Traumatic Neuroma of the Gallbladder : Report of a Case

A case of traumatic neuroma of the gallbladder is reported. Most of traumatic neuromas of the biliary system arise at the cystic duct stump after cholecystectomy. Review of the English literature disclosed only one case of traumatic neuroma of the gallbladder. The reported case had a history of unsuccessful cholecystectomy performed twenty years previously. In our case, in contrast, traumatic neuroma developed without a history of previous operation. Prolonged presence of cholecystoduodenal fistula was suspected as an etiological factor

Multiorgan Involvement of Light Chain Deposition Disease : Report of an Autopsy Case

An autopsy case of light chain deposition disease is reported here. A 60-year-old female with plasmacytosis of the bone marrow was disclosed to have amorphous eosinophilic deposits in the kidneys and lungs. Glomerular deposits in kidneys were reminiscent of diabetic nodular glomerulosclerosis. Immunohistochemistry disclosed that they were composed of κ-light chain. Systemic deposition of κ-light chain may occur and should be kept in mind whenever eosinophilic amorphous substance is found in the background of plasma cell dyscrasias

Bile Duct Carcinoma in Association with a Choledochal Cyst : Report of a Case

A case of bile duct carcinoma associated with a pre-existing type I-A choledochal cyst is reported here. A 38-year-old man who had received a Roux-en-Y hepaticojejunostomy for a cyst of the common bile duct 11 years earlier was revealed to have metastatic carcinoma in the lungs. The primary site of the carcinoma was clinically undetermined, but was found by autopsy to be in the bile duct. Although the relation between these two lesions was unclear, circumstantial evidence suggested that they were related to each other. A persistent chronic inflammatory irritation in this area was considered to be responsible for development of the tumor

Sclerosing Mediastinitis of Pulmonary Hilar Type Report of a Case

A case of sclerosing mediastinitis of pulmonary hilar type is presented. Sclerosing mediastinitis is an unusual postinflammatory sclerotic reaction of the mediastinum which presents challenging diagnostic and therapeutic problems when it involves the major bronchi. The clinical, pathological and etiological aspects of this disease entity are summarized

CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis

<p>Abstract</p> <p>Background</p> <p>Metastasis to regional lymph nodes is a common step in the progression of cancer. Recent evidence suggests that tumor production of CXCR4 promotes lymph node metastasis. Nitric oxide (NO) may also increase metastatic ability in human cancers.</p> <p>Methods</p> <p>Nitrite/nitrate levels and functional CXCR4 expression were assessed in K1 and B-CPAP papillary thyroid carcinoma (PTC) cells after induction and/or inhibition of NO synthesis. CXCR4 expression was also analyzed in primary human PTC. The relationship between nitrotyrosine levels, which are a biomarker for peroxynitrate formation from NO in vivo, CXCR4 expression, and lymph node status was also analyzed.</p> <p>Results</p> <p>Production of nitrite/nitrate and functional CXCR4 expression in both cell lines was increased by treatment with the NO donor DETA NONOate. The NOS inhibitor L-NAME eliminated this increase. Positive CXCR4 immunostaining was observed in 60.7% (34/56) of PTCs. CXCR4 expression was significantly correlated with nitrotyrosine levels and lymph node metastasis in human PTC.</p> <p>Conclusion</p> <p>Our data indicate that NO stimulates CXCR4 expression in vitro. Formation of the NO biomarker nitrotyrosine was also correlated with CXCR4 expression and lymph node metastasis in human PTC. NO may induce lymph node metastasis via CXCR4 induction in papillary thyroid carcinoma.</p

Immunohistologic Analysis of Malignant Lymphoma 1. Accuracy of Histological Diagnosis and Usefulness of Monoclonal Antibodies

In order to test whether B cell or T cell origin of malignant lymphomas can be reliably suspected on histological basis alone, and to know the usefulness of some antibodies to lymphocytic cells which are currently available commercially, we reviewed 30 cases of malignant lymphomas both histologically and immunohistochemically. Hematoxylin- eosin stained sections from those cases were reclassified using Lukes and Collins\u27 classification with minor modification. Then, monoclonal antibodies; LCA, MT-1, and MB-1 have been applied to paraffin sections from same cases. In addition, four cases of plasmacytoma and a case of metastatic carcinoma which resembled malignant lymphoma were studied immunohistochemically. Our results indicate that (1) in most cases, T and B cell origin of lymphoma may be accurately classified by H-E stainecd section although further study with more cases is definitely necessary to reach this conclusion. (2) LCA immunoreactivity seemed to be stronger in lymphomas of T cell system. (3) MT-1 and MB-1 immunoreactivity did not correlate perfectly with LCA positivity. And (4) MT-1 ant MB-1 provide useful tools to dictate markers for T and B cell lymphomas in routinely fixed and paraffin-embedded tissue