ヒトiPS細胞からの長期維持可能な高純度心室筋細胞の特異的誘導方法の開発

京都大学新制・論文博士博士(医科学)乙第13443号論医科博第7号新制||医科||9(附属図書館)京都大学大学院医学研究科医科学専攻(主査)教授 長船 健二, 教授 木村 剛, 教授 湊谷 謙司学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDFA

Formation of an Education Network by the Empire of Japan: The Rapid Growth of Japanese Schools in Manchukuo and China

This article analyzes how Japanese schools multiplied in Manchukuo and China in the 1930’s after Japanese military occupation. It is important to note that these schools were authorized by the Japanese government as equal to those of mainland Japan and its colonies. This means that these schools were connected to the network of the Empire of Japan and expanded it. This network was especially stabilized by the establishment of junior high schools. Furthermore, Japanese elementary schools were even founded in undeveloped land in Manchukuo. However, the schools located in these areas tended to be isolated due to the lack of support by the Japanese government. On the other hand, in addition to Japanese people, Korean people joined this network as “Japanese subjects”. Some Japanese schools had more Korean students than Japanese ones. Hence, Japanese assimilation was enabled. For Japanese people, the area was, as it were, the frontier.第3回 広島大学文書館研究集会「戦前期における大学史・高等教育史の再検証 : 東アジアという視点から」の記

MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury

Acute kidney injury (AKI) is a clinical syndrome where a rapid decrease in kidney function and/or urine output is observed, which may result in the imbalance of water, electrolytes and acid base. It is associated with poor prognosis and prolonged hospitalization. Therefore, an early diagnosis and treatment to avoid the severe AKI stage are important. While several biomarkers, such as urinary L-FABP and NGAL, can be clinically useful, there is still no gold standard for the early detection of AKI and there are limited therapeutic options against AKI. miRNAs are non-coding and single-stranded RNAs that silence their target genes in the post-transcriptional process and are involved in a wide range of biological processes. Recent accumulated evidence has revealed that miRNAs may be potential biomarkers and therapeutic targets for AKI. In this review article, we summarize the current knowledge about miRNAs as promising biomarkers and potential therapeutic targets for AKI, as well as the challenges in their clinical use

Radiocesium contamination of lake sediments and fish following the Fukushima nuclear accident and their partition coefficient

To evaluate the influences of the Fukushima nuclear accident in 2011 on lake sediments and fish and to understand the difference in their contamination levels, data on radiocesium concentrations (137Cs and 134Cs) were analyzed for sediments and 18 fish species (including one freshwater prawn) taken from 15 lakes in northeastern Japan. Temporal trends in radiocesium concentrations (referenced to radioactivity on 15 Mar 2011) were not clear during 2011–2013 except in a few species of fish. There was a decrease among topmouth gudgeon (Pseudorasbora parva), icefish (Salangichthys microdon), and pond smelt (Hypomesus nipponensis) but an increase among channel catfish (Ictalurus punctatus) and kokanee (Oncorhynchus nerka). Significant positive correlations between lake-averaged radiocesium concentrations of sediments and fish were observed for most fish species. The partition coefficients (PCs), defined as fish concentration divided by sediment concentration on a dry weight basis, clustered mostly in the range of 0.3–3 ([Bq/kg-dry]/[Bq/kg-dry]) and were high in large-sized types (e.g., channel catfish, and brown trout [Salmo trutta]) but low in small-sized types (e.g., topmouth gudgeon and icefish). After normalization, the PCs of the respective lakes were analyzed together with lake characteristics related to water exchange and lake dimensions, water quality, and sediments and were found to be high in the lakes with high water retention time and vice versa, suggesting prolonged contact and equilibration between the water and the sediments. Finally, the efficacy and potential problems of using the PCs between sediments and fish are discussed

Exploratory Work on the Spinning Condition of the Structure of Staple-core Twin-spun Yarns

In order to design and develop novel-spun yarns with good functionality, we investigated how to construct a core-sheath structure adapted from a multilayered structure of triplet-spun yarn and/or made from a twin-spun yarn with core-staple fibers using an experimental ring-spinning frame. The results were follows: (1) staple-core twin-spun yarn, a new yarn, could be made by applying the production method of triplet-spun yarn and/or combining the production methods of core-spun yarn and twin-spun yarn into one twisting process; (2) by adopting three rovings made from fibers of differing length and fineness, the resulting triplet-spun yarn had the core-sheath structure within an adequate spinning condition; (3) for the construction of core-sheath structure, it is important that there be a difference between spinning tensions at the center and the two sides of the drafted fiber strands or drafted strand lengths from the front roller nip to the point of yarn formation by controlling the distance of the supply rovings and the yarn's twist factor.ArticleTEXTILE RESEARCH JOURNAL. 80(11):1056-1064 (2010)journal articl

Stable Aqueous Suspension and Self-Assembly of Graphite Nanoplatelets Coated with Various Polyelectrolytes

Exfoliated graphite nanoplatelets (xGnPs) with an average thickness of 1–10 nm present an inexpensive alternative to carbon nanotubes in many applications. In this paper, stable aqueous suspension of xGnP was achieved by noncovalent functionalization of xGnP with polyelectrolytes. The surfactants and polyelectrolytes were compared with respect to their ability to suspend graphite nanoplatelets. The surface charge of the nanoplatelets was characterized with zeta potential measurements, and the bonding strength of the polymer chains to the surface of xGnP was characterized with Raman spectroscopy. This robust method opens up the possibility of using this inexpensive nanomaterial in many applications, including electrochemical devices, and leads to simple processing techniques such as layer-by-layer deposition. Therefore, the formation of xGnP conductive coatings using layer-by-layer deposition was also demonstrated