The Vietnam Osteoporosis Study: Rationale and design.

ObjectivesOsteoporosis and fracture impose a significant health care burden on the contemporary populations in developing countries. The Vietnam Osteoporosis Study (VOS) sought to assess the burden of osteoporosis and its comorbidities in men and women.MethodsThe study was designed as a population-based family investigation in which families were randomly recruited from Ho Chi Minh City, Vietnam. Individuals were assessed for bone health, including bone mineral density (BMD) and body composition and trabecular and cortical bone properties by pQCT (peripheral quantitative computed tomography). Fasting blood samples were obtained for the analysis of plasma glucose, glycosylated hemoglobin, and bone turnover markers. Genomic DNA extraction from whole blood samples for further genetic and genomic analyses.ResultsWe have recruited more than 4157 individuals from 817 families. The average age of participants was 51, with approximately 45% of the individuals aged 50 years and older. Approximately 3% of participants were obese (body mass index ≥ 30 kg/m2), and 21% were overweight. Notably, 11% of participants aged 40 years and older were diabetic. Among those aged 50 years and older, approximately 14% of women and 5% of men had osteoporosis (i.e., femoral neck BMD T-scores ≤ -2.5). There were modest correlations between volumetric BMD and areal BMD.ConclusionsVOS is a major bone research project in Vietnam aimed at comprehensively documenting the burden osteoporosis, its co-occurrence of chronic diseases, and their underlying etiologies. The Study will make important contributions to the literature of bone health worldwide

Association between carotid intima-media thickness and bone mineral density: A cross-sectional study in Vietnamese men and women aged 50 years and older

© 2019 Author(s). Objectives The association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background. Design and setting Cross-sectional study in Ho Chi Minh City, Vietnam. Participants The study involved 1460 individuals (559 men) aged 50 years and older (average age 59 years) who were randomly recruited from the community. Outcome measures BMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model. Results In unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R 2 =0.005; p=0.015) but not in women (partial R 2 =0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women. Conclusions In Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women

Quantification of the relative contribution of estrogen to bone mineral density in men and women

Background: The study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women. Methods. This was a cross-sectional study which involved 200 men and 415 women aged 18 to 89 years. BMD at the lumbar spine (LS) and femoral neck (FN) was measured by DXA. Serum levels of E2 and TT were measured by electrochemiluminescence immunoassays. The association between E2, TT, and BMD was analyzed by the multiple linear regression model, adjusting for age and BMI. The contribution of each hormone to the variation in BMD was quantified by the bootstrap method. Results: In women, higher serum levels of E2, but not TT, were significantly associated with greater BMD at the FN (P = 0.001) and LS (P < 0.0001). In men, higher serum levels of E2 were independently associated with greater FNBMD (P = 0.008) and LSBMD (P = 0.086). In the multiple linear regression model, age, body weight and E2 accounted for 50-55% variance in FNBMD, and 25% (in men) and 48% (in women) variance in LSBMD. Variation in E2 accounted for 2.5% (95% CI 0.4 - 7.8%) and 11.3% (95% CI 8.1 - 15.3%) variation in FNBMD in men and women, respectively. Moreover, E2 contributed 1.2% (95% CI 0.1 - 5.8%) and 11.7% (95% CI 8.5 - 15.9%) variation in LSBMD in men and women, respectively. Conclusions: Estrogen is more important than testosterone in the determination of age-related bone mineral density men and women of Vietnamese background. However, the relative contributions of estrogen to bone mineral density in men are likely modest. © 2013 Ho-Pham et al.; licensee BioMed Central Ltd

E-cigarette use, nicotine addiction and intention to quit among adolescent smokers in Hong Kong

Conference Theme: Tobacco and Non-Communicable DiseasesPoster Discussion 28. E-cigarettes: Evidence and Analysis: no. PD-924-20BACKGROUND: Although some studies have shown beneficial effects of e-cigarettes on smoking cessation in adults, less is known about e-cigarette use and its association with nicotine addiction and intention to quit smoking in adolescents. DESIGN/METHODS: A school-based smoking survey was conducted on 45857 secondary 1-6 (US Grade 7-12) students (response rate 96%) from 75 randomly selected secondary schools in Hong Kong in 2013/13. A total of 1768 (3.9%) current smokers (occasional or daily) were included in the present analysis. E-cigarette use in the past 30 days, intention to quit smoking (cigarette), and quit attempts in the past 12 months were recorded. Smoking …published_or_final_versio

E-cigarette use was associated with the intention to smoke in Chinese adolescents

Conference Theme: Tobacco and Non-Communicable DiseasesPoster Discussion 28. E-cigarettes: Evidence and Analysis: no. PD-923-20BACKGROUND: E-cigarette use arguably could reduce cigarette smoking and the intention to smoke, although such studies are few, especially in adolescents. We investigated the association between e-cigarette use and the intention to smoke in Chinese adolescent smokers and never-smokers. DESIGN/METHODS: A total of 45857 secondary 1-6 (US Grade 7-12) students (response rate 96%) from 75 randomly selected schools completed an anonymous questionnaire in 2012/13 in Hong Kong. Students were classified as never-smokers, experimenters (smoked just a few puffs), ex-smokers and current smokers (occasional or daily smoking). E-cigarette use in the past 30 days was …published_or_final_versio

Electronic cigarette use and its association with smoking in Hong Kong Chinese adolescents

BACKGROUND: Electronic cigarettes (e-cigarettes) are increasingly used in adolescents with unknown impacts on conventional cigarette smoking. We examined the associations of e-cigarette use with smoking intention, nicotine addiction and smoking cessation in Chinese adolescents. METHODS: A total of 45,128 students (age 14.6±1.9; boys 51.4%) from 75 randomly selected schools in Hong Kong reported e-cigarette use (in the past 30days), conventional cigarette use and socio-demographic characteristics in an anonymous questionnaire survey. Adjusted odds ratios (AORs) of intention to smoke, morning smoking urge, intention to quit and quit attempts; and beta-coefficient (β) of cigarette consumption per day were calculated in relation to e-cigarette use. RESULTS: E-cigarette use was associated with intention to smoke with an AOR (95% CI) of 1.74 (1.30-2.31) in all students, 2.18 (1.12-4.23) in never and 2.79 (2.05-3.79) in ever smokers (non-significant interaction by smoking status). The associations were also significant in experimental and former smokers but not in current smokers. In current smokers, e-cigarette use was significantly associated with heavier smoking (β 2.54, 95% CI 1.28-3.81) and morning smoking urge (AOR 2.54, 95% CI 1.50-3.11), and non-significantly associated with lower quit intention (0.76, 0.52-1.09) and attempts (0.80, 0.56-1.23). CONCLUSIONS: E-cigarette use was associated with smoking intention in never, experimental and former smokers in Hong Kong Chinese adolescents. In current smokers, e-cigarette use was associated with nicotine addiction but not quit intention and attempts. Prospective studies with detailed measurements on e-cigarette use are warranted for further studies. Copyright © 2015 Elsevier Ltd. All rights reserved.postprin

E-cigarette use was associated with respiratory symptoms among Chinese adolescents in Hong Kong

Conference Theme: Tobacco and Non-Communicable DiseasesOral Presentation - 05. Innovative Ways for Achieving Tobacco Free Generations: no. OP-229-20BACKGROUND: Adverse effects of e-cigarette use were not clear. Some studies have found harmful effects on respiratory function (respiratory flow resistance and impedance) in adult smokers. We assessed the association between cigarette use and respiratory symptoms in adolescents. DESIGN/METHODS: A school-based smoking survey was conducted on 45857 secondary 1-6 (US Grade 7-12) students (response rate 96%) from 75 randomly selected secondary schools in Hong Kong in 2012/13 …published_or_final_versio

Secondhand smoke from multiple sources, thirdhand smoke and respiratory symptoms in Hong Kong adolescents

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Electronic Cigarette Use and Respiratory Symptoms in Chinese Adolescents in Hong Kong

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Trends in breast cancer incidence in Ho Chi Minh City 1996-2015: A registry-based study.

The burden of breast cancer in Vietnam has not been documented. This study sought to estimate the incidence of breast cancer in Ho Chi Minh City, the largest economic center of Vietnam, from 1996 to 2015. This was a population-based study using the Ho Chi Minh City Cancer Registry as a source of data (coverage period: 1996-2015). The Registry adopted the International Classification of Diseases for Oncology, 3rd Edition for the classification of primary sites and morphology, and guidelines from the International Agency for Research on Cancer and the International Association of Cancer Registries. Using the population statistics from census data of Ho Chi Minh City, the point incidence of breast cancer for 5-year period was estimated. Based on the national population, we calculated the age-standardized rate (ASR) of breast cancer between 1996 and 2015. Overall 14,222 new cases of breast cancer (13,948 women, or 98%) had been registered during the 1996-2015 period; among whom, just over half (52%) were in the 2nd stage and 26% in the 3rd and 4th stages. In women, the median age at diagnosis was 50 years and there was a slight increase over time. The ASR of breast cancer during the 2011-2015 period was 107.4 cases per 100,000 women, representing an increase of 70% compared to the rate during the 1996-2000 period. In men, there was also a significant increase in the ASR: from 1.13 during the 1996-2001 period to 2.32 per 100,000 men during the 2011-2015 period. These very first data from Vietnam suggest that although the incidence of breast cancer in Vietnam remains relatively low, it has increased over time