Method of calculation of electrical properties of materials based on the results of quantum-chemical calculations

The work is devoted to a literary analysis of methods for interpreting the results of quantum-chemical calculations of the electronic structure. The concept of calculating the density of electronic states on the basis of the results obtained by the Hartree-Fock method is given. The structural scheme of the software based on the constructed concept is presented

Expression of somatic-stem transition genes and macrophage-associated genes in breast tumor

In a study of breast cancer of 68 patients before and after neoadjuvant chemotherapy, overexpression in the residual tumor of 14/16 genes of the somato-stem transition was shown in patients with metastases that subsequently developed. This confirms our hypothesis about the important role of activation of the ability to somato-stem transition for tumor metastasis, which occurs under the influence of neoadjuvant chemotherapy. A new prognostic factor has been established, which makes it possible to predict the occurrence of hematogenous metastases with a sensitivity of 69%, a specificity of 94%, and a diagnostic accuracy of 82%

Электропривод и электрооборудование механизма подъема экскаватора ЭШ 20/90

Произведен расчёт и выбор силового оборудования для электропривода механизма подъема одноковшового экскаватора ЭШ 20/90. Исследованы статические и динамические характеристики двухконтурной системы автоматического регулирования электропривода экскаватора.The calculation and choice of power equipment for the electric drive of the lifting mechanism of the one-bucket excavator ES 20/90 is made. The static and dynamic characteristics of a two-circuit automatic control system for the electric drive of an excavator are studied

Extrakorporale Membranoxygenierung mit dem DeltaStream-System bei experimentell induziertem akutem Lungenversagen

Acute Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) belong to the most frequent indications for admission to an intensive care unit. Both ARDS and ALI are mainly characterized by a ventilation-perfusion mismatch resulting in intrapulmonary shunting and hence in hypoxemia and hypercapnia. Improved understanding of the pathogenesis has led to advances in the treatment of ARDS/ALI. However, standard supportive care including a protective ventilatory strategy with low tidal volumes is frequently not successful in improving gas exchange in severe cases of ARDS/ALI. Therefore, veno-venous extracorporeal membrane oxygenation (ECMO) may be a life-saving therapy ensuring a sufficient gas exchange. However, the clinical use of ECMO is limited due to the size of traditionally used centrifugal pumps and associated risks of adverse events. In contrast, the DeltaStream-system represents a miniaturized extracorporal circuit consisting of a diagonal blood pump and characterized by a significantly reduced foreign surface area and a decreased extracorporeal volume. We thus hypothesized that the DeltaStream-system may reduce contact activation of the blood resulting in less blood trauma. In addition, the aim of the present study was to test safety and efficacy of the DeltaStream-system for extracorporeal lung assist in pigs with experimental induced ALI. After the induction of experimental ALI in 6 pigs by repetitive lung lavages, veno-venous ECMO was started and performed for 6 hours. Extracorporeal blood flow was set to equal 30% of cardiac output, and gas flow with a FiO2 of 1,0 was set to equal blood flow. Maintaining an ACT (Activated Clotting Time) of 123±23 s, no circulatory impairment or thrombus formation was revealed during ECMO. Furthermore, neither free plasma Hb nor fibrinogen concentrations increased significantly during ECMO. Pigs showed no cardiocirculatory dysfunction during the observation period. Gas transfer across the extracorporeal oxygenators allowed an efficacious CO2 removal in all animals. However, only in 2 animals a marked increase in PaO2 was notable. In conclusion, the use of the DeltaStream-system in our study was not associated with major blood damage, thrombus formation or hemodynamic impairment. Thus, the DeltaStream-system may be a promising new tool in the treatment of ARDS/ALI by ECMO

Extrakorporale Membranoxygenierung mit dem DeltaStream-System bei experimentell induziertem akutem Lungenversagen

Acute Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) belong to the most frequent indications for admission to an intensive care unit. Both ARDS and ALI are mainly characterized by a ventilation-perfusion mismatch resulting in intrapulmonary shunting and hence in hypoxemia and hypercapnia. Improved understanding of the pathogenesis has led to advances in the treatment of ARDS/ALI. However, standard supportive care including a protective ventilatory strategy with low tidal volumes is frequently not successful in improving gas exchange in severe cases of ARDS/ALI. Therefore, veno-venous extracorporeal membrane oxygenation (ECMO) may be a life-saving therapy ensuring a sufficient gas exchange. However, the clinical use of ECMO is limited due to the size of traditionally used centrifugal pumps and associated risks of adverse events. In contrast, the DeltaStream-system represents a miniaturized extracorporal circuit consisting of a diagonal blood pump and characterized by a significantly reduced foreign surface area and a decreased extracorporeal volume. We thus hypothesized that the DeltaStream-system may reduce contact activation of the blood resulting in less blood trauma. In addition, the aim of the present study was to test safety and efficacy of the DeltaStream-system for extracorporeal lung assist in pigs with experimental induced ALI. After the induction of experimental ALI in 6 pigs by repetitive lung lavages, veno-venous ECMO was started and performed for 6 hours. Extracorporeal blood flow was set to equal 30% of cardiac output, and gas flow with a FiO2 of 1,0 was set to equal blood flow. Maintaining an ACT (Activated Clotting Time) of 123±23 s, no circulatory impairment or thrombus formation was revealed during ECMO. Furthermore, neither free plasma Hb nor fibrinogen concentrations increased significantly during ECMO. Pigs showed no cardiocirculatory dysfunction during the observation period. Gas transfer across the extracorporeal oxygenators allowed an efficacious CO2 removal in all animals. However, only in 2 animals a marked increase in PaO2 was notable. In conclusion, the use of the DeltaStream-system in our study was not associated with major blood damage, thrombus formation or hemodynamic impairment. Thus, the DeltaStream-system may be a promising new tool in the treatment of ARDS/ALI by ECMO

Boy running through the snow, England

Cataloguer's title.The Rorke Family Photograph Collection contains 301 black and white and 28 colour photographs of the Rorke Family of Carbonear, Newfoundland, as well as the Forward and Bemister families from that area who are linked to it by marriage. Although spanning from the 1840s-1970s, most photos are from 1900-45, showing family events, homes and Newfoundland and Labrador locations. There is also an album of photos taken while James Rorke attended the Leys School in Cambridge, England

Estimating Respiratory Rate in Post-Anesthesia Care Unit Patients Using Infrared Thermography: An Observational Study

The post-anesthesia care unit (PACU) is the central hub for recovery after surgery, especially when the surgery is performed under general anesthesia. Aside from clinical aspects, respiratory impairment is one of the major causes of morbidity and affected recovery in the PACU and should therefore be monitored. In previous studies, infrared thermography was applied to assess the breathing rate (BR) of healthy volunteers. Here, the transferability of published methods for postoperative patients in the PACU was examined. Video recordings of 28 patients were acquired using a long-wave infrared camera, and analyzed offline. For validation purposes, BRs derived from body surface electrocardiography were measured simultaneously. In general, a close agreement between the two techniques (r = 0.607, p = 0.002 upon arrival, and r = 0.849, p < 0.001 upon discharge from the PACU) was obtained. In conclusion, the algorithm was demonstrated to be feasible and reliable under these challenging conditions