14 research outputs found
Brain serotonin 4 receptor binding is inversely associated with verbal memory recall
BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5âHT (4)R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5âHT (4)R binding and affective verbal memory recall. METHODS: Twentyâfour healthy volunteers were scanned with the 5âHT (4)R radioligand [(11)C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Testâ24. The association between 5âHT (4)R binding and affective verbal memory was evaluated using a linear latent variable structural equation model. RESULTS: We observed a significant inverse association across all regions between 5âHT (4)R binding and affective verbal memory performances for positive (p = 5.5 Ă 10(â4)) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5âHT (4)R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance. CONCLUSION: Our findings replicate our previous observation of a negative association between 5âHT (4)R binding and memory performance in an independent cohort and provide novel evidence linking 5âHT (4)R binding, as a biomarker for synaptic 5âHT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
Serotonin transporter gene ( SLC6A4
Abstract Background The short (s) allele of the 5âHTTLPR polymorphism in the promoter region of the human serotonin transporter (5âHTT) gene SLC6A4 has previously been associated with anxietyârelated personality dimensions. However, this relationship has not been confirmed in all studies and may be modified by environmental circumstances and/or psychiatric illness. This study examined whether the temperamental trait sensory processing sensitivity (SPS), characterized by increased responsivity to environmental stimuli, is related to 5âHTTLPR/rs25531 genotype. Methods 5âHTTLPR and rs25531 genotypes, level of SPS, selfâreported Revised NEO Personality Inventory (NEOâPIâR) and Temperament and Character Inventory (TCI) personality profiles, and symptoms of psychological distress (SCLâ90R Global Severity Index) were determined for 405 healthy volunteers. Results Sensory processing sensitivity was highly correlated with the anxietyârelated dimensions of the NEOâPIâR and the TCI models of personality, Neuroticism, and Harm Avoidance, respectively. However, the level of SPS was not associated with the combined 5âHTTLPR and rs25531 sâ˛/sⲠgenotype. Neuroticism and Harm Avoidance were also not associated with 5âHTTLPR/rs25531 sâ˛/sⲠgenotype. Correcting for symptoms of psychological distress had no effect on the relationships between personality and genotype. Conclusion The level of SPS was not associated with serotonin transporter gene variation. Further, combined 5âHTTLPR and rs25531 genotype was not associated with other anxietyârelated dimensions