Label Selection Approach to Learning from Crowds

Supervised learning, especially supervised deep learning, requires large amounts of labeled data. One approach to collect large amounts of labeled data is by using a crowdsourcing platform where numerous workers perform the annotation tasks. However, the annotation results often contain label noise, as the annotation skills vary depending on the crowd workers and their ability to complete the task correctly. Learning from Crowds is a framework which directly trains the models using noisy labeled data from crowd workers. In this study, we propose a novel Learning from Crowds model, inspired by SelectiveNet proposed for the selective prediction problem. The proposed method called Label Selection Layer trains a prediction model by automatically determining whether to use a worker's label for training using a selector network. A major advantage of the proposed method is that it can be applied to almost all variants of supervised learning problems by simply adding a selector network and changing the objective function for existing models, without explicitly assuming a model of the noise in crowd annotations. The experimental results show that the performance of the proposed method is almost equivalent to or better than the Crowd Layer, which is one of the state-of-the-art methods for Deep Learning from Crowds, except for the regression problem case.Comment: 15 pages, 1 figur

Psychometric properties of the J apanese version of the S ocial P hobia I nventory

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97457/1/pcn12037.pd

Geology of the Northwestern Part in Nariwa-machi, Okayama Prefecture, Japan

This district is situated in the central part of the Kibi plateau which is considered as an elevated peneplain, and has been studied by a lot of geologists and palaeontologists because of abundant occurrences of animal and plant fossils and its complicated geologic structures. The stratigraphy of the district is summarized as follows: [Original table is skipped. For more details, please refer to the full text.] The Palaeozoic rocks are composed of calcareous and non-calcareous groups. The latter consists of non-fossiliferous sandstone, shale and chert, and is named the Fuka formation. The former can be subdivided into 2 members by the lithofacies; the lower is the schalstein-bearing Nakamura limestone group, while the upper is called the Uji formation mainly composed of shale and schalstein sometimes with limestone nodules. From the evidence of fusulinids the calcareous formations are assigned to the Pennsylvanian-Middle Permian in age. The "Inkstone" group, which forms a basin structure, can be subdivided into two parts by the presence of limestone conglomerate; i. e. the upper is composed of the thick red tuff beds, while the lower of the thick limestone conglomerate and thin red tuff layers. The limestone conglomerate is limited to occur in the vicinities of the huge limestone bodies. Judging from the lithofacies, the "Inkstone" group in this district might be the sediments mainly of pyroclastic materials and deposited in a small narrow basin which was due to the Ohga thrust movement. The Palaeozoic Nakamura limestone group thrusts over the Norian Nariwa group, and both of them are covered unconformably by the "Inkstone" group and later extruded andesite and rhyolite masses successively. Therefore, the Ohga thrust movement might be happened in pre-"Inkstone" time.今村外治教授退官記念特集

Using the mood disorder questionnaire and bipolar spectrum diagnostic scale to detect bipolar disorder and borderline personality disorder among eating disorder patients

BACKGROUND: Screening scales for bipolar disorder including the Mood Disorder Questionnaire (MDQ) and Bipolar Spectrum Diagnostic Scale (BSDS) have been plagued by high false positive rates confounded by presence of borderline personality disorder. This study examined the accuracy of these scales for detecting bipolar disorder among patients referred for eating disorders and explored the possibility of simultaneous assessment of co-morbid borderline personality disorder. METHODS: Participants were 78 consecutive female patients who were referred for evaluation of an eating disorder. All participants completed the mood and eating disorder sections of the SCID-I/P and the borderline personality disorder section of the SCID-II, in addition to the MDQ and BSDS. Predictive validity of the MDQ and BSDS was evaluated by Receiver Operating Characteristic analysis of the Area Under the Curve (AUC). RESULTS: Fifteen (19%) and twelve (15%) patients fulfilled criteria for bipolar II disorder and borderline personality disorder, respectively. The AUCs for bipolar II disorder were 0.78 (MDQ) and 0.78 (BDSD), and the AUCs for borderline personality disorder were 0.75 (MDQ) and 0.79 (BSDS). CONCLUSIONS: Among patients being evaluated for eating disorders, the MDQ and BSDS show promise as screening questionnaires for both bipolar disorder and borderline personality disorder

Using the mood disorder questionnaire and bipolar spectrum diagnostic scale to detect bipolar disorder and borderline personality disorder among eating disorder patients

Abstract Background Screening scales for bipolar disorder including the Mood Disorder Questionnaire (MDQ) and Bipolar Spectrum Diagnostic Scale (BSDS) have been plagued by high false positive rates confounded by presence of borderline personality disorder. This study examined the accuracy of these scales for detecting bipolar disorder among patients referred for eating disorders and explored the possibility of simultaneous assessment of co-morbid borderline personality disorder. Methods Participants were 78 consecutive female patients who were referred for evaluation of an eating disorder. All participants completed the mood and eating disorder sections of the SCID-I/P and the borderline personality disorder section of the SCID-II, in addition to the MDQ and BSDS. Predictive validity of the MDQ and BSDS was evaluated by Receiver Operating Characteristic analysis of the Area Under the Curve (AUC). Results Fifteen (19%) and twelve (15%) patients fulfilled criteria for bipolar II disorder and borderline personality disorder, respectively. The AUCs for bipolar II disorder were 0.78 (MDQ) and 0.78 (BDSD), and the AUCs for borderline personality disorder were 0.75 (MDQ) and 0.79 (BSDS). Conclusions Among patients being evaluated for eating disorders, the MDQ and BSDS show promise as screening questionnaires for both bipolar disorder and borderline personality disorder.http://deepblue.lib.umich.edu/bitstream/2027.42/112636/1/12888_2012_Article_1235.pd

Archaeal Phospholipid Biosynthetic Pathway Reconstructed in Escherichia coli

A part of the biosynthetic pathway of archaeal membrane lipids, comprised of 4 archaeal enzymes, was reconstructed in the cells of Escherichia coli. The genes of the enzymes were cloned from a mesophilic methanogen, Methanosarcina acetivorans, and the activity of each enzyme was confirmed using recombinant proteins. In vitro radioassay showed that the 4 enzymes are sufficient to synthesize an intermediate of archaeal membrane lipid biosynthesis, that is, 2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate, from precursors that can be produced endogenously in E. coli. Introduction of the 4 genes into E. coli resulted in the production of archaeal-type lipids. Detailed liquid chromatography/electron spray ionization-mass spectrometry analyses showed that they are metabolites from the expected intermediate, that is, 2,3-di-O-geranylgeranyl-sn-glycerol and 2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphoglycerol. The metabolic processes, that is, dephosphorylation and glycerol modification, are likely catalyzed by endogenous enzymes of E. coli

Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes

細胞内のウイルスを認識する蛋白質の仕組みを解明 --ウイルスから我々の体を守る影のヒーロー--. 京都大学プレスリリース. 2020-12-04.Cytoplasmic RIG-I-like receptor (RLR) proteins in mammalian cells recognize viral RNA and initiate an antiviral response that results in IFN-β induction. Melanoma differentiation-associated protein 5 (MDA5) forms fibers along viral dsRNA and propagates an antiviral response via a signaling domain, the tandem CARD. The most enigmatic RLR, laboratory of genetics and physiology (LGP2), lacks the signaling domain but functions in viral sensing through cooperation with MDA5. However, it remains unclear how LGP2 coordinates fiber formation and subsequent MDA5 activation. We utilized biochemical and biophysical approaches to observe fiber formation and the conformation of MDA5. LGP2 facilitated MDA5 fiber assembly. LGP2 was incorporated into the fibers with an average inter-molecular distance of 32 nm, suggesting the formation of hetero-oligomers with MDA5. Furthermore, limited protease digestion revealed that LGP2 induces significant conformational changes on MDA5, promoting exposure of its CARDs. Although the fibers were efficiently dissociated by ATP hydrolysis, MDA5 maintained its active conformation to participate in downstream signaling. Our study demonstrated the coordinated actions of LGP2 and MDA5, where LGP2 acts as an MDA5 nucleator and requisite partner in the conversion of MDA5 to an active conformation. We revealed a mechanistic basis for LGP2-mediated regulation of MDA5 antiviral innate immune responses

Impacts of ocean acidification and iron enrichment on photosynthetic ability of diatoms in the Bering Sea as estimated from their rbcL gene expressions

第2回極域科学シンポジウム　共通セッション「海氷圏の生物地球化学」 11月16日（水） 統計数理研究所 3階リフレッシュフロ

Microscopic polyangiitis presented with biopsy-confirmed pleuritis

We describe a case of microscopic polyangiitis manifested as pleuritis confirmed by thoracoscopic biopsy. An 80-year-old man presented with a three-day history of shortness of breath and cough. Chest radiography revealed patchy opacities in the lower fields of the bilateral lung and right-sided pleural effusion. Thoracentesis revealed lymphocytic pleural exudates. Thoracoscopic biopsy specimens were compatible with fibrotic pleuritis. He developed rapidly progressive glomerulonephritis with elevated myeloperoxidase anti-neutrophil cytoplasmic antibody titer in blood and pleural effusion. Although the patient was resistant to two weekly courses of pulse steroid therapy, he was successfully treated with a five-day course of intravenous immunoglobulin