Geology and palaeontology of a temporary exposure of the late Miocene Deurne sand in Antwerpen (N.Belgium)

A section of 6.10 m through the Deurne Sand Member (Diest Formation, Late Miocene) in Antwerpen (Antwerp) is described, which has been observed during the construction works of a new hospital building in the southern part of Deurne, and here called “Middelares Hospital Section” after that location. This temporary outcrop section can well be correlated with a similar one which was outcropping some 35 years ago, and was located at some 1.5 km to the NE. It was studied in detail by De Meuter et al. (1967), who called it the “Borgerhout-Rivierenhof VII B.R.” section. Since that section was the most relevant of the previously described sections in the Deurne Sand Member, it is here suggested to designate that section as stratotype for the member. Part of the fossil content, mainly the macrofossils (Brachiopoda, Mollusca, Ostracoda, Thoracica, Pisces, Reptilia and Mammalia) is listed. Two species of Terebratulidae (Pliothyrina sowerbyana (Nyst, 1843) and Terebratula cf. ampulla Brocchi, 1814) were recognized. The Mollusca are represented by 24 taxa, of which the Pectinidae are the most common. One undescribed ostracod taxon (Thaerocythere sp.) is restricted to the Deurne Sands and can be considered a stratigraphic marker for this member. Fossil Lepadomorpha are recorded for the first time from the Belgian Late Miocene. The Squalus sp. from the Deurne Sands closely resembles the Squalus sp. from the Gramian of Denmark. Preliminary data about a fairly complete skeleton of a Mysticete whale, probably belonging to the genus Plesiocetus Van Beneden (in Van Beneden & Gervais, 1880) are given. The recovered specimen of Ziphirostrum is characteristic of Z. laevigatum and is probably different from Z. belgicus. The molluscan fauna seems to point to a shallow environment with swiftly changing currents, moving sand bars or megaripples subjected to tidal currents. Palaeoclimatological data cannot be deducted from the fossils encountered

Real-time monitoring of drug-laboratory test interactions with an automated decision support application

Background-aim: The lack of knowledge of the presence of Drug-Laboratory Test Interactions (DLTIs) can cause misinterpretation of laboratory test results and delayed or erroneous diagnosis with extra healthcare costs and even harm to patients. There are over 50.000 physiological and/or analytical drug-test interactions described. In this pilot study, an automated decision support application was used to detect drug laboratory test interactions in real-time. Methods: In this multicentre study, 34 clinical rules about DLTI were programmed and validated in an automated decision support application (Gaston, Medecs B.V.). The DLTIs were described in a validated database from the Dutch Society for Clinical Chemistry. The application is able to generate a DLTI-based advisory text based on predefined aberrant laboratory test results and medication data from individual patients and present this alert text to the laboratory specialist in the laboratory information system. The software application was successfully connected and installed in one hospital laboratory in 2018 with two other hospitals to follow in 2019. Generated real-time DLTI alerts were collected and monitored during 4 weeks. Results: A mean of 45 DLTI alerts were generated per day. Twenty-one out of 34 clinical rules were generated at least once in this period. The most frequently reported interactions were magnesium - proton pump inhibitors (14%), creatine kinase – statins (13%) and potassium - ACE-inhibitors (13%). Most DLTI alerts were from the internal medicine department (43%), cardiology department (22%) and the emergency department (10%). Conclusions: In this study, an automated decision support application was implemented to facilitate signalling the presence of drug laboratory test interactions. A mean of 45 DLTI alerts per day were generated in this study. The clinical relevance of the alerts for laboratory specialists and physicians will be examined