NMR Spectra of Tropolone Derivatives

NMR spectra of bromotropolones and of 5-substituted tropolones have been measured and the effect of those substituents on the tropolone system are discussed compared with the benzene system

Discrimination of models including doubly charged scalar bosons by using tau lepton decay distributions

The doubly charged scalar boson (H^{\pm\pm}) is introduced in several models of the new physics beyond the standard model. The H^{\pm\pm} has Yukawa interactions with two left-handed charged leptons or two right-handed charged leptons depending on the models. We study kinematical properties of H^{\pm\pm} decay products through tau leptons in order to discriminate the chiral structures of the new Yukawa interaction. The chirality of tau leptons can be measured by the energy distributions of the tau decay products, and thus the chiral structure of the new Yukawa interaction can be traced in the invariant-mass distributions of the H^{\pm\pm} decay products. We perform simulation studies for the typical decay patterns of the H^{\pm\pm} with simple event selections and tau-tagging procedures, and show that the chiral structure of the Yukawa interactions of H^{\pm\pm} can be distinguished by measuring the invariant-mass distributions.Comment: 13 pages, 8 eps files; published in Physics Letter

Strategies To Modulate Heritable Epigenetic Defects in Cellular Machinery: Lessons from Nature

Natural epigenetic processes precisely orchestrate the intricate gene network by expressing and suppressing genes at the right place and time, thereby playing an essential role in maintaining the cellular homeostasis. Environment-mediated alteration of this natural epigenomic pattern causes abnormal cell behavior and shifts the cell from the normal to a diseased state, leading to certain cancers and neurodegenerative disorders. Unlike heritable diseases that are caused by the irreversible mutations in DNA, epigenetic errors can be reversed. Inheritance of epigenetic memory is also a major concern in the clinical translation of the Nobel Prize-winning discovery of induced pluripotent stem cell technology. Consequently, there is an increasing interest in the development of novel epigenetic switch-based therapeutic strategies that could potentially restore the heritable changes in epigenetically inherited disorders. Here we give a comprehensive overview of epigenetic inheritance and suggest the prospects of therapeutic gene modulation using epigenetic-based drugs, in particular histone deacetylase inhibitors. This review suggests that there is a need to develop therapeutic strategies that effectively mimic the natural environment and include the ways to modulate the gene expression at both the genetic and epigenetic levels. The development of tailor-made small molecules that could epigenetically alter DNA in a sequence-specific manner is a promising approach for restoring defects in an altered epigenome and may offer a sustainable solution to some unresolved clinical issues

Solid Phase Synthesis of the Active Center Octapeptide of Candida krusei Cytochrome C Apoprotein

The active center octapeptide of Candida krusei cytochrome C apoprotein, H_2N-Cys-Ala-Glu-Cys-His-Thr-Ile-Glu-OH, was synthesized by the Merrifield method using an automatic peptide synthesizer