43 research outputs found
Intraventricular glioneuronal tumor with disseminated lesions at diagnosis - a case report -
A 55-year-old man presented with a large tumor in his lateral ventricles. Magnetic resonance imaging revealed disseminated lesions in the third and fourth ventricles at the time of diagnosis. The patient underwent a partial removal of the tumor in the lateral ventricles. Histologically, the surgical specimens showed glioneuronal differentiation with ganglion or ganglioid cells, Rosenthal fibers, oligodendroglia-like honeycomb appearances, a spongy pattern, perivascular pseudorosettes, and many hyalinized blood vessels. Papillary structure was not observed. The neuronal component showed a moderately high labeling index of Ki-67/MIB-1. We diagnosed this tumor as atypical intraventricular glioneuronal tumor. The disseminated lesions disappeared after chemoradiation therapy with temozolomide, and the residual tumors in the lateral ventricles remained stable for 3 years after the surgery. We discuss the pathological diagnosis, therapy and clinical course with review of the literatures
Transoral surgery for superficial head and neck cancer: National MultiāCenter Survey in Japan
Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real-world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1ā75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2ā357). Adverse events occurred in 12.7%. Life-threatening complications occurred in 0.5%, but there were no treatment-related deaths. During a median follow-up period of 46.1 months (range 1ā113), the 3-year overall survival rate, relapse-free survival rate, cause-specific survival rate, and larynx-preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment
Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : Technical Note
Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : Technical Note
Intraventricular glioneuronal tumor with disseminated lesions at diagnosis - a case report
Resection of positive tissue on methionineāPET is associated with improved survival in glioblastomas
Abstract Background and purpose The volume of excised tumor in contrastāenhanced areas evaluated via magnetic resonance imaging is known to have a strong influence on the survival of patients with glioblastoma (GBM). In this study, we investigated the effect of tumor resection on the survival of patients with GBM in the 11Cāmethionine (MET) accumulation area using METāpositron emission tomography (METāPET). Methods A total of 26 patients (median age, 69 years; 15 males) who had undergone tumor resection and METāPET before and after surgery, after being newly diagnosed with GBM, were included in the study. METāPET before and after tumor resection were compared. The association between the decrease in the maximum standardized uptake value (SUV) of the tumor divided by the normal cortical mean SUV (%; ĪT/N), the MET extent of resection (METāEOR) from the % reduction in the MET accumulation area (%), and residual MET accumulation area (in cm3; METāresidual tumor volume [RTV]), as well as the survival time of patients with GBM, were evaluated via univariate analysis. Results ĪT/N were positively associated with survival (hazard ratio [HR], 0.98 [95% confidence interval (CI), 0.97ā0.99], pĀ =Ā .02). METāRTV revealed a negative association with survival (HR, 1.02 [95% CI, 1.01ā1.04], pĀ =Ā .04). Additionally, METāEOR showed a strong trend with survival (HR, 0.99 [95% CI, 0.97ā1.01], pĀ =Ā .06). Conclusions Surgical resection of METāaccumulated areas in GBM significantly prolongs the survival of patients with GBM. However, a prospective largeāscale multicenter study is needed to confirm our findings