A Quantitative Approach to Human Capital Management

AbstractThe objective is to provide a quantitative technique to help managers to make decisions by objectively evaluating their Human Capital Management (HCM) and projecting profit increase generated by HCM. This study approach is divided into two steps. In the first step, this study selects and formulates the factors which represent HCM practices by means of principal component and factor analysis. In the second step, personnel adjusted added (PAV) value is defined as the corporate output. Multiple regression model is constructed to identify the HCM factors which influence PAV. This process establishes the model for objectively judging their success of HCM

Deoxofluorination of Activated Carbon Electrode with Sulfur Tetrafluoride for Electric Double Layer Capacitor

Electric double layer capacitors are energy storage devices with advantages of fast charge-discharge and long life span. Surface modification of activated carbon electrodes is an effective way to improve their performance. For this purpose, deoxofluorination of activated carbon with sulfur tetrafluoride was attempted in this study. Successful introduction of fluorine atom on the surface of activated carbon resulted in the increased capacitance and improved coulombic efficiencies in electrochemical tests for electric double layer capacitors

Analyses of spatial dynamics and photosynthesis in kudzu community by remote sensing (リモートセンシングによるクズ群落の空間動態および光合成の解析)

信州大学(Shinshu university)博士（農学）この博士論文は、次の学術雑誌論文を使用しています。 / 雑草研究 65(3) :95-102(2020); doi:10.3719/weed.65.95 © 2020 日本雑草学会 / 雑草研究 66(3) :133-140(2021); doi:10.3719/weed.66.133 © 2021 日本雑草学会Thesis岩本　啓己. Analyses of spatial dynamics and photosynthesis in kudzu community by remote sensig (リモートセンシングによるクズ群落の空間動態および光合成の解析). 信州大学, 2021, 博士論文. 博士（農学）, 乙第25号, 令和03年09月30日授与.doctoral thesi

歯髄幹細胞からの分泌因子は、顎関節変形性関節症の治療に多面的な効果を示す

Objective: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by progressive cartilage degeneration, abnormal bone remodeling, and chronic pain. In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression. Design: To this end, we performed intravenous administration of serum free conditioned media from human exfoliated deciduous teeth stem cells (SHED-CM) into a mechanical-stress induced murine TMJOA model. Results: SHED-CM administration markedly suppressed temporal muscle inflammation, and improved bone integrity and surface smoothness of the destroyed condylar cartilage. Moreover, SHED-CM treatment decreased the number of IL-1β, iNOS, and MMP-13 expressing chondrocytes, whereas it specifically increased PCNA-positive cells in the multipotent polymorphic cell layer. Notably, the numbers of TdT-mediated dUTP nick end labeling (TUNEL)-positive apoptotic chondrocytes in the SHED-CM treated condyles were significantly lower than in those treated with DMEM, whereas the proteoglycan positive area was restored to a level similar to that of the sham treated group, demonstrating that SHED-CM treatment regenerated the mechanical-stress injured condylar cartilage and subchondral bone. Secretome analysis revealed that SHED-CM contained multiple therapeutic factors that act in osteochondral regeneration. Conclusions: Our data demonstrated that SHED-CM treatment promoted the regeneration and repair of mechanical-stress induced mouse TMJOA. Our observations suggest that SHED-CM has potential to be a potent tissue-regenerating therapeutic agent for patients with severe TMJOA

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the spatial–temporal relationship and mode of interaction in vivo remain elusive. Here we show, by using an intravital imaging technique, that mOB and mOC functions are regulated via direct cell–cell contact between these cell types. The mOBs and mOCs mainly occupy discrete territories in the steady state, although direct cell–cell contact is detected in spatiotemporally limited areas. In addition, a pH-sensing fluorescence probe reveals that mOCs secrete protons for bone resorption when they are not in contact with mOBs, whereas mOCs contacting mOBs are non-resorptive, suggesting that mOBs can inhibit bone resorption by direct contact. Intermittent administration of parathyroid hormone causes bone anabolic effects, which lead to a mixed distribution of mOBs and mOCs, and increase cell–cell contact. This study reveals spatiotemporal intercellular interactions between mOBs and mOCs affecting bone homeostasis in vivo

The Receptor-Like Kinase SOL2 Mediates CLE Signaling in Arabidopsis

Arabidopsis sol2 mutants showed CLV3 peptide resistance. Twenty-six synthetic CLE peptides were examined in the clv1, clv2 and sol2 mutants. sol2 showed different levels of resistance to the various peptides, and the spectrum of peptide resistance was quite similar to that of clv2. SOL2 encoded a receptor-like kinase protein which is identical to CORYNE (CRN). GeneChip analysis revealed that the expression of several genes was altered in the sol2 root tip. Here, we suggest that SOL2, together with CLV2, plays an important role in the regulation of root meristem development through the CLE signaling pathway