Integrating visual and tactile information in the perirhinal cortex

By virtue of its widespread afferent projections, perirhinal cortex is thought to bind polymodal information into abstract object-level representations. Consistent with this proposal, deficits in cross-modal integration have been reported after perirhinal lesions in nonhuman primates. It is therefore surprising that imaging studies of humans have not observed perirhinal activation during visual–tactile object matching. Critically, however, these studies did not differentiate between congruent and incongruent trials. This is important because successful integration can only occur when polymodal information indicates a single object (congruent) rather than different objects (incongruent). We scanned neurologically intact individuals using functional magnetic resonance imaging (fMRI) while they matched shapes. We found higher perirhinal activation bilaterally for cross-modal (visual–tactile) than unimodal (visual–visual or tactile–tactile) matching, but only when visual and tactile attributes were congruent. Our results demonstrate that the human perirhinal cortex is involved in cross-modal, visual–tactile, integration and, thus, indicate a functional homology between human and monkey perirhinal cortices

Network Lasso: Clustering and Optimization in Large Graphs

Convex optimization is an essential tool for modern data analysis, as it provides a framework to formulate and solve many problems in machine learning and data mining. However, general convex optimization solvers do not scale well, and scalable solvers are often specialized to only work on a narrow class of problems. Therefore, there is a need for simple, scalable algorithms that can solve many common optimization problems. In this paper, we introduce the \emph{network lasso}, a generalization of the group lasso to a network setting that allows for simultaneous clustering and optimization on graphs. We develop an algorithm based on the Alternating Direction Method of Multipliers (ADMM) to solve this problem in a distributed and scalable manner, which allows for guaranteed global convergence even on large graphs. We also examine a non-convex extension of this approach. We then demonstrate that many types of problems can be expressed in our framework. We focus on three in particular - binary classification, predicting housing prices, and event detection in time series data - comparing the network lasso to baseline approaches and showing that it is both a fast and accurate method of solving large optimization problems

Enhancing creative problem solving and creative self-efficacy: a preliminary study

The ability to improve creative problem solving (CPS) is considered to be an important resource in a variety of fields such as education (see Murdock, 2003) and business (see Thompson, 2003). Previous research suggests that interventions aimed at training people to improve their CPS skills can be effective, however it is not always clear what tools are being used and it is sometimes difficult to untangle the effect the different tools are having (see Vernon, Hocking, & Tyler, 2016, for a review). This study therefore aimed to utilise an empirically- based creativity toolkit in an 8 week training program aimed at enhancing students' CPS skills. The intervention group was comprised of 33 psychology students who signed up to undertake 8 weeks of CPS training and the control group (n = 9) were matched for contact time, undertaking 8 weeks of cognitive psychology lectures instead. In week 1 (Time 1) and week 8 (Time 2) all participants were assessed using two Unusual Uses Tasks (UUT) and a Creative Problem Solving (CPS) task and were also asked to fill out measures of creative self-efficacy. Analyses revealed that whilst the control group showed no improvement on any of the measures from Time 1 to Time 2, the intervention group showed a significant increase in both their creative self-efficacy and also their levels of creativity on both the UUT and CPS tasks. Whilst a follow- up study utilising a larger control group is ideally needed, these preliminary findings nonetheless support the use of this empirically based creativity toolkit for enhancing creativity problem solving skills

The Potential For UK Portfolio Investors To Finance Sustainable Tropical Forestry

Environmental Economics and Policy, Resource /Energy Economics and Policy,

The Adelaide VHF radar: Capabilities and future plans

The VHF radar at Buckland Park, South Australia commenced operation in January, 1984. The radar is located adjacent to the 2-MHz ionospheric radar. The routine method for measuring horizontal wind velocity is the space antenna technique (SA) while the Doppler technique is used to measure vertical velocities. It is possible to swing the transmitting beam in the east-west plane, allowing Doppler measurements of the EW wind component

Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross

An F broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits. Thirty-six additional QTL were identified when the assumption that QTL were fixed in the grandparent lines was relaxed. QTL with large effects on the lengths of the tarsometatarsus, tibia and femur, and the weights of the tibia and femur were identified on GGA4 between 217 and 249 cM. Six QTL for skeletal traits were identified that did not co-locate with genome wide significant QTL for body weight and two body weight QTL did not coincide with skeletal trait QTL. Significant evidence of imprinting was found in ten of the QTL and QTL x sex interactions were identified for 22 traits. Six alleles from the broiler line for weight- and size-related skeletal QTL were positive. Negative alleles for bone quality traits such as tibial dyschondroplasia, leg bowing and tibia twisting generally originated from the layer line suggesting that the allele inherited from the broiler is more protective than the allele originating from the layer

Topological constraints on spiral wave dynamics in spherical geometries with inhomogeneous excitability

We analyze the way topological constraints and inhomogeneity in the excitability influence the dynamics of spiral waves on spheres and punctured spheres of excitable media. We generalize the definition of an index such that it characterizes not only each spiral but also each hole in punctured, oriented, compact, two-dimensional differentiable manifolds and show that the sum of the indices is conserved and zero. We also show that heterogeneity and geometry are responsible for the formation of various spiral wave attractors, in particular, pairs of spirals in which one spiral acts as a source and a second as a sink -- the latter similar to an antispiral. The results provide a basis for the analysis of the propagation of waves in heterogeneous excitable media in physical and biological systems.Comment: 5 pages, 6 Figures, major revisions, accepted for publication in Phys. Rev.

Innovating for improved healthcare: Sociotechnical and innovation systems perspectives and lessons from the NHS

Healthcare systems with limited resources face rising demand pressures. Healthcare decision-makers increasingly recognise the potential of innovation to help respond to this challenge and to support high-quality care. However, comprehensive and actionable evidence on how to realise this potential is lacking. We adopt sociotechnical systems and innovation systems theoretical perspectives to examine conditions that can support and sustain innovating healthcare systems. We use primary data focussing on England (with 670 contributions over time) and triangulate findings against globally-relevant literature. We discuss the complexity of factors influencing an innovating healthcare system’s ability to support the development and uptake of innovations and share practical learning about changes in policy, culture, and behaviour that could support system improvement. Three themes are examined in detail: skills, capabilities, and leadership; motivations and accountabilities; and collaboration and coordination. We also contribute to advancing applications of sociotechnical systems thinking to major societal transformation challenges

Hydrodynamic theory of de-wetting

A prototypical problem in the study of wetting phenomena is that of a solid plunging into or being withdrawn from a liquid bath. In the latter, de-wetting case, a critical speed exists above which a stationary contact line is no longer sustainable and a liquid film is being deposited on the solid. Demonstrating this behavior to be a hydrodynamic instability close to the contact line, we provide the first theoretical explanation of a classical prediction due to Derjaguin and Levi: instability occurs when the outer, static meniscus approaches the shape corresponding to a perfectly wetting fluid

Comparison of Na Lidar and Meteor Radar Wind Measurements at Starfire Optical Range, NM, USA

Simultaneous wind measurements in the mesopause region at Starfire Optical Range near Albuquerque, NM with Na wind/temperature lidar and meteor radar have been performed and compared. 20 nights of hourly data recorded with these two instruments at two layers around 86 and 93 km altitude are compared for both zonal and meridional wind components. The mean values are found to have no statistically significant differences. The correlation coefficients vary between 0.63 and 0.70, indicating that the two sets of measurements are broadly consistent. When comparing the averaged variations over the night, the two measurements are highly correlated, with correlation coefficients varying from 0.84 to 0.95. It indicates that the strong tidal variation is well captured by both instruments. Differences are however significant at individual hours, which are believed to be mainly due to the fact that the meteor radar wind is an average over the entire sky while the lidar measures wind within a volume about 100 m in diameter