1,588 research outputs found
Colonoscopic surveillance and screening for familial colorectal cancer: experience of a regional registry
Conference Theme: Challenges to specialists in the 21st centurypublished_or_final_versio
Genetic-guided screening programme for familial adenomatous polyposis: result of a regional registry
Conference Theme: Challenges to specialists in the 21st centurypublished_or_final_versio
Microsatellite instability and mismatch repair gene mutations are common in young colorectal cancer patients in Hong Kong
Conference Theme: Challenges to Specialists in the 21st centurypublished_or_final_versio
Effects of Qigong Exercise on Fatigue, Anxiety, and Depressive Symptoms of Patients with Chronic Fatigue Syndrome-Like Illness: A Randomized Controlled Trial
published_or_final_versio
Promotor hypermethylation of the CpG Islands of human Ras Association Domain Family 1A gene (RASSF1A) in adenocarcinoma of lung in Hong Kong Chinese - a comparison between smokers and non-smokers
published_or_final_versio
Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor receptor and BAX in gastric carcinomas in Hong Kong Chinese
Conference Theme: Challenges to specialists in the 21st centurypublished_or_final_versio
A randomized controlled trial of qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome
BACKGROUND: Chronic fatigue is common in the general population. Complementary therapies are often used by patients with chronic fatigue or chronic fatigue syndrome to manage their symptoms. PURPOSE: This study aimed to assess the effect of a 4-month qigong intervention program among patients with chronic fatigue or chronic fatigue syndrome. METHODS: Sixty-four participants were randomly assigned to either an intervention group or a wait list control group. Outcome measures included fatigue symptoms, physical functioning, mental functioning, and telomerase activity. RESULTS: Fatigue symptoms and mental functioning were significantly improved in the qigong group compared to controls. Telomerase activity increased in the qigong group from 0.102 to 0.178 arbitrary units (p < 0.05). The change was statistically significant when compared to the control group (p < 0.05). CONCLUSION: Qigong exercise may be used as an alternative and complementary therapy or rehabilitative program for chronic fatigue and chronic fatigue syndrome.published_or_final_versio
Unique pattern of infections in chronic granulomatous disease – The Asian experience
Conference Theme: Inflammatory Basis of Perinatal and Childhood DiseasesSymposium 40: InfectionBackground: Chronic granulomatous disease (CGD) is a phagocytic disorder
caused by defective NADPH oxidase activity. Affected individuals are susceptible
to bacterial infections, mycosis and hyperinflammatory complications. Variations
in the epidemiology of infectious diseases across geographical regions can lead
to distinct clinical phenotypes.
Objective: To identify the unique clinical characteristics of a large cohort of CGD
patients in China and Southeast Asia referred for genetic studies from 2003 to
2012.
Methods: 53 patients with genetically-confirmed CGD were included and their
clinical features were analyzed. CYBB and CYBA mutations were studied by
Sanger sequencing, and NCF1 ‘GT’ deletion hotspot mutation was studied on
genomic DNA by GeneScan.
Results: 44 patients with X-CGD had CYBB mutations (missense[n=16];
nonsense[n=8]; deletion[n=9]; insertion[n=2]; intron mutation[n=9]). Nine
patient had AR-CGD (CYBA[n=5]; NCF1 75_76delGT[n=4]). The median age at
presentation and diagnosis was higher in AR-CGD (7m and 66m) compared with
X-CGD (3m and 22m). The commonest presentations were pneumonia (58%), skin and perianal abscess (49%), lymphadenitis (42%) and recurrent diarrhea (30%).
Aspergillosis and salmonellosis occurred at a frequency similar to published
studies (13% and 19% respectively), but the commonest infection was BCG (43%)
and 11% had disseminated BCG. 21% of patients had tuberculosis. Fulminant
melioidosis and Chromobacterium violaceum infections occurred in 3 patients
and two of their male siblings. Hyperinflammatory conditions included polyarthritis
(n=3) and pulmonary granuloma (n=2). Death was recorded in 8 patients (15%).
Conclusion: Melioidosis and C. violaceum indigenous to Southeast Asia can cause
life-threatening infections in CGD patients. The high incidence of mycobacterial
infections is associated with universal BCG vaccination and endemicity of
tuberculosis. Such observations emphasize the role of respiratory burst as an
immune defense mechanism against these pathogens. These infections are
seldom reported in Caucasian cohorts, illustrating the importance of regional
collaborative studies to facilitate pattern recognition and early diagnosis of
primary immunodeficiencies.published_or_final_versio
Indicators for assessing the quality of refractive error care
Significance: Quality refractive error care is essential for reducing vision impairment. Quality indicators and standardized approaches for assessing the quality of refractive error care need to be established. Purpose: This study aimed to develop a set of indicators for assessing the quality of refractive error care and test their applicability in a real-world setting using unannounced standardized patients (USPs). Methods: Patient outcomes and three quality of refractive error care (Q.REC) indicators (1, optimally prescribed spectacles; 2, adequately prescribed spectacles; 3, vector dioptric distance) were developed using existing literature, refraction training standards, and consulting educators. Twenty-one USPs with various refractive errors were trained to visit optical stores across Vietnam to have a refraction, observe techniques, and order spectacles. Spectacles were assessed against each Q.REC indicator and tested for associations with vision and comfort. Results: Overall, 44.1% (184/417) of spectacles provided good vision and comfort. Of the spectacles that met Q.REC indicators 1 and 2, 62.5 and 54.9%, respectively, provided both good vision and comfort. Optimally prescribed spectacles (indicator 1) were significantly more likely to provide good vision and comfort independently compared with spectacles that did not meet any indicator (good vision: 94.6 vs. 85.0%, P =.01; comfortable: 66.1 vs. 36.3%, P <.01). Adequately prescribed spectacles (indicator 2) were more likely to provide good comfort compared with spectacles not meeting any indicator (57.7 vs. 36.3%, P <.01); however, vision outcomes were not significantly different (85.9 vs. 85.0%, P =.90). Good vision was associated with a lower mean vector dioptric distance (P <.01) but not with comfort (P =.52). Conclusions: The optimally prescribed spectacles indicator is a promising approach for assessing the quality of refractive error care without additional assessments of vision and comfort. Using USPs is a practical approach and could be used as a standardized method for evaluating the quality of refractive error care
Shape-induced force fields in optical trapping
Advances in optical tweezers, coupled with the proliferation of two-photon polymerization systems, mean that it is now becoming routine to fabricate and trap non-spherical particles. The shaping of both light beams and particles allows fine control over the flow of momentum from the optical to mechanical regimes. However, understanding and predicting the behaviour of such systems is highly complex in comparison with the traditional optically trapped microsphere. In this Article, we present a conceptually new and simple approach based on the nature of the optical force density. We illustrate the method through the design and fabrication of a shaped particle capable of acting as a passive force clamp, and we demonstrate its use as an optically trapped probe for imaging surface topography. Further applications of the design rules highlighted here may lead to new sensors for probing biomolecule mechanics, as well as to the development of optically actuated micromachines
- …