8 research outputs found
A Clinical Study of Photodynamic Therapy for Superficial Esophageal Carcinoma by YAG-OPO Laser
A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal
carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor
affinity was used as the oncotropic compound. The light source was a pulse wave YAG-OPO
laser with high penetration into the tissue. Irradiation was performed at an energy
density of 60–180 J/cm2 48–72 h after PHE administration. Eight lesions in 6 patients
were treated. All were type 0-II superficial carcinomas. The depth of invasion was EP–MM
for 6 lesions and SM for 2 lesions. A complete response (CR) was achieved in all
patients after one session of PDT. Five adverse events, including anemia and fever, were
reported by 4 patients, but all were WHO grade 2 or lower and transient. PDT using
PHE and YAG-OPO laser was therefore considered effective as a curative therapy for
superficial esophageal carcinoma
Cooperative Clinical Trial of Photodynamic Therapy for Early Gastric Cancer With Photofrin Injection® and YAG-OPO Laser
Background and Objective: Photodynamic therapy (PDT) treats malignant tumors using
photosensitizers and light. We employed a new pulse laser as the excitation light source
for PDT, i.e. an optical parametric oscillator (OPO) system pumped by a Q-switched
Nd:YAG laser, because it provides extremely high peak power
A nested PCR-fluorescence assay for the determination of 23S RRNA gene mutations associated with clarithromycin-resistant Helicobacter pylori and its clinical application
Analysis of pure pancreatic juice proteins by two-dimensional gel electrophoresis in cases of pancreatic cancer
Endoscopic classification of chronic gastritis based on a pilot study by the research society for gastritis
Clinical evaluation of dendritic cells vaccination for advanced cancer patients at fukushima medical university
Dendritic cells (DCs) are powerful antigen-presenting cells (APCs) that have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of a strongly immunosuppressed state in cancer-bearing individuals inhibits DC maturation, which is one of the problems facing anti-cancer DC vaccine therapy. Isolated DCs loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals. In clinical trials of DC vaccination for cancer patients, induction of anti-tumor immune responses and tumor regression has been observed. In this study, eighty-one advanced cancer patients unsuccessfully treated by established treatment in individual cases were selected between January 2002 and May 2007 at Fukushima Medical University. The usefulness of DC therapy was investigated by intradermal injection of peptide pulsed DCs for an overall objective response rate of 28.0%. Furthermore, direct injection of immature DCs into tumor extracted an overall objective response rate of 35.7%, and especially 40.0% for advanced pancreatic cancer by using endoscopic ultrasound-guided fine-needle injection technique as a novel approach. These results indicate that DC-based vaccination could be a promising treatment modality for various cancers, however multiple hurdles must be cleared before the development of an affordable DC-based vaccination can be used worldwide