Optimally Computing Compressed Indexing Arrays Based on the Compact Directed Acyclic Word Graph

In this paper, we present the first study of the computational complexity of converting an automata-based text index structure, called the Compact Directed Acyclic Word Graph (CDAWG), of size $e$ for a text $T$ of length $n$ into other text indexing structures for the same text, suitable for highly repetitive texts: the run-length BWT of size $r$, the irreducible PLCP array of size $r$, and the quasi-irreducible LPF array of size $e$, as well as the lex-parse of size $O(r)$ and the LZ77-parse of size $z$, where $r, z \le e$. As main results, we showed that the above structures can be optimally computed from either the CDAWG for $T$ stored in read-only memory or its self-index version of size $e$ without a text in $O(e)$ worst-case time and words of working space. To obtain the above results, we devised techniques for enumerating a particular subset of suffixes in the lexicographic and text orders using the forward and backward search on the CDAWG by extending the results by Belazzougui et al. in 2015.Comment: The short version of this paper will appear in SPIRE 2023, Pisa, Italy, September 26-28, 2023, Lecture Notes in Computer Science, Springe

6U CubeSat for Ultraviolet Time-Domain Astronomy

A wide-field ultraviolet observatory for time-domain astronomy utilizing 6U CubeSat is presented. Ultraviolet waveband is one of the unexplored fields in astronomy. Potential targets are short duration transient sources in UV-band: early-phase emission from gravitational wave sources, supernovae shock-breakouts, tidal disruption events around super massive blackholes, etc. The telescope was designed for covering the large error circle of GW detectors, FoV~100 deg2. Thanks to the high quantum efficiency of “delta-doping” detector, the detection limit achieves 20 mag (AB) for 1800 s exposure in NUV band, which is sufficient to detect UV emission from a binary neutron star merger within 200 Mpc from the earth. The satellite has a high-performance on-board computer for on-orbit analysis to detect transient sources and measure the magnitude and the accurate position of the target. The obtained information is required to be transferred to the ground within 30 min from the detection to start multi-messenger follow-up observations utilizing ground-based observatories and astronomical satellites. In this presentation we show the mission overview and conceptual design of the satellite system

Krafft temperature and enthalpy of solution of N-acyl amino acid surfactants and their racemic modifications: Effect of the counter ion

金沢大学工学部The Krafft temperatures and enthalpies of solution of N-hexadecanoyl alaninate and valinate, and N-tetradecanoyl phenylalaninate were obtained from differential scanning calorimetry. The Krafft temperature of N-acyl amino acid surfactant increased with decreasing size of the counter ion, with some exceptions. The enthalpy of solution was endothermic and increased with decreasing size of the counter ion except for the cases of lithium salt. The results showed that the L-L interaction in the solid state of N-hexadecanoyl amino acid surfactant salt was superior to the D-L interaction for both the alanine and valine systems when the counter ion size increased. However, the D-L interaction was still advantageous for the phenylalanine system with Cs+ as a counter ion. Both Fourier transform infrared spectroscopy studies and theoretical calculations suggested that the difference in magnitudes of the interactions between peptide and counter ion was a dominant factor for the chiral effect

Oxidative Deamination Activity of EGCG

(-)-Epigallocatechin-3-O-gallate (EGCG), the most abundant polyphenol in green tea, mediates the oxidative modification of proteins, generating protein carbonyls. However, the underlying molecular mechanism remains unclear. Here we analyzed the EGCG-derived intermediates generated upon incubation with the human serum albumin (HSA) and established that EGCG selectively oxidized the lysine residues via its oxidative deamination activity. In addition, we characterized the EGCG-oxidized proteins and discovered that the EGCG could be an endogenous source of the electrically-transformed proteins that could be recognized by the natural antibodies. When HSA was incubated with EGCG in the phosphate-buffered saline (pH 7.4) at 37°C, the protein carbonylation was associated with the formation of EGCG-derived products, such as the protein-bound EGCG, oxidized EGCG, and aminated EGCG. The aminated EGCG was also detected in the sera from the mice treated with EGCG in vivo. EGCG selectively oxidized lysine residues at the EGCG-binding domains in HSA to generate an oxidatively deaminated product, aminoadipic semialdehyde. In addition, EGCG treatment results in the increased negative charge of the protein due to the oxidative deamination of the lysine residues. More strikingly, the formation of protein carbonyls by EGCG markedly increased its cross-reactivity with the natural IgM antibodies. These findings suggest that many of the beneficial effects of EGCG may be partly attributed to its oxidative deamination activity, generating the oxidized proteins as a target of natural antibodies

Development and Performance of Kyoto's X-ray Astronomical SOI pixel (SOIPIX) sensor

We have been developing monolithic active pixel sensors, known as Kyoto's X-ray SOIPIXs, based on the CMOS SOI (silicon-on-insulator) technology for next-generation X-ray astronomy satellites. The event trigger output function implemented in each pixel offers microsecond time resolution and enables reduction of the non-X-ray background that dominates the high X-ray energy band above 5--10 keV. A fully depleted SOI with a thick depletion layer and back illumination offers wide band coverage of 0.3--40 keV. Here, we report recent progress in the X-ray SOIPIX development. In this study, we achieved an energy resolution of 300~eV (FWHM) at 6~keV and a read-out noise of 33~e- (rms) in the frame readout mode, which allows us to clearly resolve Mn-K$\alpha$ and K$\beta$. Moreover, we produced a fully depleted layer with a thickness of $500~{\rm \mu m}$. The event-driven readout mode has already been successfully demonstrated.Comment: 7pages, 12figures, SPIE Astronomical Telescopes and Instrumentation 2014, Montreal, Quebec, Canada. appears as Proc. SPIE 9147, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ra

Development and Initial On-orbit Performance of Multi-Functional Attitude Sensor using Image Recognition

This paper describes a multi-functional attitude sensor mounted on the “Innovative Satellite 1st” led by Japan Aerospace Exploration Agency which was launched in January 2019. In order to achieve the high accuracy determination in low cost, we developed a novel attitude sensor utilizing real-time image recognition technology, named “Deep Learning Attitude Sensor (DLAS)”. DLAS has two type of attitude sensors: Star Tracker(STT) and Earth Camera (ECAM). For the low-cost development, we adopted commercial off-the-shelf cameras. DLAS uses real-time image recognition technology and a new attitude determination algorithm. In this paper, we present the missions, methods and system configuration of DLAS and initial results of on-orbit experiment that was conducted after the middle of February 2019, and it is confirmed that attitude determinations using ECAM and STT are performed correctly

The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection

BACKGROUND: Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. METHODS: We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 to 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, and imaging findings were compared between patients with and without PAI. TAK was diagnosed based on the American College of Rheumatology Classification Criteria (1990) or the Japanese Clinical Diagnostic Criteria (2008). PAI was identified using enhanced computed tomography, magnetic resonance imaging, or lung scintigraphy. RESULTS: PAI was detected in 14.6% (n = 24) of total TAK patients. Dyspnea (25.0% vs. 8.6%; p = 0.043), pulmonary arterial hypertension (PAH) (16.7% vs. 0.0%; p < 0.001), ischemic heart disease (IHD) (29% vs. 9.3%; p = 0.018), respiratory infection (25.0% vs. 6.0%; p = 0.009), and nontuberculous mycobacteria (NTM) infection (20.8% vs. 0.8%; p < 0.001) were significantly more frequent, and renal artery stenosis (0% vs. 17%; p = 0.007) was significantly less frequent in TAK patients with PAI than in those without PAI. PAI and biologics were risk factors for NTM. CONCLUSIONS: TAK patients with PAI more frequently have dyspnea, PAH, IHD, and respiratory infection, including NTM, than TAK patients without PAI