Risk and Resilience of Somali Children in the Context of Climate Change, Famine, and Conflict

Climate change is an existential threat to all of humanity. Its impact on the children of Somalia provides insights into the severity of risks posed by climate change to current and future generations. Globally, there has been a continuous increase in mean annual temperatures since 1991 and scientists anticipate an increase of up to 4.3 degrees Celsius by the end of the century. Concomitantly, Somalia has experienced a decrease in annual rainfall, resulting in recurrent droughts. According to the UN’s emergency aid coordination office, these droughts have grown in frequency and intensity over the past three decades, fueling increased frequency of famine and contributing to internal conflict and civil war. In this article, the impact of climate change on children, exemplified by the plight of Somali children, is viewed through the lens of cumulative adversity and related consequences of poverty on malnutrition, illness, disruptions of family systems, and displacement, with a diaspora around the globe. The paper promotes a multi-systems resilience framework that guides strategies for addressing the complex, cascading crises that accompany climate change, exploring the construct of resilience from the individual/interpersonal level through family systems and communities, including a reframing of the Somali diaspora. The paper concludes with a series of global transnational policy recommendations based on children’s rights, the promotion of resilience, and approaching climate change from a child sensitive perspective, encouraging youth engagement and leadership, along with peace-building

Long-Term Impact of Radiation on the Stem Cell and Oligodendrocyte Precursors in the Brain

Background. The cellular basis of long term radiation damage in the brain is not fully understood. Methods and Findings. We administered a dose of 25Gy to adult rat brains while shielding the olfactory bulbs. Quantitative analyses were serially performed on different brain regions over 15 months. Our data reveal an immediate and permanent suppression of SVZ proliferation and neurogenesis. The olfactory bulb demonstrates a transient but remarkable SVZ-independent ability for compensation and maintenance of the calretinin interneuron population. The oligodendrocyte compartment exhibits a complex pattern of limited proliferation of NG2 progenitors but steady loss of the oligodendroglial antigen O4. As of nine months post radiation, diffuse demyelination starts in all irradiated brains. Counts of capillary segments and length demonstrate significant loss one day post radiation but swift and persistent recovery of the vasculature up to 15 months post XRT. MRI imaging confirms loss of volume of the corpus callosum and early signs of demyelination at 12 months. Ultrastructural analysis demonstrates progressive degradation of myelin sheaths with axonal preservation. Areas of focal necrosis appear beyond 15 months and are preceded by widespread demyelination. Human white matter specimens obtained post-radiation confirm early loss of oligodendrocyte progenitors and delayed onset of myelin sheath fragmentation with preserved capillaries. Conclusions. This study demonstrates that long term radiation injury is associated with irreversible damage to the neural stem cell compartment in the rodent SVZ and loss of oligodendrocyte precursor cells in both rodent and human brain. Delayed onset demyelination precedes focal necrosis and is likely due to the loss of oligodendrocyte precursor

MRI of Late Microstructural and Metabolic Alterations in Radiation-Induced Brain Injuries

Purpose: To evaluate the late effects of radiation-induced damages in the rat brain by means of in vivo multipara- metric MRI. Materials and Methods: The right hemibrains of seven Sprague-Dawley rats were irradiated with a highly colli- mated 6 MV photon beam at a single dose of approximately 28 Gy. Diffusion tensor imaging (DTI), proton MR spectros- copy (1H-MRS), T2-weighted imaging, and T1-weighted im- aging were performed to the same animals 12 months after radiation treatment. Results: Compared with the contralateral side, a signifi- cantly higher percentage decrease in fractional anisotropy was observed in the ipsilateral fimbria of hippocampus (29%) than the external capsule (8%) in DTI, indicating the selective vulnerability of fimbria to radiation treatment. Furthermore, in 1H-MRS, significantly higher choline, glu- tamate, lactate, and taurine peaks by 24%, 25%, 87%, and 58%, respectively, were observed relative to creatine in the ipsilateral brain. Postmortem histology confirmed these white matter degradations as well as glial fibrillary acidic protein and glutamine synthetase immunoreactivity in- crease in the ipsilateral brain. Conclusion: The microstructural and metabolic changes in late radiation-induced brain injuries were documented in vivo. These multiparametric MRI measurements may help understand the white matter changes and neurotoxicity upon radiation treatment in a single setting. © 2009.link_to_subscribed_fulltex