Molecular and Ionised Gas Motions in the Compact HII region G29.96-0.02

We present a new observation of the compact HII region, G29.96-0.02, that allows us to compare the velocity structure in the ionised gas and surrounding molecular gas directly. This allows us to remove most of the remaining ambiguity about the nature of this source. In particular, the comparison of the velocity structure present in the 4S-3P HeI lines with that found in the 1-0 S(1) of molecular hydrogern convincingly rules out a bow shock as being important to the kinematics of this source. Our new observation therefore agrees with our previous conclusion, drawn from a velocity resolved HI Br gamma map, that most of the velocity structure in G29.96-0.02 can largely be explained as a result of a champagne flow model. We also find that the best simple model must invoke a powerful stellar wind to evacuate the `head' of the cometary HII region of ionised gas. However, residual differences between model and data tend to indicate that no single simple model can adequately explain all the observed features.Comment: 10 pages, 4 postscript figures. To be published in MNRA

An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy.

An ultra scale-down method is described to determine the response of cells to recovery by dead-end (batch) centrifugation under commercially defined manufacturing conditions. The key variables studied are the cell suspension hold time prior to centrifugation, the relative centrifugal force (RCF), time of centrifugation, cell pellet resuspension velocities, and number of resuspension passes. The cell critical quality attributes studied are the cell membrane integrity and the presence of selected surface markers. Greater hold times and higher RCF values for longer spin times all led to the increased loss of cell membrane integrity. However, this loss was found to occur during intense cell resuspension rather than the preceding centrifugation stage. Controlled resuspension at low stress conditions below a possible critical stress point led to essentially complete cell recovery even at conditions of extreme centrifugation (e.g., RCF of 10000 g for 30 mins) and long (~2 h) holding times before centrifugation. The susceptibility to cell loss during resuspension under conditions of high stress depended on cell type and the age of cells before centrifugation and the level of matrix crosslinking within the cell pellet as determined by the presence of detachment enzymes or possibly the nature of the resuspension medium. Changes in cell surface markers were significant in some cases but to a lower extent than loss of cell membrane integrity. Biotechnol. Bioeng. 2015;112: 997-1011. © 2014 Wiley Periodicals, Inc

Infrared Helium-Hydrogen Line Ratios as a Measure of Stellar Effective Temperature

We have observed a large sample of compact planetary nebulae in the near-infrared to determine how the 2^1P-2^1S HeI line at 2.058um varies as a function of stellar effective temperature, Teff. The ratio of this line with HI Br g at 2.166um has often been used as a measure of the highest Teff present in a stellar cluster, and hence on whether there is a cut-off in the stellar initial mass function at high masses. However, recent photoionisation modelling has revealed that the behaviour of this line is more complex than previously anticipated. Our work shows that in most aspects the photoionisation models are correct. In particular, we confirm the weakening of the 2^1P-2^1S as Teff increases beyond 40000K. However, in many cases the model underpredicts the observed ratio when we consider the detailed physical conditions in the individual planetary nebulae. Furthermore, there is evidence that there is still significant 2^1P-2^1S HeI line emission even in the planetary nebulae with very hot (Teff>100000K) central stars. It is clear from our work that this ratio cannot be considered as a reliable measure of effective temperature on its own.Comment: 24 pages 11 figures (in 62 separate postscript files) Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Near Infrared Spectra of Compact Planetary Nebulae

This paper continues our study of the behaviour of near infrared helium recombination lines in planetary nebula. We find that the 1.7007um 4^3D-3^3P HeI line is a good measure of the HeI recombination rate, since it varies smoothly with the effective temperature of the central star. We were unable to reproduce the observed data using detailed photoionisation models at both low and high effective temperatures, but plausible explanations for the difference exist for both. We therefore conclude that this line could be used as an indicator of the effective temperature in obscured nebula. We also characterised the nature of the molecular hydrogen emission present in a smaller subset of our sample. The results are consistent with previous data indicating that ultraviolet excitation rather than shocks is the main cause of the molecular hydrogen emission in planetary nebulae.Comment: Accepted for publication in MNRA

IR Dust Bubbles: Probing the Detailed Structure and Young Massive Stellar Populations of Galactic HII Regions

We present an analysis of wind-blown, parsec-sized, mid-infrared bubbles and associated star-formation using GLIMPSE/IRAC, MIPSGAL/MIPS and MAGPIS/VLA surveys. Three bubbles from the Churchwell et al. (2006) catalog were selected. The relative distribution of the ionized gas (based on 20 cm emission), PAH emission (based on 8 um, 5.8 um and lack of 4.5 um emission) and hot dust (24 um emission) are compared. At the center of each bubble there is a region containing ionized gas and hot dust, surrounded by PAHs. We identify the likely source(s) of the stellar wind and ionizing flux producing each bubble based upon SED fitting to numerical hot stellar photosphere models. Candidate YSOs are also identified using SED fitting, including several sites of possible triggered star formation.Comment: 37 pages, 17 figure

On partial order semantics for SAT/SMT-based symbolic encodings of weak memory concurrency

Concurrent systems are notoriously difficult to analyze, and technological advances such as weak memory architectures greatly compound this problem. This has renewed interest in partial order semantics as a theoretical foundation for formal verification techniques. Among these, symbolic techniques have been shown to be particularly effective at finding concurrency-related bugs because they can leverage highly optimized decision procedures such as SAT/SMT solvers. This paper gives new fundamental results on partial order semantics for SAT/SMT-based symbolic encodings of weak memory concurrency. In particular, we give the theoretical basis for a decision procedure that can handle a fragment of concurrent programs endowed with least fixed point operators. In addition, we show that a certain partial order semantics of relaxed sequential consistency is equivalent to the conjunction of three extensively studied weak memory axioms by Alglave et al. An important consequence of this equivalence is an asymptotically smaller symbolic encoding for bounded model checking which has only a quadratic number of partial order constraints compared to the state-of-the-art cubic-size encoding.Comment: 15 pages, 3 figure

Molecular cloud distance determination from deep NIR survey extinction measurements

Using near infrared UKIDSS Galactic Plane Survey data, we make extinction measurements to individual stars along the same line of sight as molecular clouds. Using an existing 3D extinction map of the inner Galaxy, that provides line of sight specific extinction-distance relationships, we convert the measured extinction of molecular clouds to a corresponding distance. These distances are derived independently from kinematic methods, typically used to derive distances to molecular clouds, and as such they have no near/far ambiguity. The near/far distance ambiguity has been resolved for 27 clouds and distances have been derived to 20 clouds. The results are found to be in good agreement with kinematic measurements to molecular clouds where the ambiguity has already been resolved, using HI self-absorption techniques.Comment: MNRAS accepted: 07/05/201

Velocity dependence of friction and Kramers relaxation rates

We study the influence of the velocity dependence of friction on the escape of a Brownian particle from the deep potential well ($E_{b} \gg k_{B}T$, $E_{b}$ is the barrier height, $k_{B}$ is the Boltzmann constant, $T$ is the bath temperature). The bath-induced relaxation is treated within the Rayleigh model (a heavy particle of mass $M$ in the bath of light particles of mass $m\ll M$) up to the terms of the order of $O(\lambda^{4})$, $\lambda^{2}=m/M\ll1$. The term $\sim 1$ is equivalent to the Fokker-Planck dissipative operator, and the term $\sim \lambda^{2}$ is responsible for the velocity dependence of friction. As expected, the correction to the Kramers escape rate in the overdamped limit is proportional to $\lambda^{2}$ and is small. The corresponding correction in the underdamped limit is proportional to $\lambda^{2}E_{b}/(k_{B}T)$ and is not necessarily small. We thus suggest that the effects due to the velocity-dependent friction may be of considerable importance in determining the rate of escape of an under- and moderately damped Brownian particle from a deep potential well, while they are of minor importance for an overdamped particle