903 research outputs found

    The critical importance of the Soviet role in Vietnam's economic reforms - fact or fallacy?

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    At its Sixth National Party Congress in December 1986, a drastic leadership change occurred in the Communist Party of Vietnam (CPV). Truong Chinh, Pham Van Dong and Le Due Tho all stepped down from top Party positions, accepting most of the blame for the country's appalling socio-economic condition. The new leadership that replaced them, led by Nguyen Van Linh, is now faced with the task of reforming the country's ailing economy. To do this, it has embarked on a wide-ranging series of economic reforms. As these reforms gain momentum in the second half of the 1980s, it has seen the concomitant rise of a new class of leaders in the Politburo labelled as "reformers", the most prominent of whom are the country's new leader, Nguyen Van Linh, and the State Planning Commission Chairman. Vo Van Kiet

    Gastric Schwannoma

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    Schwannomas, also known as neurinomas or neurilemmomas, are generally benign, slow-growing neoplasms originating in any nerve that has a Schwann cell sheath. These neoplasms are rare among the spindle cell mesenchymal tumors of the gastrointestinal tract, but develop most commonly in the stomach representing 0.2% of all gastric tumors. We present the case of a 57-year-old female patient with a large schwannoma in the stomach that was palpable in the abdomen. She underwent subtotal gastrectomy under suspicion of gastrointestinal stromal tumor (GIST), but post-operative histopathological and immunohistochemical findings showed a fascicular arrangement of spindle cell with pallisading nuclei, and positive for S-100 protein with negative smooth muscle actin (SMA). These results confirmed schwannoma as the diagnosis

    A 9-year-old Korean girl with Fontaine progeroid syndrome: a case report with further phenotypical delineation and description of clinical course during long-term follow-up

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    Background Gorlin–Chaudhry–Moss syndrome (GCMS) and Fontaine–Farriaux syndrome (FFS) are extremely rare genetic disorders that share similar clinical manifestations. Because a de novo missense mutation of the solute carrier family 25 member 24 (SLC25A24) gene was suggested to be the common genetic basis of both syndromes, it has been proposed recently that they be integrated into a single disorder under the name of Fontaine progeroid syndrome (FPS). Case presentation A 9-year-old Korean girl presented with typical clinical features of FPS. She had generalized loose skin with decreased subcutaneous fat, skin wrinkling on the forehead and limbs, skull deformities and a peculiar facial appearance with microphthalmia and midface hypoplasia, anomalies of the digits and nails, a large umbilical hernia and a nearly normal developmental outcome. She exhibited prenatal and postnatal growth retardation together with short stature, and records showed that her height and weight were invariably under − 2.0 SD from birth to the age of 10 years. SLC25A24 analysis revealed a heterozygous mutation reported previously, NM_013386:c.650G > A, p.[Arg217His]. After screening her family for the identified mutation, she was confirmed as being a de novo case of FPS caused by an SLC25A24 mutation. Conclusion We describe a Korean girl with typical clinical findings of FPS and a de novo mutation in SLC25A24, as well as 10 years of clinical follow-up, including growth and developmental achievements.This study was supported by grant no. 05–2018-0010 from the SNUH Research Fund. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript

    Distinguishing Six Edible Berries Based on Metabolic Pathway and Bioactivity Correlations by Non-targeted Metabolite Profiling

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    Berries have been used as valuable sources of polyphenols for human health; however, injudicious uses of berries are widespread without regard to the specific metabolite constituent of each berry. We classified 6 different edible berries (honeyberry, blueberry, mandarin melonberry, mulberry, chokeberry, and Korean black raspberry) based on their metabolite distributions in biosynthetic pathways by non-targeted metabolite profiling and bioactive correlation analysis. Principal component analysis revealed a distinct clustering pattern of metabolites for each berry. Metabolic pathway analysis revealed different biosynthetic routes of secondary metabolites in each berry. Mandarin melonberry contains a relatively higher proportion of genistein, genistein glycoside, and genistein-derived isoflavonoids and prenylflavonoids than the other berries. Various anthocyanin glycosides, synthesized from dihydroquercetin and cyanidin, were more abundant in chokeberry and honeyberry, whereas high levels of flavonoid-and anthocyanins-rutinoside forms were observed in Korean black raspberry. The levels of anthocyanins derived from dihydromyricetin were high in blueberry. The highest anti-oxidant activity was observed in chokeberry and Korean black raspberry, which is positively related to the proportional concentration of flavonoids, phenolics, and anthocyanins. The lowest sugar contents were observed in Korean black raspberry, highest acidity in honeyberry, and lowest acidity in mandarin melonberry, which were specific characteristics among the berries. Taken together, biosynthetic pathway and physicochemical characteristics analyses revealed that the different synthesized routes of flavonoids and anthocyanins and associated bio-activities may be distinct features in each berry and explain their phenotypic diversity at the molecular level

    Lanczos exact diagonalization study of field-induced phase transition for Ising and Heisenberg antiferromagnets

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    Using an exact diagonalization treatment of Ising and Heisenberg model Hamiltonians, we study field-induced phase transition for two-dimensional antiferromagnets. For the system of Ising antiferromagnet the predicted field-induced phase transition is of first order, while for the system of Heisenberg antiferromagnet it is the second-order transition. We find from the exact diagonalization calculations that the second-order phase transition (metamagnetism) occurs through a spin-flop process as an intermediate step.Comment: 4 pages, 4 figure

    Joint Communication, Computation, Caching, and Control in Big Data Multi-access Edge Computing

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    The concept of multi-access edge computing (MEC) has been recently introduced to supplement cloud computing by deploying MEC servers to the network edge so as to reduce the network delay and alleviate the load on cloud data centers. However, compared to a resourceful cloud, an MEC server has limited resources. When each MEC server operates independently, it cannot handle all of the computational and big data demands stemming from the users devices. Consequently, the MEC server cannot provide significant gains in overhead reduction due to data exchange between users devices and remote cloud. Therefore, joint computing, caching, communication, and control (4C) at the edge with MEC server collaboration is strongly needed for big data applications. In order to address these challenges, in this paper, the problem of joint 4C in big data MEC is formulated as an optimization problem whose goal is to maximize the bandwidth saving while minimizing delay, subject to the local computation capability of user devices, computation deadline, and MEC resource constraints. However, the formulated problem is shown to be non-convex. To make this problem convex, a proximal upper bound problem of the original formulated problem that guarantees descent to the original problem is proposed. To solve the proximal upper bound problem, a block successive upper bound minimization (BSUM) method is applied. Simulation results show that the proposed approach increases bandwidth-saving and minimizes delay while satisfying the computation deadlines

    Large displacement vertical translational actuator based on piezoelectric thin films

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    A novel vertical translational microactuator based on thin-film piezoelectric actuation is presented, using a set of four compound bend-up/bend-down unimorphs to produce translational motion of a moving platform or stage. The actuation material is a chemical-solution deposited lead–zirconate–titanate (PZT) thin film. Prototype designs have shown as much as 120 ”m of static displacement, with 80–90 ”m displacements being typical, using four 920 ”m long by 70 ”m legs. Analytical models are presented that accurately describe nonlinear behavior in both static and dynamic operation of prototype stages when the dependence of piezoelectric coefficients on voltage is known. Resonance of the system is observed at a frequency of 200 Hz. The large displacement and high bandwidth of the actuators at low-voltage and low-power levels should make them useful to a variety of optical applications, including endoscopic microscopy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85407/1/jmm10_7_075016.pd
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