Sneutrino-induced like sign dilepton signal with conserved R-parity

Lepton number violation could be manifest in the sneutrino sector of supersymmetric extensions of the standard model with conserved R-parity. Then sneutrinos decay partly into the ``wrong sign charged lepton'' final state, if kinematically accessible. In sneutrino pair production or associated single sneutrino production, the signal then is a like sign dilepton final state. Under favourable circumstances, such a signal could be visible at the LHC or a next generation linear collider for a relative sneutrino mass-splitting of order ${\cal O}(0.001)$ and sneutrino width of order ${\cal O}$(1 GeV). On the other hand, the like sign dilepton event rate at the TEVATRON is probably too small to be observable.Comment: 19 pages, 14 Figures. Section about LSD at LHC and TEVATRON added. Previous Title "Single sneutrino production and the wrong charged lepton signal

Spin diffusion at finite electric and magnetic fields

Spin transport properties at finite electric and magnetic fields are studied by using the generalized semiclassical Boltzmann equation. It is found that the spin diffusion equation for non-equilibrium spin density and spin currents involves a number of length scales that explicitly depend on the electric and magnetic fields. The set of macroscopic equations can be used to address a broad range of the spin transport problems in magnetic multilayers as well as in semiconductor heterostructure. A specific example of spin injection into semiconductors at arbitrary electric and magnetic fields is illustrated

A Supersymmetric D4 Model for mu-tau Symmetry

We construct a supersymmeterized version of the model presented by Grimus and Lavoura (GL) in [1] which predicts theta_{23} maximal and theta_{13}=0 in the lepton sector. For this purpose, we extend the flavor group, which is D4 x Z2^{(aux)} in the original model, to D4 x Z5. An additional difference is the absence of right-handed neutrinos. Despite these changes the model is the same as the GL model, since theta_{23} maximal and theta_{13}=0 arise through the same mismatch of D4 subgroups, D2 in the charged lepton and Z2 in the neutrino sector. In our setup D4 is solely broken by gauge singlets, the flavons. We show that their vacuum structure, which leads to the prediction of theta_{13} and theta_{23}, is a natural result of the scalar potential. We find that the neutrino mass matrix only allows for inverted hierarchy, if we assume a certain form of spontaneous CP violation. The quantity |m_{ee}|, measured in neutrinoless double beta decay, is nearly equal to the lightest neutrino mass m3. The Majorana phases phi1 and phi2 are restricted to a certain range for m3 < 0.06 eV. We discuss the next-to-leading order corrections which give rise to shifts in the vacuum expectation values of the flavons. These induce deviations from maximal atmospheric mixing and vanishing theta_{13}. It turns out that these deviations are smaller for theta_{23} than for theta_{13}.Comment: 19 pages, 4 figure

On the Low Surface Magnetic Field Structure of Quark Stars

Following some of the recent articles on hole super-conductivity and related phenomena by Hirsch \cite{H1,H2,H3}, a simple model is proposed to explain the observed low surface magnetic field of the expected quark stars. It is argued that the diamagnetic moments of the electrons circulating in the electro-sphere induce a magnetic field, which forces the existing quark star magnetic flux density to become dilute. We have also analysed the instability of normal-superconducting interface due to excess accumulation of magnetic flux lines, assuming an extremely slow growth of superconducting phase through a first order bubble nucleation type transition.Comment: 24 pages REVTEX, one .eps figure, psfig.sty is include

How to Create an Innovation Accelerator

Too many policy failures are fundamentally failures of knowledge. This has become particularly apparent during the recent financial and economic crisis, which is questioning the validity of mainstream scholarly paradigms. We propose to pursue a multi-disciplinary approach and to establish new institutional settings which remove or reduce obstacles impeding efficient knowledge creation. We provided suggestions on (i) how to modernize and improve the academic publication system, and (ii) how to support scientific coordination, communication, and co-creation in large-scale multi-disciplinary projects. Both constitute important elements of what we envision to be a novel ICT infrastructure called "Innovation Accelerator" or "Knowledge Accelerator".Comment: 32 pages, Visioneer White Paper, see http://www.visioneer.ethz.c

Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study

Background: Most patients with juvenile myelomonocytic leukemia (JMML) are curable only with allogeneic hematopoietic cell transplantation (HCT). However, the current standard conditioning regimen, busulfan-cyclophosphamide-melphalan (Bu-Cy-Mel), may be associated with higher risks of morbidity and mortality. ASCT1221 was designed to test whether the potentially less-toxic myeloablative conditioning regimen containing busulfan-fludarabine (Bu-Flu) would be associated with equivalent outcomes. Procedure: Twenty-seven patients were enrolled on ASCT1221 from 2013 to 2015. Pre- and post-HCT (starting Day +30) mutant allele burden was measured in all and pre-HCT therapy was administered according to physician discretion. Results: Fifteen patients were randomized (six to Bu-Cy-Mel and nine to Bu-Flu) after meeting diagnostic criteria for JMML. Pre-HCT low-dose chemotherapy did not appear to reduce pre-HCT disease burden. Two patients, however, received aggressive chemotherapy pre-HCT and achieved low disease-burden state; both are long-term survivors. All four patients with detectable mutant allele burden at Day +30 post-HCT eventually progressed compared to two of nine patients with unmeasurable allele burden (P = 0.04). The 18-month event-free survival of the entire cohort was 47% (95% CI, 21–69%), and was 83% (95% CI, 27–97%) and 22% (95% CI, 03–51%) for Bu-Cy-Mel and Bu-Flu, respectively (P = 0.04). ASCT1221 was terminated early due to concerns that the Bu-Flu arm had inferior outcomes. Conclusions: The regimen of Bu-Flu is inadequate to provide disease control in patients with JMML who present to HCT with large burdens of disease. Advances in molecular testing may allow better characterization of biologic risk, pre-HCT responses to chemotherapy, and post-HCT management

Planar and Poly-Arc Lombardi Drawings

In Lombardi drawings of graphs, edges are represented as circular arcs, and the edges incident on vertices have perfect angular resolution. However, not every graph has a Lombardi drawing, and not every planar graph has a planar Lombardi drawing. We introduce k-Lombardi drawings, in which each edge may be drawn with k circular arcs, noting that every graph has a smooth 2-Lombardi drawing. We show that every planar graph has a smooth planar 3-Lombardi drawing and further investigate topics connecting planarity and Lombardi drawings.Comment: Expanded version of paper appearing in the 19th International Symposium on Graph Drawing (GD 2011). 16 pages, 8 figure

Bringing closure: towards achieving a better understanding of Israel

We wholeheartedly endorse Richard Horton’s timely Comment, in which he addresses the global rise of anti-Semitism particularly evident in Europe and the USA. Horton stresses the need to educate medical students and health-care professionals of the evil and disastrous consequences of ignoring the historical reality of the Holocaust. It will remind the world, 75 years on, that the call Never Again remains highly relevant

Non-Abelian Discrete Flavor Symmetries from T^2/Z_N Orbifolds

In [1] it was shown how the flavor symmetry A4 (or S4) can arise if the three fermion generations are taken to live on the fixed points of a specific 2-dimensional orbifold. The flavor symmetry is a remnant of the 6-dimensional Poincare symmetry, after it is broken down to the 4-dimensional Poincare symmetry through compactification via orbifolding. This raises the question if there are further non-abelian discrete symmetries that can arise in a similar setup. To this end, we generalize the discussion by considering all possible 2-dimensional orbifolds and the flavor symmetries that arise from them. The symmetries we obtain from these orbifolds are, in addition to S4 and A4, the groups D3, D4 and D6 \simeq D3 x Z2 which are all popular groups for flavored model building.Comment: 12 pages, 4 figure

A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses

We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants