A HIGH-PRESSURE PULSED WATER JET CUTTING SYSTEM BY MEANS OF WATER HAMMER IN A CONVERGENT PIPELINE

ABSTRACT One of the authors has developed a high-pressure fuel injection system using an oil hammer for diesel engines in 1993. In the present study, we applied this novel principle of the fuel injection system to the water-jet cutting system, and a pulsed water jet cutting system by means of water hammer in convergent pipeline caused by strong spool acceleration was developed. The system consisted of a pump having a small size plunger and spool, a convergent pipeline, and automatic injector having a hole-type nozzle with a small orifice. This pump, generating strong compression waves at the convergent pipeline inlet by strong acceleration of spool and plunger, is controlled by the low source oil pressure and electromagnetic valve. The wave propagated in the convergent pipeline is dynamically intensified by water hammering in the pipeline. High pressure is then developed at the nozzle. The injection pressure and injection frequency are fully controllable by the source pressure, and by the valve-opening frequency of the electromagnetic valve (EMPV). A computer simulation demonstrated that an operation and the injection pressure are satisfactory as a water jet cutting system. It is shown that a pressure of 140 MPa is obtained in nozzle inlet by a source pressure of 11.8MPa in experiments. The dimension of the nozzle orifice was determined by visualizing the spray origin using a laser-sheet imaging technique. Stagnation force and its spectrum of water jet on work was measured to evaluate effects of injection period and standoff distance on punching time and area. Practical feasibility of water jet cutting system was demonstrated by cutting/punching tests for soft/no-heating materials or metal plates and by paint removing tests

ペスト対話に見える近世ヨーロッパ（一）（史料翻訳）

Dialogvs medico-chymicus. Ein Gesprech/ Vber den Artzten/ so von der jetzo regierenden Seuche der Pestilentz geschrieben haben/ vnd vber jhren Artzneyen/ Gehalten zwischen einem vornemen/ gelehrten Bürger/ vnd einem Handwercksmanne/ in einer berumbten Stadt Sachsenlandes. Anno: 1607.　の翻

Usability of detecting delivery errors during treatment of prostate VMAT with a gantry-mounted transmission detector

Volumetric‐modulated arc therapy (VMAT) requires highly accurate control of multileaf collimator (MLC) movement, rotation speed of linear accelerator gantry, and monitor units during irradiation. Pretreatment validation and monitoring of these factors during irradiation are necessary for appropriate VMAT treatment. Recently, a gantry mounted transmission detector “Delta4 Discover® (D4D)” was developed to detect errors in delivering doses and dose distribution immediately after treatment. In this study, the performance of D4D was evaluated. Simulation plans, in which the MLC position was displaced by 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm from the clinically used original plans, were created for ten patients who received VMAT treatment for prostate cancer. Dose deviation (DD), distance‐to‐agreement (DTA), and gamma index analysis (GA) for each plan were evaluated by D4D. These results were compared to the results (DD, DTA and GA) measured by Delta4 Phantom + (D4P). We compared the deviations between the planned and measured values of the MLC stop positions A‐side and B‐side in five clinical cases of prostate VMAT during treatment and measured the GA values. For D4D, when the acceptable errors for DD, DTA, and GA were determined to be ≤3%, ≤2 mm, and ≤3%/2 mm, respectively, the minimum detectable errors in the MLC position were 2.0, 1.5, and 1.5 mm based on DD, DTA, and GA respectively. The corresponding minimum detectable MLC position errors were 2.0, 1.0, and 1.5 mm, respectively, for D4P. The deviation between the planned and measured position of MLC stopping point of prostate VMAT during treatment was stable at an average of −0.09 ± 0.05 mm, and all GA values were above 99.86%. In terms of delivering doses and dose distribution of VMAT, error detectability of D4D was comparable to that of D4P. The transmission‐type detector “D4D” is thus suitable for detecting delivery errors during irradiation

Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a–T2bN0M0) Non–Small-Cell Lung Cancer

IntroductionAlthough many reports have shown the safety and efficacy of stereotactic body radiotherapy (SBRT) for T1N0M0 non–small-cell lung cancer (NSCLC), it is rather difficult to treat T2N0M0 NSCLC, especially T2b (>5 cm) tumor, with SBRT. Our hypothesis was that particle therapy might be superior to SBRT in T2 patients. We evaluated the clinical outcome of particle therapy for T2a/bN0M0 NSCLC staged according to the 7th edition of the International Union Against Cancer (UICC) tumor, node, metastasis classification.MethodsFrom April 2003 to December 2009, 70 histologically confirmed patients were treated with proton (n = 43) or carbon-ion (n = 27) therapy according to institutional protocols. Forty-seven patients had a T2a tumor and 23 had a T2b tumor. The total dose and fraction (fr) number were 60 (Gray equivalent) GyE/10 fr in 20 patients, 52.8 GyE/4 fr in 16, 66 GyE/10 fr in 16, 80 GyE/20 fr in 14, and other in four patients, respectively. Toxicities were scored according to the Common Terminology Criteria for Adverse Events, Version 4.0.ResultsThe median follow-up period for living patients was 51 months (range, 24–103). For all 70 patients, the 4-year overall survival, local control, and progression-free survival rates were 58% (T2a, 53%; T2b, 67%), 75% (T2a, 70%; T2b, 84%), and 46% (T2a, 43%; T2b, 52%), respectively, with no significant differences between the two groups. The 4-year regional recurrence rate was 17%. Grade 3 pulmonary toxicity was observed in only two patients.ConclusionParticle therapy is well tolerated and effective for T2a/bN0M0 NSCLC. To further improve treatment outcome, adjuvant chemotherapy seems a reasonable option, whenever possible

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice

Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and the α₂-adrenergic receptor (α₂-AR) agonist medetomidine induces lethal damage. Knocking out the C-type lectin Dectin-2 prevents the lethal damage. In spleen, large amounts of platelet-activating factor (PAF) are detected, and knocking out lysophospholipid acyltransferase 9 (LPLAT9/LPCAT2), which encodes an enzyme that converts inactive lyso-PAF to active PAF, protects mice from the lethal damage. These results reveal a linkage/crosstalk between the nervous and the immune system, possibly inducing lethal levels of PAF

Quantum hydrodynamics

Quantum hydrodynamics in superfluid helium and atomic Bose-Einstein condensates (BECs) has been recently one of the most important topics in low temperature physics. In these systems, a macroscopic wave function appears because of Bose-Einstein condensation, which creates quantized vortices. Turbulence consisting of quantized vortices is called quantum turbulence (QT). The study of quantized vortices and QT has increased in intensity for two reasons. The first is that recent studies of QT are considerably advanced over older studies, which were chiefly limited to thermal counterflow in 4He, which has no analogue with classical traditional turbulence, whereas new studies on QT are focused on a comparison between QT and classical turbulence. The second reason is the realization of atomic BECs in 1995, for which modern optical techniques enable the direct control and visualization of the condensate and can even change the interaction; such direct control is impossible in other quantum condensates like superfluid helium and superconductors. Our group has made many important theoretical and numerical contributions to the field of quantum hydrodynamics of both superfluid helium and atomic BECs. In this article, we review some of the important topics in detail. The topics of quantum hydrodynamics are diverse, so we have not attempted to cover all these topics in this article. We also ensure that the scope of this article does not overlap with our recent review article (arXiv:1004.5458), "Quantized vortices in superfluid helium and atomic Bose--Einstein condensates", and other review articles.Comment: 102 pages, 29 figures, 1 tabl

Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study

Background/Aims There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an adenoma-free colon and also assessed the safety of the procedure and the recurrence rate of missed or residual polyp after CFP by performing follow-up colonoscopy 1 year later. Methods We included patients with up to 5 adenomas removed at initial colonoscopy and analyzed data from a total of 361 patients with 573 adenomas. One-year follow-up colonoscopy was performed in 165 patients, at which 251 lesions were confirmed. Results The one-bite resection rate with CFP was highest for lesions 3 mm or smaller and decreased significantly with increasing lesion size. Post-procedural hemorrhage was observed in 1 of 573 lesions (0.17%). No perforation was noted. The definite recurrence rate was 0.8% (2/251 lesions). The probable recurrence rate, which was defined as recurrence in the same colorectal segment, was 17%. Adenoma-free colon was achieved in 55% of patients at initial resection. Multivariate analysis revealed that achievement of an adenoma-free colon was significantly associated with number of adenomas and years of endoscopic experience. Conclusions CFP using jumbo biopsy forceps was safe and showed a high one-bite resection rate for diminutive lesions of 3 mm or smaller. The low definite recurrence rate confirms the reliability of CFP using jumbo biopsy forceps. Number of adenomas and years of endoscopic experience were key factors in achieving an adenoma-free colon