1,690 research outputs found
Role of Percutaneous Cardiopulmonary Support (PCPS) in Patients with Unstable Hemodynamics During the Peri-Coronary-Intervention Period
7 Role of Percutaneous Cardiopulmonary Support (PCPS) in Patients with Unstable Hemodynamics During the Peri-Coronary-Intervention Period
7 Role of Percutaneous Cardiopulmonary Support (PCPS) in Patients with Unstable Hemodynamics During the Peri-Coronary-Intervention Period
Triflumizole
In the title compound {systematic name: 4-chloro-N-[1-(1H-imidazol-1-yl)-2-propoxyethylÂidene]-2-(trifluoroÂmethÂyl)aniline}, C15H15ClF3N3O, the dihedral angle between the aniline and imidazole ring planes is 81.80 (4)°. In the crystal structure, weak interÂmolecular C—H⋯X (X = N, O or F) hydrogen bonds and C—H⋯π interÂactions help to consolidate the packing
Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress. This study investigated the regulation of Nrf2 by G{alpha}12 and G{alpha}13. A deficiency of G{alpha}12, but not of G{alpha}13, enhanced Nrf2 activity and target gene transactivation in embryo fibroblasts. In mice, G{alpha}12 knockout activated Nrf2 and thereby facilitated heme catabolism to bilirubin and its glucuronosyl conjugations. An oligonucleotide microarray demonstrated the transactivation of Nrf2 target genes by G{alpha}12 gene knockout. G{alpha}12 deficiency reduced Jun N-terminal protein kinase (JNK)-dependent Nrf2 ubiquitination required for proteasomal degradation, and so did G{alpha}13 deficiency. The absence of G{alpha}12, but not of G{alpha}13, increased protein kinase C {delta} (PKC {delta}) activation and the PKC {delta}-mediated serine phosphorylation of Nrf2. G{alpha}13 gene knockout or knockdown abrogated the Nrf2 phosphorylation induced by G{alpha}12 deficiency, suggesting that relief from G{alpha}12 repression leads to the G{alpha}13-mediated activation of Nrf2. Constitutive activation of G{alpha}13 promoted Nrf2 activity and target gene induction via Rho-mediated PKC {delta} activation, corroborating positive regulation by G{alpha}13. In summary, G{alpha}12 and G{alpha}13 transmit a JNK-dependent signal for Nrf2 ubiquitination, whereas G{alpha}13 regulates Rho-PKC {delta}-mediated Nrf2 phosphorylation, which is negatively balanced by G{alpha}12
Diclomezine: 6-(3,5-dichloro-4-methylÂphenÂyl)pyridazin-3(2H)-one
In the title compound, C11H8Cl2N2O, the benzene and pyridazine rings are tilted by 8.6 (1)° relative to each other. In the crystal, pairs of interÂmolecular N—H⋯O hydrogen bonds form centrosymmetric dimers. π–π contacts with centroid–centroid distances of 3.698 (2) and 3.751 (1) Å and halogen–halogen interÂactions [3.379 (1) Å] also stabilize the structure
N-(Pyridin-2-ylmethÂyl)pyridin-2-amine
The title compound, C11H11N3, crystallizes with two molÂecules (A and B) in the asymmetric unit. The geometries of both molÂecules are very similar, with the exception of the torsion angles of the inter-ring chains; the values for C—N—C—C are 67.4 (5) and −69.3 (5)° for molÂecules A and B, respectively. The dihedral angles between the pyridyl ring planes are 84.0 (2) and 83.2 (2)° for molÂecules A and B, respectively. In the crystal, weak interÂmolecular N—H⋯N hydrogen bonds and C—H⋯π interÂactions contribute to the stabilization of the packing
Bis[μ-N-(pyridin-2-ylmethÂyl)pyridin-2-amine-κ2 N:N′]disilver(I) bis(trifluoroÂmethaneÂsulfonate)
In the binuclear title compound, [Ag2(C11H11N3)2](CF3O3S)2, the complex cation is centrosymmetric, with the unique Ag+ cation coordinated by two pyridine N atoms from two symmetry-related N-(pyridin-2-ylmethÂyl)pyridin-2-amine ligands in a geometry slightly distorted from linear [N—Ag—N 161.02 (7)°]. This set-up leads to the formation of a 14-membered cyclic dimer. The two pyridine rings coordinated to the Ag+ cation are tilted by 80.19 (7)° with respect to each other. InterÂmolecular N—H⋯O hydrogen-bonding interÂactions between the cyclic dimer and the anion exist. A two-dimensional network parallel to the ac plane is constructed by three weak Ag⋯(O,N) interÂactions as well as an F⋯F contact of 2.890 (4) Å
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