Humanising language testing

Test-takers' voices in relation to high-stakes language tests have received growing attention in recent years. While the perspectives of this stakeholder group can be utilised to improve test quality, test-taking experience, and test impact, we argue that this goal needs to be achieved by considering a fundamental shift in our conceptualisation of language tests based on test-takers' experiential and perceptual data. This is a shift towards humanising language testing in a globalised world which has witnessed growing expansion, commercialisation, and potential dehumanising of high-stakes tests such as IELTS (International English Language Testing System). Drawing on data from two larger studies, we illustrate the call for humanising the test in seven areas including test purpose, test policy, test-taking experience, test administration, test-taker background, test content and task, and feedback on test performance. Although humanisation has accumulated specific meanings and contentions in the past few decades, test-takers' call for a friendly, responsive, and closer-to-life test and a less stressful test-taking experience may appear more legitimate than controversial in a globalised world

Velocity-resolved high-J CO emission from massive star-forming clumps

(Abridged) Context. Massive star formation is associated with energetic processes, which result in significant gas cooling via far-infrared (IR) lines. Velocity-resolved observations can constrain the kinematics of the gas, allowing the identification of the physical mechanisms responsible for gas heating. Aims. Our aim is to quantify far-infrared CO line emission toward high-mass star-forming regions, identify the high-velocity gas component associated with outflows, and estimate the physical conditions required for the excitation of the observed lines. Methods. Velocity-resolved SOFIA/GREAT spectra of 13 high-mass star forming clumps of various luminosities and evolutionary stages are studied using CO 11-10 and 16-15 lines. Results. All targets show strong high-J CO emission in the far-IR, characterized by broad line wings associated with outflows, thereby significantly increasing the sample of sources with velocity-resolved high-J CO spectra. The contribution of the emission in the line wings does not correlate with the envelope mass or evolutionary stage. Gas rotational temperatures cover a narrow range of 120-220 K for the line wings. The non-LTE radiative transfer models indicate gas densities of 1e5-1e7 cm-3 and N(CO) of 1e17- 1e18 cm-2, similar to physical conditions in deeply-embedded low- and high-mass protostars. The velocity-integrated CO line fluxes correlate with the bolometric luminosity over 7 orders of magnitude including data on the low-mass protostars, suggesting similar processes are responsible for the high-J CO excitation over a significant range of physical scales. Conclusions. Velocity-resolved line profiles allow the detection of outflows toward massive star-forming clumps spanning a broad range of evolutionary stages. The lack of clear evolutionary trends suggest that mass accretion and ejection prevail during the entire lifetime of star-forming clumps.Comment: 21 pages, 19 figures, accepted to A&

The Higgs Sector of the Minimal 3 3 1 Model Revisited

The mass spectrum and the eigenstates of the Higgs sector of the minimal 3 3 1 model are revisited in detail. There are discrepancies between our results and previous results by another author.Comment: 20 pages, latex, two figures. One note and one reference are adde

System for Performing Single Query Searches of Heterogeneous and Dispersed Databases

The present invention is a distributed computer system of heterogeneous databases joined in an information grid and configured with an Application Programming Interface hardware which includes a search engine component for performing user-structured queries on multiple heterogeneous databases in real time. This invention reduces overhead associated with the impedance mismatch that commonly occurs in heterogeneous database queries

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6 J mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity

The 331 model with right-handed neutrinos

We explore some more consequences of the $SU(3)_L\otimes U(1)_N$ electroweak model with right-handed neutrinos. By introducing the $Z - Z'$ mixing angle $\phi$, the {\it exact} physical eigenstates for neutral gauge bosons are obtained. Because of the mixing, there is a modification to the $Z^1$ coupling proportional to $\sin\phi$. The data from the $Z$-decay allows us to fix the limit for $\phi$ as $-0.0021 \leq \phi \leq 0.000132$. >From the neutrino neutral current scatterings, we estimate a bound for the new neutral gauge boson $Z^2$ mass in the range 300 GeV, and from symmetry-breaking hierarchy a bound for the new charged and neutral (non-Hermitian) gauge bosons $Y^{\pm}, X^o$ are obtained.Comment: Slight changes in section 5, Latex, 16 page

Targeted sequencing from cerebrospinal fluid for rapid identification of drug-resistant tuberculous meningitis

Mortality from tuberculous meningitis (TBM) remains around 30%, with most deaths occurring within 2 months of starting treatment. Mortality from drug-resistant strains is higher still, making early detection of drug resistance (DR) essential. Targeted next-generation sequencing (tNGS) produces high read depths, allowing the detection of DR-associated alleles with low frequencies. We applied Deeplex Myc-TB-a tNGS assay-to cerebrospinal fluid (CSF) samples from 72 adults with microbiologically confirmed TBM and compared its genomic drug susceptibility predictions to a composite reference standard of phenotypic susceptibility testing (pDST) and whole genome sequencing, as well as to clinical outcomes. Deeplex detected Mycobacterium tuberculosis complex DNA in 24/72 (33.3%) CSF samples and generated full DR reports for 22/24 (91.7%). The read depth generated by Deeplex correlated with semi-quantitative results from MTB/RIF Xpert. Alleles with <20% frequency were seen at canonical loci associated with first-line DR. Disregarding these low-frequency alleles, Deeplex had 100% concordance with the composite reference standard for all drugs except pyrazinamide and streptomycin. Three patients had positive CSF cultures after 30 days of treatment; reference tests and Deeplex identified isoniazid resistance in two, and Deeplex alone identified low-frequency rifampin resistance alleles in one. Five patients died, of whom one had pDST-identified pyrazinamide resistance. tNGS on CSF can rapidly and accurately detect drug-resistant TBM, but its application is limited to those with higher bacterial loads. In those with lower bacterial burdens, alternative approaches need to be developed for both diagnosis and resistance detection

Using multiple lines of evidence to assess the risk of ecosystem collapse

Effective ecosystem risk assessment relies on a conceptual understanding of ecosystem dynamics and the synthesis of multiple lines of evidence. Risk assessment protocols and ecosystem models integrate limited observational data with threat scenarios, making them valuable tools for monitoring ecosystem status and diagnosing key mechanisms of decline to be addressed by management. We applied the IUCN Red List of Ecosystems criteria to quantify the risk of collapse of the Meso-American Reef, a unique ecosystem containing the second longest barrier reef in the world. We collated a wide array of empirical data (field and remotely sensed), and used a stochastic ecosystem model to backcast past ecosystem dynamics, as well as forecast future ecosystem dynamics under 11 scenarios of threat. The ecosystem is at high risk from mass bleaching in the coming decades, with compounding effects of ocean acidification, hurricanes, pollution and fishing. The overall status of the ecosystem is Critically Endangered (plausibly Vulnerable to Critically Endangered), with notable differences among Red List criteria and data types in detecting the most severe symptoms of risk. Our case study provides a template for assessing risks to coral reefs and for further application of ecosystem models in risk assessment.This work was supported by the Australian Research Council LP 130100435 and a Veski Inspiring Women Fellowship to E.N

Mapping for engagement: setting up a community based participatory research project to reach underserved communities at risk for Hepatitis C in Ho Chi Minh City, Vietnam

Background: Approximately 1. 07 million people in Vietnam are infected with hepatitis C virus (HCV). To address this epidemic, the South East Asian Research Collaborative in Hepatitis (SEARCH) launched a 600-patient cohort study and two clinical trials, both investigating shortened treatment strategies for chronic HCV infection with direct-acting antiviral drugs. We conducted ethnographic research with a subset of trial participants and found that the majority were aware of HCV infection and its implications and were motivated to seek treatment. However, people who inject drugs (PWID), and other groups at risk for HCV were under-represented, although injecting drug use is associated with high rates of HCV. Material and Methods: We designed a community-based participatory research (CBPR) study to engage in dialogues surrounding HCV and other community-prioritized health issues with underserved groups at risk for HCV in Ho Chi Minh City. The project consists of three phases: situation analysis, CBPR implementation, and dissemination. In this paper, we describe the results of the first phase (i.e., the situation analysis) in which we conducted desk research and organized stakeholder mapping meetings with representatives from local non-government and community-based organizations where we used participatory research methods to identify and analyze key stakeholders working with underserved populations. Results: Twenty six institutions or groups working with the key underserved populations were identified. Insights about the challenges and dynamics of underserved communities were also gathered. Two working groups made up of representatives from the NGO and CBO level were formed. Discussion: Using the information provided by local key stakeholders to shape the project has helped us to build solid relationships, give the groups a sense of ownership from the early stages, and made the project more context specific. These steps are not only important preliminary steps for participatory studies but also for other research that takes place within the communities