7 research outputs found
Synthesis and properties of aglyco transferrin
Iron is the most abundant metal in the universe and the fourth most common
element on earth. It is essential for all known life forms, with the possible exception of
a few micro-organisms. Depending on the ligand it is linked to, iron has access to a wide
range of redox potentials. It is involved in the redox reactions of the cell, especially in
those reactions implying molecular oxygen formation and the release of chemical energy
for use in the energy-requiring processes of life
Isoforms of transferrin in psoriasis patients abusing alcohol
The different isoforms of transferrin have been quantified by isoelectric
focusing in the sera of psoriasis patients with and without a history of
abusing alcohol. In both male and female psoriasis subjects abusing
alcohol, there were significant increases in the 2-sialylated forms by
comparison to the control subjects. Psoriasis patients who had no evidence
of alcohol abuse had similar profile for the isoforms of transferrin to
that of the controls. Other groups of patients with alcohol-induced tissue
damage, i.e. liver, brain or muscle, used as positive controls, similarly
showed significant increases in the 2-sialylated forms, by comparison to
controls. These results substantiate the current use of
carbohydrate-deficient transferrin as a sensitive marker of alcohol abuse,
particularly in subjects not drinking in excess of 60 g of ethanol/day but
showing alcohol-related psoriasis
Portable blood gas and electrolyte analyzer evaluated in a multiinstitutional study
A recently introduced blood gas/electrolyte analyzer (SenDx 100((R)),
renamed ABL70) intended for point-of-care, near-patient, or stat
laboratory use was evaluated simultaneously in four different institutions
and compared with three different laboratory bench analyzers with respect
to imprecision, inaccuracy (assessed by tonometry), and patient-sample
analyses. The analyzer is equipped with a sensor cassette and a reagent
cartridge for 50, 100, or 200 analyses and 100 or more traditional
quality-control measurements. One analysis requires 170 microL of whole
blood and takes <90 s. Statistically, the instrument performed somewhat
better (lower CVs) for PO2 and potassium and somewhat worse for pH, PCO2,
and ionized calcium than the respective comparison analyzers. However, the
overall performance (in terms of CV and accuracy) was satisfactory in
terms of clinical (e.g., CLIA '88) goals in all institutions. The mean
difference and the CV of that difference in some 400 patient-sample
comparisons were as follows: 0.010 (+/- 0.002%) for pH, -0.65 mmHg (+/-
4%) for PCO2, -0.49 mmHg (+/- 6%) for Po2, 0.44 mmol/L (+/- 1.2%) for
sodium, -0.013 mmol/L (+/- 2.9%) for potassium, -0.016 mmol/L (+/- 2.6%)
for ionized calcium, and -0.016 L/L (+/- 7. 1%) for the hematocrit. Its
acceptable analytical performance and ease of operation make the SenDx 100
suitable for the analysis of blood gases and electrolytes