = 46.1 oocysts/midgut, range of positives 3.7-135.6) and infection prevalence (mean = 94.2%, range 71.4-100.0) and in positive controls, infection intensity was reduced by 81.6% (anti-Pfs25 MRA39) and 97.0% (anti-Pfs25 MRA38), and infection prevalence was reduced by 12.9 and 63.5%, respectively. A range of TBAs was detected among the 188 test samples assayed in duplicate. Consistent administration of infectious gametocytes to mosquitoes within and between assays was achieved, and the TBA of anti-Pfs25 control antibodies was highly reproducible.ConclusionsThese results demonstrate a robust capacity to perform the SMFA in a medium-to-high throughput format, suitable for assessing large numbers of experimental samples of candidate antibodies or drugs

Triple and Quadruple Black Holes in the ASTRID Simulation at z∼2z \sim 2

We use the ASTRID cosmological hydrodynamic simulation to investigate the properties and evolution of triple and quadruple Massive Black Hole (MBH) systems at $z = 2-3$. Only a handful of MBH tuple systems have been detected to date. In ASTRID, we find $4\%$ of the $M_{\rm BH}>10^7\,M_\odot$ are in tuples with $\Delta r_{\rm max} < 200\,{\rm kpc}$. The tuple systems span a range of separations with the majority of the observable AGN systems at $\Delta r \sim 50-100$ kpc. They include some of the most massive BHs (up to $10^{10} \,M_\odot$) but with at least one of the components of $M_{\rm BH} \sim 10^7 \,M_\odot$. Tuples' host galaxies are typically massive with $M_* \sim 10^{10-11} \,M_\odot$. We find that $>10\%$ massive halos with $M_{\rm halo} > 10^{13} M_\odot$ host MBH tuples. Following the subsequent interactions between MBHs in tuples, we found that in $\sim 5\%$ of the triplets all three MBHs merge within a Gyr, and $15\%$ go through one merger. As a by-product of the complex multi-galaxy interaction of these systems, we also find that up to $\sim 5\%$ of tuples lead to runaway MBHs. In ASTRID, virtually all of the ultramassive black holes ($>10^{10} \,M_\odot$) have undergone a triple quasar phase while for BHs with $M_{\rm BH} \sim 10^9 \,M_\odot$ this fraction drops to $50\%$.Comment: 10 pages, 9 figures; comments welcom

Three-Body Kick to a Bright Quasar out of Its Galaxy During a Merger

The quasar HE0450-2958 was recently discovered to reside ~7kpc away from a galaxy that was likely disturbed by a recent merger. The lack of a massive spheroid of stars around the quasar raised the unlikely suggestion that it may have formed in a dark galaxy. Here we explain this discovery as a natural consequence of a dynamical kick imparted to the quasar as it interacted with a binary black hole system during a galaxy merger event. The typical stalling radius for a ~10^9 solar mass binary provides a kick of order the escape velocity of the stellar spheroid, bringing the quasar out to around the observed radius before it turns around. This is consistent with the observed low relative velocity between the quasar and the merger-remnant galaxy. The gas carried with the black hole throughout the three-body interaction fuels the quasar for the duration of its journey, ~2x10^7 years. Gravitational radiation recoil could not have produced the required kick.Comment: 5 pages, 2 figures, ApJ Letters, in pres

Matching Dynamics with Constraints

We study uncoordinated matching markets with additional local constraints that capture, e.g., restricted information, visibility, or externalities in markets. Each agent is a node in a fixed matching network and strives to be matched to another agent. Each agent has a complete preference list over all other agents it can be matched with. However, depending on the constraints and the current state of the game, not all possible partners are available for matching at all times. For correlated preferences, we propose and study a general class of hedonic coalition formation games that we call coalition formation games with constraints. This class includes and extends many recently studied variants of stable matching, such as locally stable matching, socially stable matching, or friendship matching. Perhaps surprisingly, we show that all these variants are encompassed in a class of "consistent" instances that always allow a polynomial improvement sequence to a stable state. In addition, we show that for consistent instances there always exists a polynomial sequence to every reachable state. Our characterization is tight in the sense that we provide exponential lower bounds when each of the requirements for consistency is violated. We also analyze matching with uncorrelated preferences, where we obtain a larger variety of results. While socially stable matching always allows a polynomial sequence to a stable state, for other classes different additional assumptions are sufficient to guarantee the same results. For the problem of reaching a given stable state, we show NP-hardness in almost all considered classes of matching games.Comment: Conference Version in WINE 201

The Grizzly, April 1, 2015

UC Stand Plans New Multi-Gender Fashion Show • Woodstock Receives Award • Experiences from Model UN • Ursinus Alum is Succeeding in the Business World • Women and Minorities on Wikipedia Examined • Opinion: The Challenges of Transferring to Ursinus • Tennis Teams Ace Early Slatehttps://digitalcommons.ursinus.edu/grizzlynews/1929/thumbnail.jp

The illusion of competency versus the desirability of expertise: Seeking a common standard for support professions in sport

In this paper we examine and challenge the competency-based models which currently dominate accreditation and development systems in sport support disciplines, largely the sciences and coaching. Through consideration of exemplar shortcomings, the limitations of competency-based systems are presented as failing to cater for the complexity of decision making and the need for proactive experimentation essential to effective practice. To provide a better fit with the challenges of the various disciplines in their work with performers, an alternative approach is presented which focuses on the promotion, evaluation and elaboration of expertise. Such an approach resonates with important characteristics of professions, whilst also providing for the essential ‘shades of grey’ inherent in work with human participants. Key differences between the approaches are considered through exemplars of evaluation processes. The expertise-focused method, although inherently more complex, is seen as offering a less ambiguous and more positive route, both through more accurate representation of essential professional competence and through facilitation of future growth in proficiency and evolution of expertise in practice. Examples from the literature are also presented, offering further support for the practicalities of this approach

Heavy Nuclei Synthesized in Gamma-Ray Burst Outflows as the Source of UHECRs

Recent measurements by the Pierre Auger Observatory suggest that the composition of ultra-high energy cosmic rays (UHECRs) becomes dominated by heavy nuclei at high energies. However, until now there has been no astrophysical motivation for considering a source highly enriched in heavy elements. Here we demonstrate that the outflows from Gamma-Ray Bursts (GRBs) may indeed be composed primarily of nuclei with masses A ~ 40-200, which are synthesized as hot material expands away from the central engine. In particular, if the jet is magnetically-dominated (rather than a thermally-driven fireball) its low entropy enables heavy elements to form efficiently. Adopting the millisecond proto-magnetar model for the GRB central engine, we show that heavy nuclei are both synthesized in proto-magnetar winds and can in principle be accelerated to energies >1e20 eV in the shocks or regions of magnetic reconnection that are responsible for powering the GRB. Similar results may apply to accretion-powered GRB models if the jet originates from a magnetized disk wind. Depending on the precise distribution of nuclei synthesized, we predict that the average primary mass may continue to increase beyond Fe group elements at the highest energies, possibly reaching the A ~ 90 (Zirconium), A ~ 130 (Tellurium), or even A ~ 195 (Platinum) peaks. Future measurements of the UHECR composition at energies >~ 1e20 eV can thus confirm or constrain our model and, potentially, probe the nature of GRB outflows. The longer attenuation length of ultra-heavy nuclei through the extragalactic background light greatly expands the volume of accesible sources and alleviates the energetic constraints on GRBs as the source of UHECRs.Comment: 10 pages, 3 figures, final version now accepted to MNRA