Berry curvature induced valley Hall effect in non-encapsulated hBN/Bilayer graphene heterostructure aligned with near-zero twist angle

Valley Hall effect has been observed in asymmetric single-layer and bilayer graphene systems. In single-layer graphene systems, asymmetry is introduced by aligning graphene with hexagonal boron nitride (hBN) with a near-zero twist angle, breaking the sub-lattice symmetry. Although a similar approach has been used in bilayer graphene to break the layer symmetry and thereby observe the valley Hall effect, the bilayer graphene was sandwiched with hBN on both sides in those studies. This study looks at a much simpler, non-encapsulated structure where hBN is present only at the top of graphene. The crystallographic axes of both hBN and bilayer graphene are aligned. A clear signature of the valley Hall effect through non-local resistance measurement ($R_{\rm{NL}}$) was observed. The observed non-local resistance could be manipulated by applying a displacement field across the heterostructure. Furthermore, the electronic band structure and Berry curvature calculations validate the experimental observations

FOLFIRI Is Tolerable after Subtotal Colectomy – A Patient with Familial Adenomatous Polyposis Who Developed Advanced Rectal Cancer

A 40-year-old female with familial adenomatous polyposis (FAP) had a subtotal colectomy at 16 years of age. At 39 years, she had low anterior resection due to advanced rectal carcinoma. Thereafter, we administrated per os uracil and tegafur for 9 months. Metastatic rectal carcinoma was detected in the liver (S8) by computed tomography (CT). 2-[(18)F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) data did not show any other metastasis. This report presents a first case of a patient undergoing subtotal colectomy administered FOLFIRI (CPT-11 180 mg/m2 as a 90-minute infusion on day 1; leucovorin 400 mg/m2 as a 2-hour infusion during CPT-11, immediately followed by 5-FU bolus 400 mg/m2 and 46-hour continuous infusion of 2,400 mg/m2 every 2 weeks). This regimen was administered without grade 3 or 4 of any adverse reaction for 6 months, although there was a possibility that this patient with subtotal colectomy may have the cause for severe diarrhea. Further investigations are needed to assess the safety in clinical trials of FOLFIRI regimen for patients with subtotal colectomy

Investigation of guidance on maintaining visual acuity at combined school from kindergarten to junior high school.: Consideration of relationship between visual acuity and lifestyle

The negative effect of visual acuity for growing children led by widely use of IC device such as mobile phone is concerned today. Heavy use of electronic device such as PC in early age will bring poor visual acuity, and an inconvenience in exercise caused by wearing glasses. In this study, we used wearable devise to search relations between daily lives of children and a decrease in vision in add to a preexisting questionnaire. Compared with the duration of watching TV and reading books of PVA( Poor visual acuity) and NPVA(Non poor visual acuity), PVA students were turned out to be using more time in doing, which supports previous studies. The relevance to visual acuity and sleep was clarified to be significantly shorter in NPVA in terms of nocturnal awakening, and also the average of a sleep and a deep sleep duration were longer in NPVA. No significant difference was observed due to the small parameter. From now on, the further work is needed to examine child's sleep conscientiously, including enriching health guidance for sight maintenance

Measurement of local electric field in microdevices for low-voltage electroporation of adherent cells

In this study, we present the measurement of the local electric field in a microdevice designed for electroporation of adherent cells. The microdevice mainly consists of a coverslip that has a transparent conductive layer and an insulating layer. The insulating layer has small cylindrical holes that focus the field lines to reduce the voltage required for electroporation. We estimated the local electric field at the cells by analyzing the ionic current based on a simple equivalent circuit model and investigated the correlation between the field strength and the efficiency of electroporation. We prepared various designs with matrices of electrodes with diameters ranging from 5 to 10 μm and center-to-center distances between adjacent electrodes ranging from 20 to 75 μm to perform systematic and statistical investigations. Furthermore, we discussed the efficiency of the electrode design in terms of the degree of field focusing, the applicability of optical observations, and the probability of positioning cells on the electrodes

Identification of Vanabin-interacting protein 1 (VIP1) from blood cells of the vanadium-rich ascidian Ascidia sydneiensis same

Several species of ascidians, the so-called tunicates, accumulate extremely high levels of vanadium ions in their blood cells. We previously identified a family of vanadium-binding proteins, named Vanabins, from blood cells and blood plasma of a vanadium-rich ascidian, Ascidia sydneiensis samea. The 3-dimensional structure of Vanabin2, the predominant vanadium-binding protein in blood cells, has been revealed, and the vanadium-binding properties of Vanabin2 have been studied in detail. Here, we used Far Western blotting to identify a novel protein that interacts with Vanabin2 from a blood cell cDNA library. The protein, named Vanabin-interacting protein 1 (VIP1), was localized in the cytoplasm of signet ring cells and giant cells. Using a two-hybrid method, we revealed that VIP1 interacted with Vanabins 1, 2, 3, and 4 but not with Vanabin P. The N-terminal domain of VIP1 was shown to be important for the interaction. Further, Vanabin1 was found to interact with all of the other Vanabins. These results suggest that VIP1 and Vanabin1 act as metal chaperones or target proteins in vanadocytes

Three-dimensional surface models of autopsied human brains constructed from multiple photographs by photogrammetry.

Virtual three-dimensional (3D) surface models of autopsied human brain hemispheres were constructed by integrating multiple two-dimensional (2D) photographs. To avoid gravity-dependent deformity, formalin-fixed hemispheres were placed on non-refractile, transparent acrylic plates, which allowed us to take 2D photographs from various different angles. Photogrammetric calculations using software (ReCap Pro cloud service, Autodesk, San Rafael, CA, USA) allowed us calculate the 3D surface of each brain hemisphere. Virtual brain models could be moved and rotated freely to allow smooth, seamless views from different angles and different magnifications. When viewing rotating 3D models on 2D screens, 3D aspects of the models were enhanced using motion parallax. Comparison of different brains using this method allowed us to identify disease-specific patterns of macroscopic atrophy, that were not apparent in conventional 2D photographs. For example, we observed frontal lobe atrophy in a progressive supranuclear palsy brain, and even more subtle atrophy in the superior temporal gyrus in amyotrophic lateral sclerosis-frontotemporal lobar degeneration. Thus, our method facilities recognition of gyral atrophy. In addition, it provides a much more powerful and suitable way of visualizing the overall appearance of the brain as a three-dimensional structure. Comparison of normal and diseased brains will allow us to associate different macroscopic changes in the brain to clinical manifestations of various diseases

Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses

Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the co-evolutionary process of PLVs and their hosts associates with viral pathogenicity, and therefore, that elucidating the history of virus-host co-evolution is one of the most intriguing topics in the field of virology. To address this, recent studies have focused on the interplay between intrinsic anti-viral proteins, such as tetherin, and viral antagonists. Through an experimental-phylogenetic approach, here we investigate the co-evolutionary interplay between tribe Cercopithecini tetherin and viral antagonists, Nef and Vpu. We reveal that tribe Cercopithecini tetherins are positively selected, possibly triggered by ancient Nef-like factor(s). We reconstruct the ancestral sequence of tribe Cercopithecini tetherin and demonstrate that all Nef proteins are capable of antagonizing ancestral Cercopithecini tetherin. Further, we consider the significance of evolutionary arms race between tribe Cercopithecini and their PLVs