A Study of Modern Education and Sexual Division of Labour

In modern society, there exists sexual division of labour, which is superficially similar to that of patriarchy. And in modern society, the modern idea of sexual equality, which is assimilation of women to men, itself is also the cause of the existence of sexual division of labour

Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex

熱、炎症などに関与するプロスタグランジン受容体EP3シグナリング複合体の可視化 --緑内障、高眼圧症治療薬の合理的設計に貢献--. 京都大学プレスリリース. 2022-09-15.Prostaglandin receptors have been implicated in a wide range of functions, including inflammation, immune response, reproduction, and cancer. Our group has previously determined the crystal structure of the active-like EP3 bound to its endogenous agonist, prostaglandin E₂. Here, we present the single-particle cryoelectron microscopy (cryo-EM) structure of the human EP3-Gi signaling complex at a resolution of 3.4 Å. The structure reveals the binding mode of Gi to EP3 and the structural changes induced in EP3 by Gi binding. In addition, we compare the structure of the EP3-Gi complex with other subtypes of prostaglandin receptors (EP2 and EP4) bound to Gs that have been previously reported and examine the differences in amino acid composition at the receptor-G protein interface. Mutational analysis reveals that the selectivity of the G protein depends on specific amino acid residues in the second intracellular loop and TM5

The Tokyo Oldest Old Survey on Total Health (TOOTH): A longitudinal cohort study of multidimensional components of health and well-being

<p>Abstract</p> <p>Background</p> <p>With the rapid worldwide increase in the oldest old population, considerable concern has arisen about the social and economic burden of diseases and disability in this age group. Understanding of multidimensional structure of health and its life-course trajectory is an essential prerequisite for effective health care delivery. Therefore, we organized an interdisciplinary research team consisting of geriatricians, dentists, psychologists, sociologists, and epidemiologists to conduct a longitudinal observational study.</p> <p>Methods/Design</p> <p>For the Tokyo Oldest Old Survey on Total Health (TOOTH) study, a random sample of inhabitants of the city of Tokyo, aged 85 years or older, was drawn from the basic city registry. The baseline comprehensive assessment consists of an in-home interview, a self-administered questionnaire, and a medical/dental examination. To perform a wide variety of biomedical measurements, including carotid ultrasonography and a detailed dental examination, participants were invited to our study center at Keio University Hospital. For those who were not able to visit the study center, we provided the option of a home-based examination, in which participants were simultaneously visited by a geriatrician and a dentist. Of 2875 eligible individuals, a total of 1152 people were recruited, of which 542 completed both the in-home interview and the medical/dental examination, with 442 completed the in-home interview only, and another 168 completed self or proxy-administered data collection only. Carotid ultrasonography was completed in 458 subjects, which was 99.6% of the clinic visitors (n = 460). Masticatory assessment using a colour-changeable chewing gum was completed in 421 subjects, a 91.5% of the clinic visitors.</p> <p>Discussion</p> <p>Our results demonstrated the feasibility of a new comprehensive study that incorporated non-invasive measurements of subclinical diseases and a detailed dental examination aiming at community-dwelling individuals aged 85 years or older. The bimodal recruitment strategy is critically important to capture a broad range of health profiles among the oldest old. Results form the TOOTH study will help develop new models of health promotion, which are expected to contribute to an improvement in lifelong health and well-being.</p> <p>Trial Registration</p> <p>This study has been registered in the UMIN-Clinical Trial Registry (CTR), ID: UMIN000001842.</p

死別体験における悲嘆の回復過程に関する要因の分析

スマトラ沖大地震・インド洋津波によって，突然肉親と死別体験をもった２遺族に面接調査を行った．死別による悲嘆から回復する過程に，どのような要因が関連しているのかについて分析した．その結果，この地域が敬虔な仏教徒であったことから，対象となった２遺族は，信仰が悲しみを緩和する要因として働いていた．さらに近隣の人びとの精神的な支援や，新たな生命の誕生は将来への希望につながり，悲嘆から回復する要因の一つとなっていることが明らかとなった．Two families that experienced the sudden death of relatives in the Sumatra earthquake and Indian Ocean tsunami were interviewed, and the kinds of factors in the process of healing that sadness were analysed. As a result, it was discovered that, given the devoutly Buddhist nature of the area, the two families’ faith worked to relieve their sadness. There was also psychological support from neighbours and hope for the future embodied in the birth of children, which were also factors in healing their sadness

アンバランゴタ地区の被災現状

昨年１２月２６日に，インドネシアのスマトラ島北端沖で発生したスマトラ沖大地震によるインド洋津波被害で，スマトラについで津波による被害が多かったスリランカに，被災６ヵ月後の復興状況，感染症発生状況，被災者の健康調査などを目的に被災地の調査に入った．スリランカ東南部地域の被災状況を報告し，看護職としての援助のあり方や，物資援助について考察した．We visited Sri Lanka, which received the most damage after Sumatra six months after the Sumatra Earthquake struck the northern coast of the Indonesian island last year on December 26 and caused a tsunami in the Indian Ocean. We investigated reconstruction efforts, the spread of infection and the health conditions of survivors in the southeast portion of the island country, made reports on the devastated areas and made observations on health care and aid supplies

Poster Session

International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discoverry in Academics 2014 [DATE]: January 23(Thu)-24(Fri),2014, [Place]:Kanazawa Excel Hotel Tpkyu, Kanazawa, Japan, [Organizers]:Kanazawa Association of Tumor Biologists / Cancer Research Institute, Kanazawa Universit

新型コロナウイルス感染症流行下における老年看護学実習の検討： 「地域で暮らす高齢者への看護」を学ぶ学内代替実習プログラム

2020年度の新型コロナウイルス蔓延の影響により、従来、介護老人保健施設・介護老人福祉施設で行っていた看護学実習を学内実習に切り替える必要が生じた。本稿では、地域で暮らす高齢者への看護を学ぶ実習科目「老年看護学実習Ⅱ（4年次前期）」の代替実習について報告する。学内実習では、新型コロナウイルスの蔓延が地域で暮らす高齢者に及ぼす影響に焦点を当て、学生が地域の課題に対して感染対策や健康教育を検討する内容とした。本プログラムの特徴は、問題解決能力を養うための学習教材の選定と、高齢者あるいは、高齢者を取り巻く専門職の行動変容を導く「伝える力」の育成にある。今後は、学生の学びを分析し実習プログラムを評価することが必要と考える