Differences of Upper Airway Morphology According to Obesity: Study with Cephalometry and Dynamic MD-CT

ObjectivesWe investigated difference of parameters of polysomnography, cephalometry and dynamic multi-detector computerized tomography (MD-CT) in wake and sleep states according to obesity.MethodsWe evaluated 93 patients who underwent polysomnography and cephalometry. MD-CT was performed in 68 of these 93 patients. Fifty-nine and 34 patients were classified as obese and non-obese, with obesity defined as BMI ≥25. Cephalometry results were analyzed for 12 variables. Using the MD-CT, we evaluated dynamic upper airway morphology in wake and sleep states and divided the upper airway into four parts named as high retropalatal (HRP), low retropalatal (LRP), high retroglossal (HRG), and low retroglossal (LRG). A minimal cross sectional area (mCSA) and collapsibility index (CI) were calculated for each airway level.ResultsDiastolic blood pressure (P=0.0005), neck circumference (P<0.0001), and apnea-hypopnea index (P<0.0001) were statistically significantly different between the obese and non-obese group. Among 12 cephalometric variables, there was a significant difference in only the distance from mandibular plane to hyoid bone (P=0.003). There was statistical difference in CI of HRG and LRG in sleep state (P=0.0449, 0.0281) but no difference in mCSA in wake and sleep states.ConclusionThe obese group had more severe sleep apnea than the non-obese group. We believe that the increased severity of apnea in the obese group may be have been due to increased collapsibility of the upper airway rather than decreased size of the upper airway

Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion

Objective: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. Methods: NET and NE expression levels were examined by western blot and enzyme-linked immunosorbent assay, respectively. Trophoblast invasion activity, depending on NE-NET regulation, was determined by NET-small interfering RNA (siRNA) and NET transfection into the human extravillous trophoblast cells with or without NE treatment and invasion rates were analyzed by zymography and an invasion assay. Results: NET mRNA was expressed at a low level in pre-eclamptic placentas compared with normal placentas and NE concentration in maternal plasma increased significantly in pre-eclamptic women compared to normal pregnant women (p<0.05). NET gene upregulation and NE treatment stimulated trophoblast cell invasion up to 2.5-fold (p<0.05) by stimulating matrix metalloproteinase-9 activity via the phosphoinositol-3-kinase/AKT signaling pathway, whereas NET-siRNA with NE treatment reduced invasion rates. Conclusion: NET expression is reduced by inadequate regulation of NE levels during placental development. This suggests that a complementary balance between NET and NE regulates trophoblast cell invasion activities during placental development

Hybrid XML Data Model Architecture for Efficient Document Management

XML has been known as a document standard in representation and exchange of data on the Internet, and is also used as a standard language for the search and reuse of scattered documents on the Internet. The issues related to XML are how to model data on effective and efficient management of semi-structured data and how to actually store the modeled data when implementing a XML contents management system. Previous researches on XML have limitations in (1) reproduction of XML documents from the stored data, (2) retrieval of XML sub-graph from search, (3) supporting only top-down search, not full-search, and (4) dependency of data structure on XML documents. The purpose of this paper is to present a hybrid XML data model architecture for the storage and search of XML document data. By representing both data and structure views of XML documents, this new XML data model technique overcomes the limitations of previous researches on data model for XML documents as well as the existing database systems such as relational and object-oriented data model

Analysis of Offset Antennas in Radio Telescopes

We present an analysis on the performance of two popular dual offset antennas design, i.e. the offset Cassegrain and Gregorian reflector antennas. In our study, we have adopted the design parameters for the Cassegrain configuration used in the Atacama Large Milimeter Array (ALMA) project. Modifications on the original parameters are made so as to meet the design requirement of the offset configurations. To reduce spillover loss, we have adjusted the angle between the axis of the primary reflector and that of the sub-reflector to 0.20o. The results obtained from the physical optics computation show that the amplitude at the main lobe of the Gregorian configuration is approximately 74.02 dB, while that of the Cassegrain configuration is approximately 74 dB. The maximum (relative) side lobe level, SLLdB for the Cassegrain and Gregorian configurations are found as -3.67 dB and -3.69 dB respectively. Although the magnitude of the main lobe for both configurations is comparable, the Gregorian antenna gives relatively lower SLLdB. In other words, the Gregorian configuration performs relatively better than its Cassegrainian counterpart

OMAE2004-51081 HULL FORMS FOR ICEBREAKING TANKERS

ABSTRACT The optimum design for an icebreaking tanker will depend on the trade route and the cargo delivery requirements. For example, the hull shape of a ship that spends almost all of its time operating in heavy ice can be optimized for low speed icebreaking conditions. In contrast, a ship that spends a small portion of its time in light ice that has been previously broken and the rest of its time in open water can be optimized for different requirements. The challenge for the designer is complicated by the observation that many ship design features that enhance powering performance in ice are detrimental to open water performance. This paper presents predictions of ship resistance in pack ice, level ice and open water for four tanker designs, which include a conventional hull with no modification for ice at all and three designs proposed for operation in Arctic ice conditions. The predictions of ship performance are based on model experiments carried out in Canada and Korea. The resistance of the four hulls in open water, two concentrations of pack ice and two level ice thicknesses are compared and discussed. Information of this sort is essential for developing the optimum ship design for a particular shipping route, given known profiles of open water, pack ice and level ice