Modeling and Optimization of Ultrasonic Welding Process for Low Density Polymer: A Review

The purpose of this research is to determine the effect of various weld and machine parameters on ultrasonic weld strength. In this we are going to use thermosetting material named epoxy which is one of the low density polymers. By considering three main parameters that is amplitude, pressure and weld time we are going to conduct the experiment. After doing the welding, we will check the tensile strength of the welded pieces by using UTM. (Universal testing machine).Further with the help of MINITAB software we will optimize the number of experiments

MICROEMULSION BASED NASAL TO BRAIN DELIVERY OF DRUG ACTING ON CNS

Abstract: Background: Fluvoxamine, an antidepressant drug, has absolute bioavailability of only 53% due to high first pass metabolism. Aim: The purpose of this study was to develop and optimize mucoadhesive microemulsion containing Fluvoxamine for intranasal delivery. Materials and Methods: Based on solubility study, Acrysol K150, Tween 20 and polyethylene glycol (PEG) 400 were selected as oil, surfactant and co surfactant respectively. Microemulsions were prepared using water titration method. 2:1% w/w ratio (Tween 20:PEG 400) was selected for formulation development. The prepared microemulsions were optimized for globule size, zeta potential, pH, Viscosity and polydispersity index. The optimized batch was further characterized for% drug content, pH, viscosity and % drug diffusion. Results and Conclusion: All the parameters showed the suitability of microemulsion of Fluvoxamine for intranasal delivery. Carbapol 934P (0.3 % w/w) was used as a polymer for the preparation of mucoadhesive microemulsion to enhance the retention time in the nasal mucosa. Results of nasal toxicity study using excised sheep nasal mucosa showed comparatively no damage to epithelium and so formulation was considered safe for nasal administration. Fluvoxamine mucoadhesive microemulsion showed the highest percentage of diffusion (98.07 ± 0.710 %) after 24h during ex-vivo drug diffusion study through sheep nasal mucosa, followed by Fluvoxamine microemulsion (93.48 ± 0.674%) and finally by Fluvoxamine solution (70.57 ± 0.612%)